Percorrer por autor "Costa, Gustavo Barreto"
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- Assessment of the potential toxic of naringenin nanoparticles using ex vivo and in silico modelsPublication . Costa, Gustavo Barreto; Rossi, Bruna Franzon; Oliveira, Byanca P.M.; Santo, Diego Espirito; Leimann, Fernanda Vitória; Vitória Leimann, Fernanda Vitória; Romero, Adriano Lopes; Peron, A. P.; Gonçalves, Odinei HessAbstract Naringenin is a flavonoid known for its anti-inflammatory, antineoplastic, antiatherogenic, and antioxidant properties. However, it has poor technological characteristics and limited bioavailability, which hinder its use in food applications. Nanoencapsulation could address these limitations, but safety concerns regarding nanoengineered bioactives need to be resolved before they can be effectively utilized as food additives. The objective of this study was to evaluate the potential cytotoxic, genotoxic, and mutagenic effects of both free and encapsulated naringenin through in vivo experiments using Allium cepa L. roots, along with pharmacokinetic and molecular docking analyses. The results showed that naringenin nanoparticles did not produce significant changes in the cell division index of meristematic cells in A. cepa roots. Additionally, no significant alterations in the mitotic spindle or chromosomal breaks were observed. Molecular docking studies indicated that naringenin effectively binds to the active site of the catalase enzyme (CAT) in a competitive manner, while it attaches to a site away from the active site of superoxide dismutase (SOD2), demonstrating a non-competitive interaction. ADMET property assessments suggested that naringenin exhibits relatively low toxicity and has favorable molecular characteristics for oral administration. In summary, this study supports the potential of naringenin, particularly in its nanoencapsulated form, as a safe and effective ingredient for functional foods, provided that safety concerns regarding nanoencapsulation are adequately addressed.
- Bridging biodiversity and food systems: A nationwide synthesis of non-conventional food plants (PANCs) in BrazilPublication . Costa, Gustavo Barreto; Lopes, Luiz Henrique Silva; Martins, Karina Pinheiro; Brito, Nathália Letícia Hernandez; Ramos, Jhony Silva; Alessi, Ana Caroline Silvestre Barbosa; Silva, Ana Elisa Melo da; Santos, Thais Aparecida; Ferri, Ornella Monique Pereira; Sousa, Maria João; Heleno, Sandrina A.; Rutledge, Douglas Neil; Cardoso, Flávia Aparecida ReitzContext: The increasing erosion of agrobiodiversity and the growing demand for sustainable food systems have intensified interest in non-conventional food plants (PANCs, a term originally proposed in Brazil) as strategic resources for enhancing food security, biodiversity conservation, and rural livelihoods. In Brazil, PANCs are deeply embedded in socioecological systems and traditional knowledge. However, existing studies remain fragmented, region-specific, and lack integrative analyses at the national scale. Objective: This study aims to provide a nationwide synthesis of PANCs in Brazil, analyzing their distribution, uses, and socioecological roles across five macro-regions, and evaluating their contributions to sustainable food systems. Methods: A structured narrative review was conducted using systematic search principles across Scopus, Web of Science, SciELO, and Google Scholar, covering 2000–2024. Studies were selected using defined criteria, and 145 species were compiled. Analyses combined descriptive statistics with qualitative socioecological interpretation of ecological, cultural, and territorial dynamics. Results and conclusions: Results reveal strong regional heterogeneity. The North and Northeast regions have strong links to traditional knowledge, supporting food security and climate adaptation. Southeast and South reflect revalorization driven by markets and agroecology. Central-West highlights tensions between intensification and conservation. PANCs exhibit multifunctionality, contributing to nutrition, ecosystem services, and livelihoods, but face barriers, including limited knowledge and weak value chains. Significance: This study provides the first nationwide synthesis of non-conventional food plants (PANCs) in Brazil, bridging biodiversity and food systems through an integrated socioecological perspective. It highlights PANCs as strategic leverage points for inclusive, diversified, and climate-resilient food systems. Furthermore, the findings support their integration into public policies, including school feeding programs and institutional procurement initiatives, strengthening their role in promoting food security, rural development, and biodiversity conservation.