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Abstract(s)
Propolis is a beehive product with a very complex chemical composition,
widely used in folk medicine because of its several therapeutic activities.
Its biological properties and chemical composition may vary according
to the geografic location and to the different plant sources. Recently, we
reported the mechanism for extration and propolis sample preparation
(Falca˜o et al, Anal. Bioanal. Chem., 2010, 396: 887-897). After that, we
developed a new study for Portuguese propolis and plant samples found
around the hive, and we present in this study the activity of these samples
against pathogenic protozoa. Two different raw propolis samples
from the northeast and centre of Portugal, both acquired from local beekeepers,
were analysed in the present work. For the plant samples we
collect the buds exudates and surface material present on the leaves,
stems of Populus nigra male and female specimens and Cistus lanadifer.
These samples were screened for in vitro activity against the pathogenic
protozoa Plasmodium falciparum, Leishmania infantum, Trypanosoma
cruzi and Trypanosoma bruci. To assess selectivity of action, cytodoxicity
against MRC-5 fibroblast cells was also evaluated. We present in this
communication interesting results, according to criteria set up by
the WHO Special Programme for Research & Training in Tropical
Diseases.
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Citation
Vale, N.; Falcão, S.; Batista, V.; Freire, C.; Maes, L.; Vilas-Boas, Miguel (2010). Screening of portuguese propolis and its plant sources for inhibitory activity against pathogenic protozoa. Basic & Clinical Pharmacology & Toxicology. ISSN 1742-7843. 107: Supl. 1, p. 631