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Título: Synthesis and evaluation of the antiradicalar activity of polyhydroxy-2-styrylchromones
Autor: Santos, Clementina M.M.
Silva, Artur
Cavaleiro, José
Issue Date: 2000
Editora: Universidade de Aveiro
Citação: Santos, Clementina M.M.; Silva, Artur; Cavaleiro, José (2000) - Synthesis and Evaluation of the Antiradicalar Activity of Polyhydroxy-2-styrylchromones . In XIXth European Colloquium on Heterocyclic Chemistry. Aveiro
Resumo: Recent studies have ascribed the cause of several acute and degenerative diseases, including cell aging and carcinogenesis, to the production of free radicals. As a consequence of this, a large number of investigations have been carried out in order to find new, safe and potent antioxidants and to elucidate the corresponding mechanism of action. The evaluation of antioxidant VS. antiradicalar activity of phenolic compounds, either of natural or synthetic origin, is nowadays an important area of research in the field of food and medicinal sciences. We report here the synthesis of severa I new polyhydroxy-2-styrylchromones 1 starting from 2'-hydroxyacetophenones and cinnamic acid derivatives. The diversity of the substitution pattern, which includes the presence of hydroxyl substituents in 5,7,3' and 4' positions of their skeleton and also a 2,3-double bond was taken into consideration. The evaluation of the antiradicalar efficacy of all synthesised 2-styrylchromones 1 was also carried out by a non-enzymatic method and was performed by the DPPH radical method. 1 The experimental procedures for the synthesis, for the evaluation of the antiradicalar activity and for the structural characterisation of all synthesised compounds will be presented and discussed.
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