Biblioteca Digital do Instituto Politécnico de Bragança   Instituto Politécnico de Bragança

Biblioteca Digital do IPB >
Escola Superior de Tecnologia e Gestão >
Tecnologia Química e Biológica >
DTQB - Artigos em Revistas Indexados ao ISI >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10198/1747

Título: Temperature and solvent effects in the solubility of some pharmaceutical compounds: measurements and modeling
Autor: Mota, Fátima
Carneiro, Aristides
Queimada, António
Pinho, Simão
Macedo, Eugénia A.
Palavras-chave: Drugs
Solubility
Measurement
NRTL-SAC
Reference solvent Approach
Issue Date: 2009
Editora: Elsevier
Citação: Mota, Fátima; Carneiro, Aristides; Queimada, António; Pinho, Simão; Macedo, Eugénia (2009) - Temperature and solvent effects in the solubility of some pharmaceutical compounds: measurements and modeling. European Journal of Pharmaceutical Sciences. ISSN 0928-0987. 37:3-4 p.499-507
Resumo: In this work, pure solvent solubilities of drugs, such as paracetamol, allopurinol, furosemide and budesonide, measured in the temperature range between 298.2–315.2K are presented. The solvents under study were water, ethanol, acetone, ethyl acetate, carbon tetrachloride and n-hexane. Measurements were performed using the shake-flask method for generating the saturated solutions followed by compositional analysis by HPLC. Previous literature values on the solubilities of paracetamol were used to assess the experimental methodology employed in this work. No literature data was found for any of the other drugs studied in this assay. Melting properties of the pure drugs were also determined by differential scanning calorimetry (DSC) to provide a broader knowledge about the solubilization process and also for modeling purposes. The solubility data as a function of temperaturewere used to determine the thermodynamic properties of dissolution like, Gibbs energy, enthalpy and entropy. Theoretical work was essentially focused on the evaluation of theNonrandomTwo-Liquid Segment Activity Coefficient (NRTL-SAC) model, which has been referred as a simple and practical thermodynamic framework for drug solubility estimation. A satisfactory agreement was found between experimental and calculated values: the absolute average deviation was 68% for the correlation in the organic solvents and 38% for the prediction in water, where the best results in prediction could be related to the selected solvents.
URI: http://hdl.handle.net/10198/1747
ISSN: 0928-0987
Versão do Editor: http://www.sciencedirect.com/science/journal/09280987
Appears in Collections:DTQB - Artigos em Revistas Indexados ao ISI

Files in This Item:

File Description SizeFormat
EJPS2009.pdf315,75 kBAdobe PDFView/Open
Restrict Access. You can request a copy!
EJPS2009 - resumo.pdf96,51 kBAdobe PDFView/Open

Statistics
FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpaceOrkut
Formato BibTex mendeley Endnote Logotipo do DeGóis 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 


  © Instituto Politécnico de Bragança - Biblioteca Digital - Feedback - Statistics
  Estamos no RCAAP Governo Português separator Ministério da Educação e Ciência   Fundação para a Ciência e a Tecnologia

Financiado por:

POS_C UE