Utilize este identificador para referenciar este registo: http://hdl.handle.net/10198/14483
Título: Health-promoting effects of thymus herba-barona, Thymus pseudolanuginosus, and thymus caespititius Decoctions
Autor: Afonso, Andrea F.
Pereira, Olívia R.
Neto, Rodrigo
Silva, Artur
Cardoso, Susana M.
Palavras-chave: Thymus
Mass spectrometry
Antimicrobial activity
Data: 2017
Editora: MDPI
Citação: Afonso, Andrea F; Pereira, Olívia R.; Neto, Rodrigo; Silva, Artur; Cardoso, Susana M. (2017) – Health-promoting effects of thymus herba-barona, Thymus pseudolanuginosus, and thymus caespititius decoctions. International Journal of Molecular Sciences. ISSN 1422-0067. 18:9, p. 1-14
Resumo: Thymus herba-barona, Thymus pseudolanuginosus, and Thymus caespititius decoctions were screened for their phenolic constituents, along with their potential antioxidant, anti-inflammatory, and antibacterial activities. The total phenolic compounds in the extracts of the three plants ranged from 236.0 ± 26.6 mgGAE/g (T. caespititus) to 293.0 ± 30.5 mgGAE/g of extract (T. pseudolanuginosus), being particularly rich in caffeic acid derivatives, namely rosmarinic acid and its structural isomers, as well as flavones, such as luteolin-O-glucuronide. The T. pseudolanuginosus extract presented the best DPPH radical scavenging ability (EC50 = 10.9 ± 0.7 µg/mL), a high reducing power (EC50 = 32.2 ± 8.2 µg/mL), and effectively inhibited the oxidation of β-carotene (EC50 = 2.4 ± 0.2 µg/mL). The extracts also showed NO(●) scavenging activity close to that of ascorbic acid, and thus might be useful as anti-inflammatory agents. In addition, they exhibited antibacterial activity against gram-negative and gram-positive bacteria. Staphylococcus aureus strains were the most sensitive bacteria to thyme extracts, with minimum inhibitory concentration and minimum bactericidal concentration values in the range of 0.6-3.5 mg/mL. Overall, this work is an important contribution for the phytochemical characterization and the potential antioxidant, anti-inflammatory, and antimicrobial activities of these three Thymus species, which have been poorly explored.
Peer review: yes
URI: http://hdl.handle.net/10198/14483
DOI: 10.3390/ijms18091879
ISSN: 1422-0067
Aparece nas colecções:CIMO - Artigos em Revistas Indexados à WoS/Scopus

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