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Title: Chiral separation of profen enantiomers by preparative liquid chromatography
Author: Ribeiro, António E.
Graça, Nuno S.
Pais, L.S.
Rodrigues, A.E.
Keywords: Profen enantiomers
Chiral separation
Preparative chromatography
Mobile phase composition
Issue Date: 2008
Citation: Ribeiro, A.E.; Graça, N.S.; Pais, L.S.; Rodrigues, A.E. (2008) - Chiral separation of profen enantiomers by preparative liquid chromatography. In XXI Encontro da Sociedade Portuguesa de Química. Porto.
Abstract: In this work, experimental results obtained for the ketoprofen and flurbiprofen enantiomers systems will be shown, including solubility and adsorption measurements, and pulse and breakthrough experiments. Additionally, simulation results, based on the experimental adsorption isotherms measurements, will be presented to compare the performance of fixed-bed and SMB processes. The experimental and simulation results show two different situations. For the separation of ketoprofen enantiomers, pure ethanol is clearly a better mobile phase than the usual high alkane content mobile phases. On the other hand, for the separation of flurbiprofen enantiomers, a 10%ethanol/90%n-hexane is proposed. The results obtained show that an individual study must be carried out for each enantioseparation system, since different profen drugs can show different behaviours.
Peer review: yes
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Appears in Collections:DTQB - Resumos em Proceedings Não Indexados ao ISI/Scopus

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