Biblioteca Digital do Instituto Politécnico de Bragança   Instituto Politécnico de Bragança

Biblioteca Digital do IPB >
Escola Superior de Tecnologia e Gestão >
Tecnologia Química e Biológica >
DTQB - Resumos em Proceedings Não Indexados ao ISI >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10198/1159

Título: Chiral separation of profen enantiomers by preparative liquid chromatography
Autor: Ribeiro, António E.
Graça, Nuno S.
Pais, L.S.
Rodrigues, A.E.
Palavras-chave: Profen enantiomers
Chiral separation
Preparative chromatography
Mobile phase composition
Issue Date: 2008
Citação: Ribeiro, A.E.; Graça, N.S.; Pais, L.S.; Rodrigues, A.E. (2008) - Chiral separation of profen enantiomers by preparative liquid chromatography. In XXI Encontro da Sociedade Portuguesa de Química. Porto.
Resumo: In this work, experimental results obtained for the ketoprofen and flurbiprofen enantiomers systems will be shown, including solubility and adsorption measurements, and pulse and breakthrough experiments. Additionally, simulation results, based on the experimental adsorption isotherms measurements, will be presented to compare the performance of fixed-bed and SMB processes. The experimental and simulation results show two different situations. For the separation of ketoprofen enantiomers, pure ethanol is clearly a better mobile phase than the usual high alkane content mobile phases. On the other hand, for the separation of flurbiprofen enantiomers, a 10%ethanol/90%n-hexane is proposed. The results obtained show that an individual study must be carried out for each enantioseparation system, since different profen drugs can show different behaviours.
Arbitragem científica: Sim
URI: http://hdl.handle.net/10198/1159
Versão do Editor: http://paginas.fe.up.pt/~xxien/programa.html
Appears in Collections:DTQB - Resumos em Proceedings Não Indexados ao ISI

Files in This Item:

File Description SizeFormat
28. 2008 XXI SPQ CP48.pdf251,62 kBAdobe PDFView/Open

Statistics
FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpaceOrkut
Formato BibTex mendeley Endnote Logotipo do DeGóis 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 


  © Instituto Politécnico de Bragança - Biblioteca Digital - Feedback - Statistics
  Estamos no RCAAP Governo Português separator Ministério da Educação e Ciência   Fundação para a Ciência e a Tecnologia

Financiado por:

POS_C UE