Utilize este identificador para referenciar este registo: http://hdl.handle.net/10198/1159
Título: Chiral separation of profen enantiomers by preparative liquid chromatography
Autor: Ribeiro, António E.
Graça, Nuno S.
Pais, L.S.
Rodrigues, A.E.
Palavras-chave: Profen enantiomers
Chiral separation
Preparative chromatography
Mobile phase composition
Data: 2008
Citação: Ribeiro, A.E.; Graça, N.S.; Pais, L.S.; Rodrigues, A.E. (2008) - Chiral separation of profen enantiomers by preparative liquid chromatography. In XXI Encontro da Sociedade Portuguesa de Química. Porto.
Resumo: In this work, experimental results obtained for the ketoprofen and flurbiprofen enantiomers systems will be shown, including solubility and adsorption measurements, and pulse and breakthrough experiments. Additionally, simulation results, based on the experimental adsorption isotherms measurements, will be presented to compare the performance of fixed-bed and SMB processes. The experimental and simulation results show two different situations. For the separation of ketoprofen enantiomers, pure ethanol is clearly a better mobile phase than the usual high alkane content mobile phases. On the other hand, for the separation of flurbiprofen enantiomers, a 10%ethanol/90%n-hexane is proposed. The results obtained show that an individual study must be carried out for each enantioseparation system, since different profen drugs can show different behaviours.
Peer review: yes
URI: http://hdl.handle.net/10198/1159
Versão do Editor: http://paginas.fe.up.pt/~xxien/programa.html
Aparece nas colecções:DTQB - Resumos em Proceedings Não Indexados ao ISI/Scopus

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