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Title: Chiral separation by SMB chromatography
Author: Pais, L.S.
Loureiro, José M.
Rodrigues, A.E.
Keywords: Simulated moving bed chromatography
Computer simulation and optimization
Chiral separation
Bi-naphthol enantiomers
Chiral epoxide enantiomers
Issue Date: 2000
Publisher: Elsevier
Citation: Pais, L.S.; Loureiro, J.M.; Rodrigues, A.E. (2000) - Chiral separation by SMB chromatography. Separation and Purification Technology. ISSN 1383-5866. 20:1, p.67-77
Abstract: The paper deals with chiral separation by simulated moving bed (SMB) chromatography. A model for the prediction of the cyclic steady-state performance of the SMB, based on the analogy with the true moving bed (TMB), is developed assuming multicomponent adsorption equilibria, axial dispersion flow and the linear driving force approximation to describe the intraparticle mass transfer rate. The simulation package is used to predict the effect of operating variables on the process performance and to define the regions for enantiomers separation. The influence of mass transfer resistance in the separation region is analyzed. A practical tool for choosing the better SMB operating conditions as a function of the feed flow-rate is proposed. The experimental operation of a pilot unit of SMB, Licosep 12-26 (Novasep, France), is carried out for the separation of enantiomers and illustrated with two systems: the bi-naphthol and the chiral epoxide enantiomers. Experimental results and model predictions are compared in terms of process performance and internal concentration profiles.
Peer review: yes
ISSN: 1383-5866
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Appears in Collections:DTQB - Artigos em Revistas Indexados ao ISI/Scopus

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