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Anti-inflammatory potential of mushroom extracts and isolated metabolites

2016Journal article Open access
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dc.contributor.authorTaofiq, Oludemi
dc.contributor.authorMartins, Anabela
dc.contributor.authorBarreiro, M.F.
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2016-10-03T08:39:12Z
dc.date.available2016-10-03T08:39:12Z
dc.date.issued2016
dc.description.abstractBackground: In the recent years natural resources are being in focus due to their great potential to be exploited in the discovery/development of novel bioactive compounds and, among them, mushrooms can be highlighted as alternative sources of anti-inflammatory agents. Scope and approach: The present review reports the anti-inflammatory activity of mushroom extracts and of their bioactive metabolites involved in this bioactive action. Additionally the most common assays used to evaluate mushrooms anti-inflammatory activity were also reviewed, including in vitro studies in cell lines, as well as in animal models in vivo. Key findings and conclusions: The anti-inflammatory compounds identified in mushrooms include polysaccharides, terpenes, phenolic acids, steroids, fatty acids and other metabolites. Among them, polysaccharides, terpenoids and phenolic compounds seem to be the most important contributors to the anti-inflammatory activity of mushrooms as demonstrated by numerous studies. However, clinical trials need to be conducted in order to confirm the effectiveness of some of these mushroom compounds namely, inhibitors of NF-κB pathway and of cyclooxygenase related with the expression of many inflammatory mediators.pt_PT
dc.identifier.citationTaofiq, Oludemi; Martins, Anabela; Barreiro, M.F.; Ferreira, Isabel C.F.R. (2016). Anti-inflammatory potential of mushroom extracts and isolated metabolites. Trends in Food Science & Technology. ISSN 0924-2244. 50, p. 193-210pt_PT
dc.identifier.doi10.1016/j.tifs.2016.02.005pt_PT
dc.identifier.issn0924-2244
dc.identifier.urihttp://hdl.handle.net/10198/13350
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectInflammationpt_PT
dc.subjectNSAIDspt_PT
dc.subjectMushroomspt_PT
dc.subjectBioactive compoundspt_PT
dc.titleAnti-inflammatory potential of mushroom extracts and isolated metabolitespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage210pt_PT
oaire.citation.startPage193pt_PT
oaire.citation.titleTrends in Food Science and Technologypt_PT
oaire.citation.volume50pt_PT
person.familyNameMartins
person.familyNameBarreiro
person.familyNameFerreira
person.givenNameAnabela
person.givenNameFilomena
person.givenNameIsabel C.F.R.
person.identifier144781
person.identifier.ciencia-id7B18-A810-6B93
person.identifier.ciencia-id3418-47D5-5746
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0001-6218-4413
person.identifier.orcid0000-0002-6844-333X
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridG-5488-2013
person.identifier.ridL-9802-2014
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id7203013518
person.identifier.scopus-author-id57188719717
person.identifier.scopus-author-id36868826600
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication383370dd-10e5-40e6-9a15-f2201fe95581
relation.isAuthorOfPublication0391987c-ba90-488b-839a-153447ce1f0f
relation.isAuthorOfPublicationbd0d1537-2e03-41fb-b27a-140af9c35db8
relation.isAuthorOfPublication.latestForDiscovery0391987c-ba90-488b-839a-153447ce1f0f

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