Publication
New perspectives of Juglans regia L. phytochemicals against Candida species
| dc.contributor.author | Martins, Natália | |
| dc.contributor.author | Barros, Lillian | |
| dc.contributor.author | Carvalho, Ana Maria | |
| dc.contributor.author | Silva, Sónia | |
| dc.contributor.author | Henriques, Mariana | |
| dc.contributor.author | Ferreira, Isabel C.F.R. | |
| dc.date.accessioned | 2015-11-12T10:22:25Z | |
| dc.date.available | 2015-11-12T10:22:25Z | |
| dc.date.issued | 2014 | |
| dc.description.abstract | Opportunistic fungal infections have deserved special relevance in the last decades, presenting itself, a serious problem in terms of public health. Despite Candida albicans was considered the main agent responsible for those infections, other non-albicans Candida species have also been described in the last years [1-3]. Most of the species are susceptible to antimicrobial drugs, but recently it has been observed a growing number of microorganisms with drug resistance. Therefore, the discover/use of alternative therapies is crucial [4]. Juglans regia L. (walnut) leaves are commonly used in traditional medicine as antiseptic, antimicrobial and anti-inflammatory [5]; those benefits could be related with its richness in phenolic compounds [6]. In the present work, the antifungal potential of the hydroalcoholic extract prepared from walnut leaves was evaluated against a total of nineteen Candida strains (from the species: C.albicans, C.glabrata, C.parapsilosis and C.tropicalis), using the disc diffusion halo assay. All the tested strains were sensible to the plant extract. The obtained values of the inhibitory zones ranged between 0.9-1.4 cm, being the halo maintained after 48h. The observed antifungal activity is certainly related to the phenolic compounds previously determined in the extract [6]: five phenolic acid derivativescaffeoylquinic and p-coumaroylquinic acid derivatives, two dimers and one trimer of procyanidins, twelve flavonols- quercetin, myricetin and kaempferol derivatives, and five taxifolin O-pentoside isomers; 3-Ocaffeoylquinic acids and quercetin O-pentoside were the main phenolic compounds. Further studies are necessaries in order to elucidate the most active compounds and the specific role of each one. | pt_PT |
| dc.identifier.citation | Martins, Natália; Barros, Lillian; Carvalho, Ana Maria; Silva, Sónia; Henriques, Mariana; Ferreira, Isabel C.F.R. (2014). New perspectives of Juglans regia L. phytochemicals against Candida species. In TEMP2014 - Trends in Environmental Microbiology for Public Health. Lisboa | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10198/12330 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.relation | PEst-OE/AGUI0690/2011 | pt_PT |
| dc.relation | PLANTAS MEDICINAIS A UTILIZAR EM FITOTERAPIA COMO ANTI-FÚNGICOS: EFEITO DE COMPOSTOS FENÓLICOS NO CRESCIMENTO DE ESPÉCIES DE CANDIDA EM SUSPENSÃO E EM BIOFILMES | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
| dc.title | New perspectives of Juglans regia L. phytochemicals against Candida species | pt_PT |
| dc.type | conference object | |
| dspace.entity.type | Publication | |
| oaire.awardTitle | PLANTAS MEDICINAIS A UTILIZAR EM FITOTERAPIA COMO ANTI-FÚNGICOS: EFEITO DE COMPOSTOS FENÓLICOS NO CRESCIMENTO DE ESPÉCIES DE CANDIDA EM SUSPENSÃO E EM BIOFILMES | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F87658%2F2012/PT | |
| oaire.citation.title | TEMP2014 Trends in Environmental Microbiology for Public Health | pt_PT |
| person.familyName | Barros | |
| person.familyName | Carvalho | |
| person.familyName | Ferreira | |
| person.givenName | Lillian | |
| person.givenName | Ana Maria | |
| person.givenName | Isabel C.F.R. | |
| person.identifier | 469085 | |
| person.identifier | ID G-7399-2011 | |
| person.identifier | 144781 | |
| person.identifier.ciencia-id | 9616-35CB-D001 | |
| person.identifier.ciencia-id | D31A-35AF-E2A9 | |
| person.identifier.ciencia-id | 9418-CF95-9919 | |
| person.identifier.orcid | 0000-0002-9050-5189 | |
| person.identifier.orcid | 0000-0001-5508-5935 | |
| person.identifier.orcid | 0000-0003-4910-4882 | |
| person.identifier.rid | J-3600-2013 | |
| person.identifier.rid | E-8500-2013 | |
| person.identifier.scopus-author-id | 35236343600 | |
| person.identifier.scopus-author-id | 20336503900 | |
| person.identifier.scopus-author-id | 36868826600 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | conferenceObject | pt_PT |
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