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Bioactive properties of tabebuia impetiginosa-based phytopreparations and phytoformulations: a comparison between extracts and dietary supplements

2015Journal article Open access
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dc.contributor.authorPires, Tânia C.S.P.
dc.contributor.authorDias, Maria Inês
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorCarvalho, Ana Maria
dc.contributor.authorQueiroz, Maria João R.P.
dc.contributor.authorBarros, Lillian
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorMcPhee, Derek J.
dc.creatorPires T.
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2018-03-01T16:04:41Z
dc.date.accessioned2018-03-02T15:49:26Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2018-03-01T16:04:41Z
dc.date.available2018-03-02T15:49:26Z
dc.date.issued2015
dc.description.abstractTabebuia impetiginosa (Mart. ex DC.) Standl. has been used in traditional medicine for many centuries, being nowadays marketed as dried plant material (inner bark) for infusions, pills, and syrups. The main objective of the present work was to validate its popular use through the bioactivity evaluation of the inner bark (methanolic extract and infusion) and of two different formulations (pills and syrup) also based on the same plant-material. The antioxidant activity was evaluated by in vitro assays testing free radical scavenging activity, reducing power and inhibition of lipid peroxidation in brain homogenates. The cytotoxicity was determined in four human tumor cell lines (MCF-7, NCI-H460, HeLa and HepG2, and also in non-tumor cells (porcine liver primary cells, PLP2)). Furthermore, the sample was chemically characterized regarding free sugars, organic acids, fatty acids, and tocopherols. Syrup and methanolic extract showed the highest antioxidant activity, related to their highest amount of phenolics and flavonoids. Methanolic extract was the only sample showing cytotoxic effects on the tested human tumor cell lines, but none of the samples showed toxicity in PLP2. Glucose and oxalic acid were, respectively, the most abundant sugar and organic acid in the sample. Unsaturated predominated over the saturated fatty acids, due to oleic, linoleic, and linolenic acids expression. α- and γ-Tocopherols were also identified and quantified. Overall, T. impetiginosa might be used in different phytoformulations, taking advantage of its interesting bioactive properties and chemical composition.en_EN
dc.description.sponsorshipThe authors are grateful to Foundation for Science and Technology (FCT, Portugal) for financial support to the research centre CIMO (strategic project PEst-OE/AGR/UI0690/2011), L. Barros researcher contract under “Programa Compromisso com Ciência–2008” and R.C. Calhelha grant (SFRH/BPD/BPD/68344/2010).
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationPires, Tânia C.S.P.; Dias, Maria Inês; Calhelha, Ricardo C.; Carvalho, Ana Maria; Queiroz, Maria João R.P.; Barros, Lillian; Ferreira, Isabel C.F.R.; McPhee, Derek J. (2015). Bioactive properties of tabebuia impetiginosa-based phytopreparations and phytoformulations: A comparison between extracts and dietary supplements. Molecules. ISSN 1420-3049. 20, p. 22863-22871en_EN
dc.identifier.doi10.3390/molecules201219885en_EN
dc.identifier.issn1420-3049
dc.identifier.urihttp://hdl.handle.net/10198/16096
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.relationStrategic Project - UI 690 - 2011-2012
dc.subjectAntioxidantsen_EN
dc.subjectChemical compositionen_EN
dc.subjectCytotoxicityen_EN
dc.subjectMethanolic extract/infusion/dietary supplementsen_EN
dc.subjectTabebuia impetiginosaen_EN
dc.titleBioactive properties of tabebuia impetiginosa-based phytopreparations and phytoformulations: a comparison between extracts and dietary supplementsen_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleStrategic Project - UI 690 - 2011-2012
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FAGR%2FUI0690%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F68344%2F2010/PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamSFRH
person.familyNamePires
person.familyNameDias
person.familyNameCalhelha
person.familyNameCarvalho
person.familyNameBarros
person.familyNameFerreira
person.givenNameTânia C.S.P.
person.givenNameMaria Inês
person.givenNameRicardo C.
person.givenNameAna Maria
person.givenNameLillian
person.givenNameIsabel C.F.R.
person.identifier2118829
person.identifierID G-7399-2011
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person.identifier.ciencia-idD31A-35AF-E2A9
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person.identifier.orcid0000-0002-3954-3833
person.identifier.orcid0000-0001-8744-7814
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0001-5508-5935
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridQ-2842-2018
person.identifier.ridM-8242-2013
person.identifier.ridJ-2172-2014
person.identifier.ridJ-3600-2013
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person.identifier.scopus-author-id57057440000
person.identifier.scopus-author-id54388787000
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
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