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Anti-inflammatory activity of mushrooms extracts, identified phenolic acids and their possible metabolites

2015Conference object Open access
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dc.contributor.authorTaofiq, Oludemi
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorHeleno, Sandrina A.
dc.contributor.authorBarros, Lillian
dc.contributor.authorMartins, Anabela
dc.contributor.authorAbreu, Rui M.V.
dc.contributor.authorQueiroz, Maria João R.P.
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2016-01-19T11:56:01Z
dc.date.available2016-01-19T11:56:01Z
dc.date.issued2015
dc.description.abstractMushrooms are rich sources of many bioactive compounds, such as phenolic acids, that play an important role in the organism, acting as antioxidants, antitumors, antimicrobials, immunomodulators, among others. However, their anti-inflammatory activity has not been deeply studied. In the present study, the ethanolic extracts of fourteen edible mushroom species were firstly characterized in terms of phenolic acids and related compounds by HPLC-PDA, followed by the study of the anti-inflammatory activity of those extracts and corresponding identified compounds, by using LPS (lipopolysaccharide) activated RAW 264.7 macrophages and measuring the inhibition in NO production. Furthermore, methylated and glucuronated derivatives of the identified compounds (p-hydroxybenzoic, p-coumaric and cinnamic acids) were synthesised and evaluated for the same bioactivity to understand the contribution of these compounds for the overall activity of the extracts, and to establish structure-activity relationships. Pleurotus ostreatus, Macrolepiota procera, Boletus impolitus and Agaricus bisporus revealed the strongest anti-inflammatory potential, presenting also the highest concentration in cinnamic acid, which was also the individual compound displaying the highest activity. The derivative compounds of p-coumaric acid revealed the strongest properties, especially the compound CoA-M1 (presenting an ester instead of the carboxylic group), that exhibited a very similar activity to the one showed by dexamethasone, used as anti-inflammatory standard. On the contrary, p-hydroxybenzoic acid derivatives revealed the lowest activity. Overall, the conjugation reactions change the chemical structure of phenolic acids and may increase or decrease their activity; nevertheless, the glucuronated and methylated derivatives of the studied compounds are still displaying anti-inflammatory activity.pt_PT
dc.identifier.citationTaofiq, Oludemi; Calhelha, Ricardo C.; Heleno, Sandrina A.; Barros, Lillian; Martins, Anabela; Abreu, Rui M.V.; Queiroz, Maria João R.P.; Ferreira, Isabel C.F.R. (2015). Anti-inflammatory activity of mushrooms extracts, identified phenolic acids and their possible metabolites. In III Encontro de Jovens Investigadores. Bragançapt_PT
dc.identifier.urihttp://hdl.handle.net/10198/12643
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherInstituto Politécnico de Bragançapt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectEdible mushroomspt_PT
dc.subjectPhenolic acidspt_PT
dc.subjectSynthesised derivativespt_PT
dc.subjectAnti-inflammatorypt_PT
dc.subjectHPLC-PDApt_PT
dc.titleAnti-inflammatory activity of mushrooms extracts, identified phenolic acids and their possible metabolitespt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceBragançapt_PT
oaire.citation.titleIII Encontro de Jovens Investigadores do Instituto Politécnico de Bragançapt_PT
person.familyNameCalhelha
person.familyNameHeleno
person.familyNameBarros
person.familyNameMartins
person.familyNameAbreu
person.familyNameFerreira
person.givenNameRicardo C.
person.givenNameSandrina A.
person.givenNameLillian
person.givenNameAnabela
person.givenNameRui M.V.
person.givenNameIsabel C.F.R.
person.identifier469085
person.identifier144781
person.identifier.ciencia-idF313-E3CE-554E
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person.identifier.ciencia-id0F19-0DE2-12A2
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0001-7224-1098
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0001-6218-4413
person.identifier.orcid0000-0002-7745-8015
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridJ-2172-2014
person.identifier.ridL-5951-2014
person.identifier.ridJ-3600-2013
person.identifier.ridG-5488-2013
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id30067731800
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id7203013518
person.identifier.scopus-author-id7003290613
person.identifier.scopus-author-id36868826600
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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