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Phenolic composition and bioactivity of Lavandula pedunculata (Mill.) Cav. samples fromdifferent geographical origin

2018Journal article Open access
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dc.contributor.authorLopes, Catarina Leonor Afonso do Vale
dc.contributor.authorPereira, Eliana
dc.contributor.authorSoković, Marina
dc.contributor.authorCarvalho, Ana Maria
dc.contributor.authorBarata, Ana Maria
dc.contributor.authorLopes, Violeta R.
dc.contributor.authorRocha, Filomena
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorBarros, Lillian
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2019-03-07T09:48:13Z
dc.date.available2019-03-07T09:48:13Z
dc.date.issued2018
dc.description.abstractThe aim of this study was to characterize the phenolic composition and evaluate the bioactivity of several samples of Lavandula pedunculata (Mill.) Cav, and to compare aqueous and hydroethanolic extracts. Plant materials were obtained by growing some accessions (seed samples) of various wild populations from different regions of Portugal conserved at the Portuguese Genebank in Braga. Phenolic compounds were analised by HPLC-DAD-ESI/MSn, antioxidant potential through in vitro assays (DPPH radical scavenging activity, reducing power and inhibition of lipid peroxidation), cytotoxicity on tumor cells (MCF-7, NCI-H460, HeLa and HepG2) and non-tumor (PLP2) cells, anti-inflammatory activity in rat RAW 264.7 macrophages, by the ability to inhibit NO production and antimicrobial potential by the microdilution method with INT dye (iodonitrotetrazolium chloride). Thirteen compounds were identified, being salvianolic acid B, rosmarinic acid and luteolin-7-O-glucuronide, the main compounds present, with values ranging between 44.3⁻582, 50.9⁻550, and 24.36⁻101.5 mg/g extract, respectively. L. pedunculata aqueous extract revealed a higher antioxidant potential (EC50 values between 14 to 530 μg/mL), which could be related to its higher concentration in phenolic compounds; however, the hydroethanolic extract showed a higher anti-inflammatory (lower EC50 values than 124 μg/mL) potential and antiproliferative capacity (lower GI50 values than 34 μg/mL). Thus, this study highlights the bioactive effects of this species and opens up possibilities of uses in food and pharmaceutical formulations. However, there are potential differences in such properties according to geographical origin of plant material, as in general, the samples from Alentejo presented higher results in all the bioactivities, compared with Trás-os-Montes samples.pt_PT
dc.description.sponsorshipThe authors are grateful to the Foundation for Science and Technology (FCT, Portugal) and FEDER under Program PT2020 for financial support to CIMO (UID/AGR/00690/2013), L. Barros and R. Calhelha contracts. The authors are grateful to FEDER-Interreg España-Portugal programme for financial support through the project 0377_Iberphenol_6_E.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationLopes, Catarina; Pereira, Eliana; Soković, Marina; Carvalho, Ana Maria; Barata, Ana Maria; Lopes, Violeta; Rocha, Filomena; Calhelha, Ricardo C.; Barros, Lillian; Ferreira, Isabel C.F.R. (2018). Phenolic composition and bioactivity of Lavandula pedunculata (Mill.) Cav. samples fromdifferent geographical origin. Molecules. ISSN 1420-3049. 1037, p. 1-19pt_PT
dc.identifier.doi10.3390/molecules23051037pt_PT
dc.identifier.issn1420-3049
dc.identifier.urihttp://hdl.handle.net/10198/19096
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAnti-Inflammatory Agentspt_PT
dc.subjectAntioxidantspt_PT
dc.subjectLavandula pedunculata (Mill.) Cav.pt_PT
dc.subjectLipid Peroxidationpt_PT
dc.subjectPhenolspt_PT
dc.subjectPlant Extractspt_PT
dc.titlePhenolic composition and bioactivity of Lavandula pedunculata (Mill.) Cav. samples fromdifferent geographical originpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FAGR%2F00690%2F2013/PT
oaire.citation.issue5pt_PT
oaire.citation.startPage1037pt_PT
oaire.citation.titleMoleculespt_PT
oaire.citation.volume23pt_PT
oaire.fundingStream5876
person.familyNamePereira
person.familyNameCarvalho
person.familyNameCalhelha
person.familyNameBarros
person.familyNameFerreira
person.givenNameEliana
person.givenNameAna Maria
person.givenNameRicardo C.
person.givenNameLillian
person.givenNameIsabel C.F.R.
person.identifierID G-7399-2011
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person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0003-2854-6745
person.identifier.orcid0000-0001-5508-5935
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridQ-8017-2018
person.identifier.ridJ-2172-2014
person.identifier.ridJ-3600-2013
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id55938912300
person.identifier.scopus-author-id20336503900
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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