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Echinacea purpurea (L.) moench: chemical characterization and bioactivity of its extracts and fractions

2020Journal article Open access
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dc.contributor.authorCoelho, Joana C.M.M.
dc.contributor.authorBarros, Lillian
dc.contributor.authorDias, Maria Inês
dc.contributor.authorFinimundy, Tiane C.
dc.contributor.authorAmaral, Joana S.
dc.contributor.authorAlves, Maria José
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorSantos, Paulo F.
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2021-02-27T17:37:49Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2021-02-27T17:37:49Z
dc.date.issued2020
dc.description.abstractEchinacea purpurea (L.) Moench is widely known for its medicinal properties, being one of the most used medicinal plants for its immunostimulant properties. Nevertheless, there is still scarce information on its cytotoxic activity. Thus, this study aims at evaluating the cytotoxicity and antimicrobial activity of several aqueous and organic extracts of the aerial parts of this plant and chemically characterizing the obtained extracts. The analysis was performed by HPLC–DAD–ESI/MS. Fifteen compounds were identified; of these, seven were phenolic acids and eight were flavonoids. Non-polar compounds were evaluated by GC/MS, with a total of sixty-four compounds identified, and the most abundant groups were the sterols, fatty acids and long-chain hydrocarbons. The highest antimicrobial activity was exhibited by the dichloromethane, ethyl acetate, and acetone extracts. Dichloromethane and n-hexane extracts showed the highest cytotoxic activity. Therefore, they were fractionated, and the obtained fractions were also assessed for their cytotoxicity. Notwithstanding, the cytotoxicity of the extracts was superior to that of the obtained fractions, evidencing a possible synergistic effect of different compounds in the whole extracts.en_EN
dc.description.sponsorshipThe authors are grateful to the Foundation for Science and Technology (FCT, Portugal) for financial support by national funds FCT/MCTES to CIMO (UIDB/00690/2020) and CQ-VR (UID/QUI/00616/2013); national funding by FCT, P.I., through the institutional scientific employment program-contract for L. Barros and R. C. Calhelha contracts. FEDER-Interreg España-Portugal programme for financial support through the project 0377_Iberphenol_6_E.
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationCoelho, Joana; Barros, Lillian; Dias, Maria Inês; Finimundy, Tiane C.; Amaral, Joana S.; Alves, Maria José; Calhelha, Ricardo C.; Santos, P. F.; Ferreira, Isabel C.F.R. (2020). Echinacea purpurea (L.) moench: chemical characterization and bioactivity of its extracts and fractions. Pharmaceuticals. ISSN 1424-8247. 13:6, p. 1-16en_EN
dc.identifier.doi10.3390/ph13060125en_EN
dc.identifier.urihttp://hdl.handle.net/10198/23412
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.subjectAntimicrobial activityen_EN
dc.subjectCytotoxicityen_EN
dc.subjectEchinacea purpurea (L.) Moenchen_EN
dc.subjectPhenolic compoundsen_EN
dc.subjectPolar compoundsen_EN
dc.titleEchinacea purpurea (L.) moench: chemical characterization and bioactivity of its extracts and fractionsen_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FQUI%2F00616%2F2013/PT
oaire.fundingStream5876
person.familyNameBarros
person.familyNameDias
person.familyNameFinimundy
person.familyNameAmaral
person.familyNameAlves
person.familyNameCalhelha
person.familyNameFerreira
person.givenNameLillian
person.givenNameMaria Inês
person.givenNameTiane C.
person.givenNameJoana S.
person.givenNameMaria José
person.givenNameRicardo C.
person.givenNameIsabel C.F.R.
person.identifier469085
person.identifier144781
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person.identifier.ciencia-idF313-E3CE-554E
person.identifier.ciencia-id9418-CF95-9919
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person.identifier.orcid0000-0003-3516-0795
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person.identifier.orcid0000-0001-8506-4393
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridJ-3600-2013
person.identifier.ridM-8242-2013
person.identifier.ridM-6624-2016
person.identifier.ridJ-2172-2014
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id54388787000
person.identifier.scopus-author-id16400584800
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
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