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Pachira aquatica: biological activity and chemical composition of leaves, flowers, and seeds

2025Journal article Open access
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datacite.subject.fosCiências Naturais::Ciências Biológicas
datacite.subject.fosEngenharia e Tecnologia::Engenharia Química
datacite.subject.sdg04:Educação de Qualidade
datacite.subject.sdg15:Proteger a Vida Terrestre
dc.contributor.authorRahal, Isabelle Luiz
dc.contributor.authorDias, Angelica Barbosa
dc.contributor.authorCanonico, Gabriela Catuzo Silva
dc.contributor.authorVieira, Marisa Cássia de Araújo Bento
dc.contributor.authorAyob, Rhaira Fernanda Casalvara
dc.contributor.authorGonçalves, José Eduardo
dc.contributor.authorColauto, Nelson Barros
dc.contributor.authorLinde, Giani Andrea
dc.contributor.authorMandim, Filipa
dc.contributor.authorVaz, Josiana A.
dc.contributor.authorBarros, Lillian
dc.contributor.authorValle, Juliana Silveira do
dc.contributor.authorGazim, Zilda Cristiani
dc.date.accessioned2025-12-18T16:17:49Z
dc.date.available2025-12-18T16:17:49Z
dc.date.issued2025
dc.description.abstractThe chemical composition of Pachira aquatica crude extracts flowers, leaves, and seeds was obtained by UHPLC-ESI/qTOF and GC/MS. The antiproliferative activity was evaluated against the human tumour cell lines AGS (gastric), CaCo-2 (colorectal), MCF-7 (breast), and NCI-H460 (lung). The anti-inflammatory and cellular antioxidant activities were also studied. Flavonoids, phenolic acids, coumarins, and saturated fatty acids were identified in the samples. The concentration of extracts responsible for inhibiting 50% of nitric oxide production ranged from (149 to > 400 µg mL−1). Antiproliferative activity against the tumour cell lines was: AGS (GI50 175 to > 400 µg mL−1), Caco-2 (GI50 215 to > 400 µg mL−1), MCF7 (GI50 232 to > 400 µg mL−1) and NCI-H460 (GI50 208 to > 400 µg mL−1). Cellular antioxidant activity remained between 73% to > 2000%. The selectivity index (SI) ranged from 1.00 to 2.78, indicating low antiproliferative activity.eng
dc.description.sponsorshipThe authors thank Universidade Paranaense, UniCesumar, Foundation for Science and Technology (FCT, Portugal) for financial support to CIMO (UIDB/00690/2020 and UIDP/00690/2020) and SusTEC (LA/P/0007/20201); Ph.D. grant of F. M. (SFRH/BD/146614/2019); national funding by F.C.T. and P.I., through the institutional scientific employment program-contract for L. B. contracts., Coordena\u00E7\u00E3o de Aperfei\u00E7oamento de Pessoal de N\u00EDvel Superior - Brazil (CAPES) -finance code 001-, Conselho Nacional de Desenvolvimento Cient\u00EDfico e Tecnol\u00F3gico (CNPq) - finance code 310105/2021-8, and Funda\u00E7\u00E3o Arauc\u00E1ria for the financial support and fellowships.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRahal, Isabelle Luiz; Dias, Angelica Barbosa; Canonico, Gabriela Catuzo Silva; Vieira, Marisa Cássia de Araújo Bento; Ayob, Rhaira Fernanda Casalvara, Gonçalves, José Eduardo; Colauto, Nelson Barros; Linde, Giani Andrea; Mandim, Filipa; Vaz, Josiana A.; Barros, Lillian; Valle, Juliana Silveira do; Gazim, Zilda Cristiani (2025). Pachira aquatica : biological activity and chemical composition of leaves, flowers, and seeds. Natural Product Research. ISSN 1478-6419. 39:16, p. 4814-4819
dc.identifier.doi10.1080/14786419.2024.2346281pt_PT
dc.identifier.issn1478-6419
dc.identifier.urihttp://hdl.handle.net/10198/35285
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherTaylor and Francis
dc.relationMountain Research Center
dc.relationMountain Research Center
dc.relationIntegrated strategies for the development of a novel functional beverage with sustainable production systems
dc.relationAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAmentoflavonept_PT
dc.subjectCatechinpt_PT
dc.subjectFlavonoidspt_PT
dc.subjectPalmitic acidpt_PT
dc.subjectPhenolic acidspt_PT
dc.titlePachira aquatica: biological activity and chemical composition of leaves, flowers, and seedseng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMountain Research Center
oaire.awardTitleMountain Research Center
oaire.awardTitleIntegrated strategies for the development of a novel functional beverage with sustainable production systems
oaire.awardTitleAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F146614%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0007%2F2020/PT
oaire.citation.endPage4819
oaire.citation.issue16
oaire.citation.startPage4814
oaire.citation.titleJournal of Asian Natural Products Research
oaire.citation.volume39
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameMandim
person.familyNameVaz
person.familyNameBarros
person.givenNameFilipa
person.givenNameJosiana A.
person.givenNameLillian
person.identifier469085
person.identifier.ciencia-idF318-9049-EB99
person.identifier.ciencia-id171B-88BA-64F5
person.identifier.ciencia-id9616-35CB-D001
person.identifier.orcid0000-0002-6494-2326
person.identifier.orcid0000-0002-6989-1169
person.identifier.orcid0000-0002-9050-5189
person.identifier.ridJ-3600-2013
person.identifier.scopus-author-id16305323200
person.identifier.scopus-author-id35236343600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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