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Effects of gamma irradiation on cytotoxicity and phenolic compounds of Thymus vulgaris L. and Mentha x piperita L.

2016Journal article Open access
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dc.contributor.authorPereira, Eliana
dc.contributor.authorPimenta, Andreia I.
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorAntonio, Amilcar L.
dc.contributor.authorCabo Verde, Sandra
dc.contributor.authorBarros, Lillian
dc.contributor.authorSantos-Buelga, Celestino
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2018-01-25T10:00:00Z
dc.date.accessioned2018-01-30T16:39:31Z
dc.date.available2018-01-25T10:00:00Z
dc.date.available2018-01-30T16:39:31Z
dc.date.issued2016
dc.description.abstractThe aim of the present study was to evaluate the effects of gamma irradiation on cytotoxicity and phenolic compounds of Thymus vulgaris L. and Menta × piperita L. (methanolic extracts), used in traditional medicine. Thirteen and fourteen phenolic compounds, including caffeoyl derivatives and flavonoid glycosides, were detected in T. vulgaris and Mentha piperita, respectively, none of which was affected by the irradiation dose used (10 kGy). Furthermore, the irradiation up to 10 kGy did not change the cytotoxic properties of peppermint samples on tumor cell lines (MCF-7, NCI-H460, HeLa and HepG2), whereas thyme samples irradiated at 10 kGy increased their cytotoxicity in the assayed tumor cell lines compared with samples submitted to 2 and 5 kGy. All in all, the dose of 10 kGy was considered as suitable to be applied for the purpose of disinfestation and microbial decontamination of these plants without modifying their phenolic composition and bioactive properties.pt_PT
dc.description.sponsorshipThe authors are grateful to Foundation for Science and Technology (FCT, Portugal) for financial support to CIMO (PEst-OE/AGR/ UI0690/2014), C2TN (RECI/AAG-TEC/0400/2012) R.C. Calhelha (SFRH/BPD/BPD/68344/2010) and L. Barros (SFRH/BPD/107855/ 2015). The authors are also grateful to Ministry of Agriculture, Portugal (Project AROMAP- PRODER/FEADER), for financial support of the work and E. Pereira and Andreia I. Pimenta grants, and to “MaisErvas - Aromáticas e Medicinais” company for providing the samples.
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPereira, Eliana; Pimenta, Andreia I.; Calhelha, Ricardo C.; Antonio, Amilcar L.; Verde, Sandra Cabo; Barros, Lillian; Santos-Buelga, Celestino; Ferreira, Isabel C.F.R. (2016). Effects of gamma irradiation on cytotoxicity and phenolic compounds of Thymus vulgaris L. and Mentha x piperita L.. LWT - Food Science and Technology. ISSN 0023-6438. 71, p. 370-377en_EN
dc.identifier.doi10.1016/j.lwt.2016.04.004pt_PT
dc.identifier.issn0023-6438
dc.identifier.urihttp://hdl.handle.net/10198/15323
dc.language.isoeng
dc.peerreviewedyespt_PT
dc.relationSFRH/BPD/BPD/68344/2010
dc.relationApplication of Ionizing Radiation for a Sustainable Environment
dc.relationProviding industry and consumers with new alternative sources of natural additives from plant origin in the classes of preservatives and colouring agents: extraction, purification, stabilization and product development
dc.subjectAromatic herbsen_EN
dc.subjectCytotoxicityen_EN
dc.subjectFood irradiationen_EN
dc.subjectPhenolic compoundsen_EN
dc.titleEffects of gamma irradiation on cytotoxicity and phenolic compounds of Thymus vulgaris L. and Mentha x piperita L.en_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleApplication of Ionizing Radiation for a Sustainable Environment
oaire.awardTitleProviding industry and consumers with new alternative sources of natural additives from plant origin in the classes of preservatives and colouring agents: extraction, purification, stabilization and product development
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/PEst-OE%2FAGR%2FUI0690%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/RECI%2FAAG-TEC%2F0400%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F107855%2F2015/PT
oaire.fundingStream5876
oaire.fundingStream3599-PPCDT
person.familyNamePereira
person.familyNameCalhelha
person.familyNameAntonio
person.familyNameBarros
person.familyNameFerreira
person.givenNameEliana
person.givenNameRicardo C.
person.givenNameAmilcar L.
person.givenNameLillian
person.givenNameIsabel C.F.R.
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person.identifier.orcid0000-0003-2854-6745
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0001-8271-9964
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridQ-8017-2018
person.identifier.ridJ-2172-2014
person.identifier.ridJ-1960-2014
person.identifier.ridJ-3600-2013
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id55938912300
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id44560921900
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticlept_PT
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