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Effects of Ladder-Climbing Exercise on Mammary Cancer: Data from a Chemically Induced Rat Model

2025Journal article Open access
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datacite.subject.fosCiências Agrárias::Ciências Veterinárias
datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg15:Proteger a Vida Terrestre
dc.contributor.authorSilva, Jessica
dc.contributor.authorAzevedo, Tiago
dc.contributor.authorAires, Inês
dc.contributor.authorMedeiros, Catarina
dc.contributor.authorNeuparth, Maria J.
dc.contributor.authorSeixas, Fernanda
dc.contributor.authorFerreira, Rita
dc.contributor.authorFaustino-Rocha, Ana I.
dc.contributor.authorOliveira, Paula A.
dc.contributor.authorDuarte, José Alberto
dc.date.accessioned2025-05-29T15:34:03Z
dc.date.available2025-05-29T15:34:03Z
dc.date.issued2025
dc.description.abstractBreast cancer remains a significant global health issue, affecting both humans and companion animals, particularly female dogs and cats, where mammary tumors are among the most common cancers. Strategies to minimize the impact of this disease on patients, pet owners, and veterinary medicine are essential. This study analyses the effects of resistance training on the development of chemically induced mammary cancer in female Wistar rats, divided into four groups: sedentary control (CTR), sedentary induced (CTR+N-methyl-N-nitrosourea (MNU)), exercised control (EX), and exercised induced (EX+MNU). The exercise protocol involved ladder climbing three times a week for 18 weeks with the load progressively increasing. At the study’s end, blood and histopathological samples were collected and analyzed. Although tumor onset occurred two weeks earlier and incidence was slightly higher in the exercised group (EX+MNU) compared to the control group (CTR+MNU), the mortality rate was lower, and the malignancy was not as aggressive. No systemic inflammation was observed, as the levels of albumin, C-reactive protein (CRP), and interleukin 6 (IL-6) in the MNU groups remained similar to the controls. Exercise has been shown to promote overall health by increasing physical fitness, boosting immunological function, and improving metabolic health. These findings may offer valuable insights into the potential role of resistance training in managing mammary cancer in companion animals. However, further research is required to assess clinical applicability and to establish safe and effective exercise protocols for veterinary oncology.eng
dc.description.sponsorshipThis work was supported by national funds from the FCT—Portuguese Foundation for Science and Technology, under the projects UIDB/04033/2020 (CITAB, DOI: 10.54499/UIDB/04033/2020), LA/P/0126/2020 (INOV4AGRO, https://doi.org/10.54499/LA/P/0126/2020), UIDB/00772/2020 (CE-CAV, https://doi.org/10.54499/UIDB/00772/2020), LA/P/0059/2020 (AL4AnimalS, https://doi.org/10.54499/LA/P/0059/2020), UIDB/00690/2020 (CIMO; https://doi.org/10.54499/UIDB/00690/2020), and UIDP/00690/2020 (CIMO; https://doi.org/10.54499/UIDP/00690/2020), and the doctoral grants awarded to J.S. (2020.07999.BD; https://doi.org/10.54499/2020.07999.BD) and T.A. (2023.01329.BD; https://doi.org/10.54499/2023.01329.BD).
dc.identifier.citationSilva, Jessica; Azevedo, Tiago; Aires, Inês; Medeiros, Catarina; Neuparth, Maria J.; Seixas, Fernanda; Ferreira, Rita; Faustino-Rocha, Ana I.; Oliveira, Paula A.; Duarte, José Alberto (2025). Effects of Ladder-Climbing Exercise on Mammary Cancer: Data from a Chemically Induced Rat Model. Veterinary Sciences. ISSN 2306-7381. 12:4, p. 1-18
dc.identifier.doi10.3390/vetsci12040303
dc.identifier.issn2306-7381
dc.identifier.urihttp://hdl.handle.net/10198/34512
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relationCentre for the Research and Technology of Agro-Environmental and Biological Sciences
dc.relationInstitute for innovation, capacity building and sustainability of agri-food production
dc.relationVeterinary and Animal Science Research Centre
dc.relationAssociate Laboratory for Animal and Veterinary Sciences
dc.relationMountain Research Center
dc.relationMountain Research Center
dc.relation.ispartofVeterinary Sciences
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectBreast cance
dc.subjectPhysical activity
dc.subjectResistance training
dc.subjectWistar rats
dc.titleEffects of Ladder-Climbing Exercise on Mammary Cancer: Data from a Chemically Induced Rat Modeleng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre for the Research and Technology of Agro-Environmental and Biological Sciences
oaire.awardTitleInstitute for innovation, capacity building and sustainability of agri-food production
oaire.awardTitleVeterinary and Animal Science Research Centre
oaire.awardTitleAssociate Laboratory for Animal and Veterinary Sciences
oaire.awardTitleMountain Research Center
oaire.awardTitleMountain Research Center
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04033%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0126%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00772%2F2020/PT
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oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00690%2F2020/PT
oaire.citation.endPage18
oaire.citation.issue4
oaire.citation.startPage1
oaire.citation.titleVeterinary Sciences
oaire.citation.volume12
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
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