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Valorization of Punica granatum l. leaves extracts as a source of bioactive molecules

2023Journal article Open access
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dc.contributor.authorMarcelino, Sandra Andreia
dc.contributor.authorMandim, Filipa
dc.contributor.authorTaofiq, Oludemi
dc.contributor.authorPires, Tânia C.S.P.
dc.contributor.authorFinimundy, Tiane C.
dc.contributor.authorPrieto Lage, Miguel A.
dc.contributor.authorBarros, Lillian
dc.date.accessioned2023-02-23T16:33:15Z
dc.date.available2023-02-23T16:33:15Z
dc.date.issued2023
dc.description.abstractDue to a lack of innovative valorization strategies, pomegranate processing generates a significant amount of residues with a negative environmental footprint. These by-products are a rich source of bioactive compounds with functional and medicinal benefits. This study reports the valorization of pomegranate leaves as a source of bioactive ingredients using maceration, ultrasound, and microwave-assisted extraction techniques. The phenolic composition of the leaf extracts was analyzed using an HPLC-DAD-ESI/MSn system. The extracts' antioxidant, antimicrobial, cytotoxic, anti-inflammatory, and skin-beneficial properties were determined using validated in vitro methodologies. The results showed that gallic acid, (-)-epicatechin, and granatin B were the most abundant compounds in the three hydroethanolic extracts (between 0.95 and 1.45, 0.7 and 2.4, and 0.133 and 3.0 mg/g, respectively). The leaf extracts revealed broad-spectrum antimicrobial effects against clinical and food pathogens. They also presented antioxidant potential and cytotoxic effects against all tested cancer cell lines. In addition, tyrosinase activity was also verified. The tested concentrations (50-400 mu g/mL) ensured a cellular viability higher than 70% in both keratinocyte and fibroblast skin cell lines. The obtained results indicate that the pomegranate leaves could be used as a low-cost source of value-added functional ingredients for potential nutraceutical and cosmeceutical applications.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMarcelino, Sandra Andreia; Mandim, Filipa; Taofiq, Oludemi; Pires, Tânia C.S.P.; Finimundy, Tiane C.; Prieto Lage, Miguel A.; Barros, Lillian (2023). Valorization of Punica granatum l. leaves extracts as a source of bioactive molecules. Pharmaceuticals. eISSN 1424-8247. 16:3, p. 1-18pt_PT
dc.identifier.doi10.3390/ph16030342
dc.identifier.eissn1424-8247
dc.identifier.urihttp://hdl.handle.net/10198/27156
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPI
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectPunica granatum L.pt_PT
dc.subjectPhytochemical compositionpt_PT
dc.subjectBioactive propertiespt_PT
dc.subjectBiowaste valorizationpt_PT
dc.titleValorization of Punica granatum l. leaves extracts as a source of bioactive moleculespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titlePharmaceuticalspt_PT
person.familyNameMarcelino
person.familyNameMandim
person.familyNamePires
person.familyNameFinimundy
person.familyNamePrieto
person.familyNameBarros
person.givenNameSandra Andreia
person.givenNameFilipa
person.givenNameTânia C.S.P.
person.givenNameTiane C.
person.givenNameMiguel A.
person.givenNameLillian
person.identifier2118829
person.identifier107688
person.identifier469085
person.identifier.ciencia-idF318-9049-EB99
person.identifier.ciencia-id321E-2D96-00CA
person.identifier.ciencia-id2F18-67B1-776A
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person.identifier.ciencia-id9616-35CB-D001
person.identifier.orcid0000-0003-1490-9445
person.identifier.orcid0000-0002-6494-2326
person.identifier.orcid0000-0002-3954-3833
person.identifier.orcid0000-0003-3516-0795
person.identifier.orcid0000-0002-3513-0054
person.identifier.orcid0000-0002-9050-5189
person.identifier.ridQ-2842-2018
person.identifier.ridG-4516-2011
person.identifier.ridJ-3600-2013
person.identifier.scopus-author-id57057440000
person.identifier.scopus-author-id35937495700
person.identifier.scopus-author-id35236343600
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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