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Flower extracts of Filipendula ulmaria (L.) Maxim inhibit the proliferation of the NCI-H460 tumour cell line

2014Journal article Open access
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dc.contributor.authorLima, M. João
dc.contributor.authorSousa, Diana
dc.contributor.authorLima, Raquel T.
dc.contributor.authorCarvalho, Ana Maria
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorVasconcelos, M. Helena
dc.date.accessioned2014-08-13T15:40:59Z
dc.date.available2014-08-13T15:40:59Z
dc.date.issued2014
dc.description.abstractFilipendula ulmaria (L.) Maxim (meadowsweet) is a popular medicinal species that can be found throughout most Europe and Asia. The plant is known for its rich antioxidants content, having compounds such as flavonoids and ascorbic acid. Therefore, the aim of this work was to investigate if the flower extracts of F. ulmaria (L.) Maxim have cell growth inhibitory activity in three human tumour cell lines representative of non-small cell lung cancer (NCI-H460), melanoma (A375-C5) and breast adenocarcinoma (MCF-7). One of the most potent extracts was selected to be further studied in the NCI-H460 cells, by investigating its antiproliferative potential, the effect on cell cycle profile and on programmed cell death. The obtained results showed that all the extracts inhibited the growth of the mentioned cell lines, with the one obtained by decoction being the most potent. Its effect on the NCI-H460 cells was due to a reduction in cellular proliferation, but not to alterations in programmed cell death. Interestingly, cellular treatment with the extract caused a statistically significant increase in the cellular levels of p21. Data obtained highlight the potential interest of F. ulmaria as a source of bioactive compounds.por
dc.description.sponsorshipFCT for the grant of R.T.L. (SFRH/BPD/68787/2010) and QREN for the grant of D.S. (NORTE-07-0124-FEDER-000023). IPATIMUP is an Associate Laboratory of the Portuguese Ministry of Science, Technology and Higher Education and is partially supported by FCT.por
dc.identifier.citationLima, M. João; Sousa, Diana; Lima, Raquel T.; Carvalho, Ana Maria; Ferreira, Isabel C.F.R.; Vasconcelos, M. Helena (2014). Flower extracts of Filipendula ulmaria (L.) Maxim inhibit the proliferation of the NCI-H460 tumour cell line. Industrial Crops and Products. ISSN 0926-6690. 59, p. 149–153por
dc.identifier.doi10.1016/j.indcrop.2014.05.009
dc.identifier.issn0926-6690
dc.identifier.urihttp://hdl.handle.net/10198/10149
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevierpor
dc.relationNORTE-07-0124-FEDER-000023
dc.relationSMALL MOLECULES AS APOPTOSIS INDUCERS IN CANCER CELLS: INVESTIGATION OF THE MECHANISM OF ACTION
dc.subjectFilipendula ulmaria (L.) Maximpor
dc.subjectMeadowsweetpor
dc.subjectTumour cell proliferationpor
dc.subjectp21por
dc.titleFlower extracts of Filipendula ulmaria (L.) Maxim inhibit the proliferation of the NCI-H460 tumour cell linepor
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleSMALL MOLECULES AS APOPTOSIS INDUCERS IN CANCER CELLS: INVESTIGATION OF THE MECHANISM OF ACTION
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F68787%2F2010/PT
oaire.citation.endPage153por
oaire.citation.startPage149por
oaire.citation.titleIndustrial Crops and Productspor
oaire.citation.volume59por
person.familyNameCarvalho
person.familyNameFerreira
person.givenNameAna Maria
person.givenNameIsabel C.F.R.
person.identifierID G-7399-2011
person.identifier144781
person.identifier.ciencia-idD31A-35AF-E2A9
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0001-5508-5935
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id20336503900
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication977f5254-f7c5-4c91-873f-2700ecd4692f
relation.isAuthorOfPublicationbd0d1537-2e03-41fb-b27a-140af9c35db8
relation.isAuthorOfPublication.latestForDiscovery977f5254-f7c5-4c91-873f-2700ecd4692f
relation.isProjectOfPublication506940d4-2643-4c8a-a077-9a30b043163a
relation.isProjectOfPublication.latestForDiscovery506940d4-2643-4c8a-a077-9a30b043163a

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