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Medicago spp. as potential sources of bioactive isoflavones: Characterization according to phylogenetic and phenologic factors

2015Journal article Open access
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dc.contributor.authorBarreira, João C.M.
dc.contributor.authorVisnevschi-Necrasov, Tatiana
dc.contributor.authorNunes, Eugénia
dc.contributor.authorCunha, Sara C.
dc.contributor.authorPereira, Graça
dc.contributor.authorOliveira, Beatriz
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2018-03-01T16:05:03Z
dc.date.accessioned2018-03-05T09:18:53Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2018-03-01T16:05:03Z
dc.date.available2018-03-05T09:18:53Z
dc.date.issued2015
dc.description.abstractA high variety of plant species are often proposed as potential natural sources of specific bioactive components, with emphasis in phenolic compounds. However, the ability to produce a determined phytochemical might be variable, even among species with close phylogeny. Furthermore, the metabolic dynamics vary greatly according to phenologic factors. Herein, it was verified whether isoflavone production in Medicago spp. is more associated with phylogenetic or phenologic determinants, to define the optimal productive conditions. Isoflavone profiles were characterized in field-grown Medicago species in three phenologic stages. Isoflavones were extracted by matrix solid-phase dispersion method and analyzed using high-performance liquid chromatography coupled with a diode-array detector. The obtained data were evaluated by a generalized linear model (GLM) and linear discriminant analysis (LDA). Formononetin, genistein and irilone were the most abundant isoflavones, reaching values higher than those present in acknowledged plant sources like soy or red clover. Outputs from GLM and LDA indicate that the phylogenetic factors are the most defining criteria. This study promotes Medicago spp. as potential isoflavone sources, particularly because the effects of these compounds are highly dependent on their type and concentration, with potential application as foodstuff, feedstuff, or in the nutraceutical and pharmaceutica l industry.en_EN
dc.description.sponsorshipVisnevschi-Necrasov and João C.M. Barreira are grateful to ‘‘FCT – Fundação para a Ciência e a Tecnologia’’ for their Grants (SFRH/BD/31734/2006 and SFRH/BPD/72802/2010, respectively). S.C. Cunha is grateful to ‘‘POPH-QREN – Tipologia 4.2, Fundo Social Europeu e Fundo Nacional MCTES’’.
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationBarreira, Joao C.M.; Visnevschi-Necrasov, Tatiana; Nunes, Eugenia; Cunha, Sara C.; Pereira, Graca; Oliveira, M. Beatriz P.P. (2015). Medicago spp. as potential sources of bioactive isoflavones: Characterization according to phylogenetic and phenologic factors. Phytochemistry. ISSN 0031-9422. 116, p. 230-238en_EN
dc.identifier.doi10.1016/j.phytochem.2015.04.011en_EN
dc.identifier.issn0031-9422
dc.identifier.urihttp://hdl.handle.net/10198/16131
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.relationBIOACTIVE PROPERTIES & CYTOPROTECTIVE POTENTIAL OF NATURAL EXTRACTS/INDIVIDUAL COMPOUNDS: APPLICATION OF SINGLE CELL GEL ELECTROPHORESIS AND OTHER BIOCHEMICAL, CHEMICAL AND ELECTROCHEMICAL ASSAYS
dc.subjectGLMen_EN
dc.subjectHPLC-DADen_EN
dc.subjectIsoflavonesen_EN
dc.subjectLDAen_EN
dc.subjectMedicagoen_EN
dc.subjectMSPD extractionen_EN
dc.subjectPhenologyen_EN
dc.subjectPhylogenyen_EN
dc.titleMedicago spp. as potential sources of bioactive isoflavones: Characterization according to phylogenetic and phenologic factorsen_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleBIOACTIVE PROPERTIES & CYTOPROTECTIVE POTENTIAL OF NATURAL EXTRACTS/INDIVIDUAL COMPOUNDS: APPLICATION OF SINGLE CELL GEL ELECTROPHORESIS AND OTHER BIOCHEMICAL, CHEMICAL AND ELECTROCHEMICAL ASSAYS
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F31734%2F2006/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F72802%2F2010/PT
oaire.fundingStreamSFRH
person.familyNameBarreira
person.givenNameJoão C.M.
person.identifier.orcid0000-0003-1233-0990
person.identifier.ridD-8269-2013
person.identifier.scopus-author-id54895546900
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
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relation.isAuthorOfPublication.latestForDiscovery4629b12c-39b0-4da8-8b8d-6efba5cf2d81
relation.isProjectOfPublicationd0bf18e1-a4f9-4289-b893-c9efe306d498
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