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Chemotherapeutic properties and side-effects associated with the clinical practice of terpene alkaloids: paclitaxel, docetaxel, and cabazitaxel

2023Journal article Open access
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dc.contributor.authorSousa-Pimenta, Mário
dc.contributor.authorEstevinho, Leticia M.
dc.contributor.authorSzopa, Agnieszka
dc.contributor.authorBasit, Mahnoor
dc.contributor.authorKhan, Khushbukhat
dc.contributor.authorArmaghan, Muhammad
dc.contributor.authorIbrayeva, Manshuk
dc.contributor.authorGurer, Eda Sonmez
dc.contributor.authorCalina, Daniela
dc.contributor.authorHano, Christophe
dc.contributor.authorSharifi-Rad, Javad
dc.date.accessioned2023-07-13T16:10:21Z
dc.date.available2023-07-13T16:10:21Z
dc.date.issued2023
dc.description.abstractOver the years, many biological and synthetic agents have been explored and tested in attempts to halt the spread of cancer and/or cure it. Currently, several natural compounds have and are being considered in this regard. For example, paclitaxel is a potent anticancer drug that originates from the tree Taxus brevifolia. Paclitaxel has several derivatives, namely, docetaxel and cabazitaxel. These agents work by disrupting microtubule assembling dynamics and inducing cell cycle arrest at the G2/M phase of the cell cycle, ultimately triggering apoptosis. Such features have helped to establish paclitaxel as an authoritative therapeutic compound against neoplastic disorders. After the completion of compound (hemi) synthesis, this drug received approval for the treatment of solid tumors either alone or in combination with other agents. In this review, we explore the mechanisms of action of paclitaxel and its derivatives, the different formulations available, as well as the molecular pathways of cancer resistance, potential risks, and other therapeutic applications. In addition, the role of paclitaxel in hematological malignancies is explored, and potential limitations in the therapeutic use of paclitaxel at the clinical level are examined. Furthermore, paclitaxel is known to cause increased antigen presentation. The immunomodulatory potential of taxanes, alone or in combination with other pharmacologic agents, is explored. Despite terpene-alkaloids derivatives' anti-mitotic potential, the impact of this class of drugs on other oncogenic pathways, such as epithelial-to-mesenchymal transition and the epigenetic modulation of the transcription profile of cancer cells, is also analyzed, shedding light on potential future chemotherapeutic approaches to cancer.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSousa-Pimenta, Mário; Estevinho, Leticia M.; Szopa, Agnieszka; Basit, Mahnoor; Khan, Khushbukhat; Armaghan, Muhammad; Ibrayeva, Manshuk; Gurer, Eda Sonmez; Calina, Daniela; Hano, Christophe; Sharifi-Rad, Javad (2023). Chemotherapeutic properties and side-effects associated with the clinical practice of terpene alkaloids: paclitaxel, docetaxel, and cabazitaxel. Frontiers in Pharmacology. eISSN 1663-9812. 14, p. 1-14pt_PT
dc.identifier.doi10.3389/fphar.2023.1157306
dc.identifier.eissn1663-9812
dc.identifier.urihttp://hdl.handle.net/10198/28528
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontierspt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectPaclitaxelpt_PT
dc.subjectDocetaxelpt_PT
dc.subjectCabazitaxelpt_PT
dc.subjectToxoidspt_PT
dc.subjectTaxus brevifoliapt_PT
dc.subjectAnticancer mechanisms
dc.titleChemotherapeutic properties and side-effects associated with the clinical practice of terpene alkaloids: paclitaxel, docetaxel, and cabazitaxelpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleFrontiers in Pharmacologypt_PT
person.familyNameEstevinho
person.givenNameLetícia M.
person.identifier.ciencia-idBA14-09D6-A406
person.identifier.orcid0000-0002-9249-1948
person.identifier.scopus-author-id6506577664
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication4a1d5ba2-1854-4ca5-89a4-73f35e964df9
relation.isAuthorOfPublication.latestForDiscovery4a1d5ba2-1854-4ca5-89a4-73f35e964df9

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