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In vitro blood flow in circular PDMS microchannels: effect of the flow rate and hematocrit

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dc.contributor.authorGarcia, Valdemar
dc.contributor.authorDias, Ricardo P.
dc.contributor.authorCorreia, Teresa Montenegro
dc.contributor.authorLima, Rui A.
dc.contributor.authorPinheiro, Elisa
dc.contributor.authorPinho, Diana
dc.contributor.authorRodrigues, Pedro João
dc.date.accessioned2011-05-30T09:44:51Z
dc.date.available2011-05-30T09:44:51Z
dc.date.issued2010
dc.description.abstractRecently, Lima et al. (1) has performed confocal micro-PIV measurements on the blood flow through straight PDMS microchannel. In the study they have observed that the formation of the cell free layer is enhanced as the cross section ratio increases. However, the cross section ratio is not the only parameter that contributes for the creation of the cell-free layer. Hence, several other physical and hemorheological factors (such as flow rate, hematocrit, viscosity and cell deformability) need to be investigated in order to make use on the physics of microfluidics to either develop new lab-on-chip devices or to optimize the design of the existent microfluidic chips. The main aim of the present study is to show the effect of both flow rate and hematocrit on the blood flow and cell behavior. The circular polydimethylsiloxane (PDMS) microchannels were fabricated by using wire casting technique and the experiments were carried out by using dextran 40 containing different fractions of red blood cells (RBCs). The in vitro blood flow was measured by means of video microscopy and image analysis. Additionally, the pressure drop was also measured.por
dc.identifier.citationGarcia, Valdemar; Dias, Ricardo P.; Correia, Teresa; Lima, Rui; Garcia, Valdemar; Dias, Ricardo P.; Correia, Teresa; Lima, Rui; Pinheiro, Elisa; Pinho, Diana; Rodrigues, Pedro (2010). In vitro blood flow in circular PDMS microchannels: effect of the flow rate and hematocrit. In 6th World Congress of Biomechanics Abstracts. Singapore.por
dc.identifier.urihttp://hdl.handle.net/10198/4686
dc.language.isoengpor
dc.peerreviewedyespor
dc.subjectBlood flowpor
dc.subjectPDMS microchannelspor
dc.titleIn vitro blood flow in circular PDMS microchannels: effect of the flow rate and hematocritpor
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceSingaporepor
oaire.citation.title6th World Congress of Biomechanics Abstractspor
person.familyNameGarcia
person.familyNameDias
person.familyNameCorreia
person.familyNameLima
person.familyNamePinho
person.familyNameRodrigues
person.givenNameValdemar
person.givenNameRicardo P.
person.givenNameTeresa Montenegro
person.givenNameRui A.
person.givenNameDiana
person.givenNamePedro João
person.identifier.ciencia-id1610-5AFD-75A1
person.identifier.ciencia-idEE12-C3FB-349D
person.identifier.ciencia-id5214-ED0C-35E8
person.identifier.ciencia-id1316-21BB-9015
person.identifier.orcid0000-0002-3941-2438
person.identifier.orcid0000-0003-1503-998X
person.identifier.orcid0000-0002-9640-8320
person.identifier.orcid0000-0003-3428-637X
person.identifier.orcid0000-0002-3884-6496
person.identifier.orcid0000-0002-0555-2029
person.identifier.ridK-2190-2014
person.identifier.ridH-5157-2016
person.identifier.scopus-author-id7102885151
person.identifier.scopus-author-id36607620800
person.identifier.scopus-author-id18437397800
rcaap.rightsopenAccesspor
rcaap.typeconferenceObjectpor
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