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Particulate blood analogues reproducing the erythrocytes cell-free layer in a microfluidic device containing a hyperbolic contraction

2016Journal article Open access
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dc.contributor.authorCalejo, Joana A.C.
dc.contributor.authorPinho, Diana
dc.contributor.authorGalindo-Rosales, Francisco J.
dc.contributor.authorLima, Rui A.
dc.contributor.authorCampo-Deaño, Laura
dc.date.accessioned2018-01-31T10:00:00Z
dc.date.accessioned2018-02-01T09:38:01Z
dc.date.available2018-01-31T10:00:00Z
dc.date.available2018-02-01T09:38:01Z
dc.date.issued2016
dc.description.abstractThe interest in the development of blood analogues has been increasing recently as a consequence of the increment in the number of experimental hemodynamic studies and the difficulties associated with the manipulation of real blood in vitro because of ethical, economical or hazardous issues. Although one-phase Newtonian and non-Newtonian blood analogues can be found in the literature, there are very few studies related to the use of particulate solutions in which the particles mimic the behaviour of the red blood cells (RBCs) or erythrocytes. One of the most relevant effects related with the behaviour of the erythrocytes is a cell-free layer (CFL) formation, which consists in the migration of the RBCs towards the center of the vessel forming a cell depleted plasma region near the vessel walls, which is known to happen in in vitro microcirculatory environments. Recent studies have shown that the CFL enhancement is possible with an insertion of contraction and expansion region in a straight microchannel. These effects are useful for cell manipulation or sorting in lab-on-chip studies. In this experimental study we present particulate Newtonian and non-Newton ian solutions which resulted in a rheological blood analogue able to form a CFL, downstream of a microfluidic hyperbolic contraction, in a similar way of the one formed by healthy RBCs.en_EN
dc.description.sponsorshipThe authors acknowledge the financial support provided by Fundação para a Ciência e a Tecnologia (FCT), COMPETE and FEDER through projects PTDC/SAU-BEB/105650/2008, PTDC/SAU-ENB/116929/2010, PTDC/EQU-FTT/118716/2010, EXPL/EMS-SIS/2215/2013, EXPL/EMS-TRA/2306/2013, fellowships SFRH/BD/89077/2012, SFRH/BPD/69663/2010 and SFRH/BPD/69664/2010 and grants IF/00148/2013 and IF/00190/2013.
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationCalejo, Joana; Pinho, Diana; Galindo-Rosales, Francisco J.; Lima, Rui; Campo-Deaño, Laura (2016). Particulate blood analogues reproducing the erythrocytes cell-free layer in a microfluidic device containing a hyperbolic contraction. Micromachines. ISSN 2072-666X. 7, p. 1-12en_EN
dc.identifier.doi10.3390/mi7010004en_EN
dc.identifier.issn2072-666X
dc.identifier.urihttp://hdl.handle.net/10198/15402
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.relationBIOMIMETIC - A biomimetic microdevice for the diagnosis of erythrocytes diseases based on their deformability
dc.relationRheoChip - Design of a rheometer-on-a-chip for the development of blood analogue solutions
dc.relationDEVELOPMENT AND OPTIMIZATION OF EXTENSIONAL-RHEOMETERS-ON-A-CHIP EXRHEC’S
dc.relationIMPACT OF THE NON-NEWTONIAN BLOOD RHEOLOGY ON HEMODYNAMIC FLOWS: APPLICATION TO CEREBRAL ANEURYSMS
dc.subjectBlood analogueen_EN
dc.subjectCell-free layeren_EN
dc.subjectHemodynamicsen_EN
dc.subjectMicrofluidicsen_EN
dc.subjectRheologyen_EN
dc.titleParticulate blood analogues reproducing the erythrocytes cell-free layer in a microfluidic device containing a hyperbolic contractionen_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleBIOMIMETIC - A biomimetic microdevice for the diagnosis of erythrocytes diseases based on their deformability
oaire.awardTitleRheoChip - Design of a rheometer-on-a-chip for the development of blood analogue solutions
oaire.awardTitleDEVELOPMENT AND OPTIMIZATION OF EXTENSIONAL-RHEOMETERS-ON-A-CHIP EXRHEC’S
oaire.awardTitleIMPACT OF THE NON-NEWTONIAN BLOOD RHEOLOGY ON HEMODYNAMIC FLOWS: APPLICATION TO CEREBRAL ANEURYSMS
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FSAU-BEB%2F105650%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FSAU-ENB%2F116929%2F2010/PT
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oaire.awardURIinfo:eu-repo/grantAgreement/FCT/COMPETE/EXPL%2FEMS-TRA%2F2306%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F89077%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F69663%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F69664%2F2010/PT
oaire.fundingStream5876-PPCDTI
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oaire.fundingStream5876-PPCDTI
oaire.fundingStreamCOMPETE
oaire.fundingStreamCOMPETE
oaire.fundingStreamSFRH
person.familyNamePinho
person.familyNameLima
person.givenNameDiana
person.givenNameRui A.
person.identifier.ciencia-id5214-ED0C-35E8
person.identifier.ciencia-idEE12-C3FB-349D
person.identifier.orcid0000-0002-3884-6496
person.identifier.orcid0000-0003-3428-637X
person.identifier.ridH-5157-2016
person.identifier.scopus-author-id18437397800
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.nameFundação para a Ciência e a Tecnologia
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project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
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