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Phenolic profile, antibacterial, antimutagenic and antitumour evaluation of Veronica urticifolia Jacq.

2014Journal article Open access
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dc.contributor.authorŽivković, Jelena
dc.contributor.authorBarreira, João C.M.
dc.contributor.authorStojković, Dejan
dc.contributor.authorCebovic, Tatjana
dc.contributor.authorSantos-Buelga, Celestino
dc.contributor.authorMaksimović, Zoran
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2014-08-13T11:40:54Z
dc.date.available2014-08-13T11:40:54Z
dc.date.issued2014
dc.description.abstractThis study was designed to characterize the phenolic profile and evaluate the antibacterial, antimutagenic and antitumor activities of Veronica urticifolia Jacq. methanolic extract. HPLC-DAD/ESI-MS analysis revealed the presence of phenolic acids, flavonoids and phenylethanoids, with acteoside as the main component (14.9 mg/g of extract). Antibacterial effect was determined using the microbroth dilution assay and Staphylococcus aureus was the most sensitive strain (MIC and MBC = 7.5 mg/mL). Antimutagenic activity was evaluated by Ames mutagenicity assay. At 1 mg/plate, the tested extract afforded high protection against the mutagenicity of nitroquinoline-N-oxide (4NQO) to Salmonella typhimurium strain TA100 (inhibition rate 48.3%). Antitumor activity was screened in Ehrlich ascites carcinoma (EAC) model. Pretreatment with 2 mg/kg body weight showed statistically significant decrease in tumor cell viability, while ascites volume and tumor cell count became slightly decreased, but not to a statistically significant extent. Above results indicate that V. urticifolia deserves further research into chemoprevention.por
dc.description.sponsorshipMinistry of Education, Science and Technological Development of Serbia for financial support, project number 173015. The authors are grateful to Fundação para a Ciência e a Tecnologia (FCT, Portugal) for financial support to CIMO (strategic project PEst-OE/AGR/UI0690/2011). J.C.M. Barreira thanks FCT, POPH-QREN and FSE for his grant (SFRH/BPD/72802/2010). The GIP-USAL is financially supported by the Spanish Government through the Consolider-Ingenio 2010 Programme (FUN-C-FOOD, CSD2007-00063) and project ref. BFU2012-35228por
dc.identifier.citationŽivkovic, Jelena; Barreira, João C.M.; Stojković, Dejan; Cebovic, Tatjana; Santos-Buelga, Celestino; Maksimovic, Zoran; Ferreira, Isabel C.F.R. (2014). Phenolic profile, antibacterial, antimutagenic and antitumour evaluation of Veronica urticifolia Jacq. Journal of Functional Foods. ISSN 1756-4646. 9:1, p. 192-201por
dc.identifier.doi10.1016/j.jff.2014.04.024
dc.identifier.issn1756-4646
dc.identifier.urihttp://hdl.handle.net/10198/10144
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevierpor
dc.relationStrategic Project - UI 690 - 2011-2012
dc.relationBIOACTIVE PROPERTIES & CYTOPROTECTIVE POTENTIAL OF NATURAL EXTRACTS/INDIVIDUAL COMPOUNDS: APPLICATION OF SINGLE CELL GEL ELECTROPHORESIS AND OTHER BIOCHEMICAL, CHEMICAL AND ELECTROCHEMICAL ASSAYS
dc.subjectVeronica urticifoliapor
dc.subjectPhenolic profilepor
dc.subjectHPLC-DAD/ESI-MSpor
dc.subjectAntibacterialpor
dc.subjectAntimutagenicitypor
dc.subjectEhrlich carcinomapor
dc.titlePhenolic profile, antibacterial, antimutagenic and antitumour evaluation of Veronica urticifolia Jacq.por
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleStrategic Project - UI 690 - 2011-2012
oaire.awardTitleBIOACTIVE PROPERTIES & CYTOPROTECTIVE POTENTIAL OF NATURAL EXTRACTS/INDIVIDUAL COMPOUNDS: APPLICATION OF SINGLE CELL GEL ELECTROPHORESIS AND OTHER BIOCHEMICAL, CHEMICAL AND ELECTROCHEMICAL ASSAYS
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FAGR%2FUI0690%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F72802%2F2010/PT
oaire.citation.endPage201por
oaire.citation.startPage192por
oaire.citation.titleJournal of Functional Foodspor
oaire.citation.volume9por
oaire.fundingStream6817 - DCRRNI ID
person.familyNameBarreira
person.familyNameFerreira
person.givenNameJoão C.M.
person.givenNameIsabel C.F.R.
person.identifier144781
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0003-1233-0990
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridD-8269-2013
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id54895546900
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspor
rcaap.typearticlepor
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relation.isAuthorOfPublicationbd0d1537-2e03-41fb-b27a-140af9c35db8
relation.isAuthorOfPublication.latestForDiscoverybd0d1537-2e03-41fb-b27a-140af9c35db8
relation.isProjectOfPublicationc59f09d4-9931-4f2e-babb-ef8bed998be7
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