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Antifungal activity of spent coffee ground extracts

2023Journal article Open access
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dc.contributor.authorCalheiros, Daniela
dc.contributor.authorDias, Maria Inês
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorBarros, Lillian
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorFernandes, Chantal
dc.contributor.authorGonçalves, Teresa
dc.date.accessioned2022-04-19T08:28:03Z
dc.date.available2022-04-19T08:28:03Z
dc.date.issued2023
dc.description.abstractCoffee is one of the most popular and consumed products in the world, generating tons of solid waste known as spent coffee grounds (SCG), containing several bioactive compounds. Here, the antifungal activity of ethanolic SCG extract from caffeinated and decaffeinated coffee capsules was evaluated against yeasts and filamentous fungi. These extracts had antifungal activity against Candida krusei, Candida parapsilosis, Trichophyton mentagrophytes, and Trichophyton rubrum, all skin fungal agents. Moreover, SCG had fungicidal activity against T. mentagrophytes and T. rubrum. To understand the underlying mechanisms of the antifungal activity, fungal cell membrane and cell wall components were quantified. SCG caused a significant reduction of the ergosterol, chitin, and β-(1,3)-glucan content of C. parapsilosis, revealing the synthesis of this membrane component and cell wall components as possible targets of these extracts. These extracts were cytotoxic for the tumoral cell lines tested but not for the non-tumoral PLP2 cell line. The analysis of the phenolic compounds of these extracts revealed the presence of caffeoylquinic acid, feruloylquinic acid, and caffeoylshikimic acid derivatives. Overall, this confirmed the antifungal activity of spent coffee grounds, presenting a potential increase in the sustainability of the life cycle of coffee grounds, as a source for the development of novel antifungal formulations, especially for skin or mucosal fungal infections.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCalheiros, Daniela; Dias, Maria Inês; Calhelha, Ricardo C.; Barros, Lillian; Ferreira, Isabel C.F.R.; Fernandes, Chantal; Gonçalves, Teresa (2023). Antifungal activity of spent coffee ground extracts. Microorganisms. eISSN 2076-2607. 11:2, p. 1-20pt_PT
dc.identifier.doi10.3390/microorganisms11020242
dc.identifier.eissn2076-2607
dc.identifier.urihttp://hdl.handle.net/10198/25381
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectSpent coffee grounds (SCG)pt_PT
dc.subjectNatural extractspt_PT
dc.subjectAntifungal activitypt_PT
dc.subjectCandida spp.pt_PT
dc.subjectTrichophyton spp.
dc.titleAntifungal activity of spent coffee ground extractspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleMicroorganismspt_PT
person.familyNameDias
person.familyNameCalhelha
person.familyNameBarros
person.familyNameFerreira
person.givenNameMaria Inês
person.givenNameRicardo C.
person.givenNameLillian
person.givenNameIsabel C.F.R.
person.identifier469085
person.identifier144781
person.identifier.ciencia-id2A13-4BE6-C7CF
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person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridM-8242-2013
person.identifier.ridJ-2172-2014
person.identifier.ridJ-3600-2013
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id54388787000
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id36868826600
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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