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Generation of micro-sized PDMS particles by a flow focusing technique for biomicrofluidics applications

dc.contributor.authorMuñoz-Sánchez, Beatriz N.
dc.contributor.authorSilva, Filipa Silva
dc.contributor.authorPinho, Diana
dc.contributor.authorVega, E.J.
dc.contributor.authorLima, Rui A.
dc.date.accessioned2018-01-31T10:00:00Z
dc.date.accessioned2018-02-01T09:38:03Z
dc.date.available2018-01-31T10:00:00Z
dc.date.available2018-02-01T09:38:03Z
dc.date.issued2016
dc.description.abstractPolydimethylsiloxane (PDMS), due to its remarkable properties, is one of the most widely used polymers in many industrial and medical applications. In this work, a technique based on a flow focusing technique is used to produce PDMS spherical particles with sizes of a few microns. PDMS precursor is injected through a hypodermic needle to form a film/reservoir over the needle's outer surface. This film flows towards the needle tip until a liquid ligament is steadily ejected thanks to the action of a coflowing viscous liquid stream. The outcome is a capillary jet which breaks up into PDMS precursor droplets due to the growth of capillary waves producing a micrometer emulsion. The PDMS liquid droplets in the solution are thermally cured into solid microparticles. The size distribution of the particles is analyzed before and after curing, showing an acceptable degree of monodispersity. The PDMS liquid droplets suffer shrinkage while curing. These microparticles can be used in very varied technological fields, such as biomedicine, biotechnology, pharmacy, and industrial engineering.en_EN
dc.description.sponsorshipThe authors acknowledge the financial support provided by Fundação para a Ciência e a Tecnologia (FCT), COMPETE and FEDER through the Projects PTDC/SAU-ENB/116929/2010, EXPL/EMS-SIS/2215/2013, PTDC/QEQ-FTT/4287/2014 and fellowship SFRH/BD/89077/2012. Partial support from the spanish Ministry of Science and Education (Grant No. DPI2013-46485), Junta de Extremadura (Grant No. GR10047), and “la Caixa” Foundation (predoctoral grant) is gratefully acknowledged too. Finally, we thank Jos e M. Montanero for his helpful suggestions and discussion on the results.
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationMuñoz-Sánchez, B. N.; Silva, S. F.; Pinho, D.; Vega, E. J.; Lima, R. (2016). Generation of micro-sized PDMS particles by a flow focusing technique for biomicrofluidics applications. Biomicrofluidics. ISSN 1932-1058. 10, p. 1-11en_EN
dc.identifier.doi10.1063/1.4943007en_EN
dc.identifier.issn1932-1058
dc.identifier.urihttp://hdl.handle.net/10198/15405
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.relationBIOMIMETIC - A biomimetic microdevice for the diagnosis of erythrocytes diseases based on their deformability
dc.titleGeneration of micro-sized PDMS particles by a flow focusing technique for biomicrofluidics applicationsen_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleBIOMIMETIC - A biomimetic microdevice for the diagnosis of erythrocytes diseases based on their deformability
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FSAU-ENB%2F116929%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/COMPETE/EXPL%2FEMS-SIS%2F2215%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FQEQ-FTT%2F4287%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F89077%2F2012/PT
oaire.fundingStream5876-PPCDTI
oaire.fundingStreamCOMPETE
oaire.fundingStream9471 - RIDTI
oaire.fundingStreamSFRH
person.familyNamePinho
person.familyNameLima
person.givenNameDiana
person.givenNameRui A.
person.identifier.ciencia-id5214-ED0C-35E8
person.identifier.ciencia-idEE12-C3FB-349D
person.identifier.orcid0000-0002-3884-6496
person.identifier.orcid0000-0003-3428-637X
person.identifier.ridH-5157-2016
person.identifier.scopus-author-id18437397800
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
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