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Phenolic profiling and in vitro bioactivities of three medicinal Bryophyllum plants

2021Journal article Open access
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dc.contributor.authorGarcía-Pérez, Pascual
dc.contributor.authorAyuso, Manuel
dc.contributor.authorLozano-Milo, Eva
dc.contributor.authorPereira, Carla
dc.contributor.authorDias, Maria Inês
dc.contributor.authorIvanov, Marija
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorSoković, Marina
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorBarros, Lillian
dc.contributor.authorGallego, Pedro Pablo
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2021-11-23T12:12:49Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2021-11-23T12:12:49Z
dc.date.issued2021
dc.description.abstractBryophyllum constitutes a subgenus within the genus Kalanchoe that contains several plant species used in traditional medicine worldwide for the treatment of several diseases. However, little is known about the phytoconstituents of Bryophyllum spp. and previous reports have pointed at their low in Planta concentrations of bioactive compounds. In this work, we take advantage of plant in vitro culture for the study of the phenolic compounds found in the aerial parts of Bryophyllum spp. and their associated bioactivities. Our results show that the induction of nutritional stress leads to an improved accumulation of phenolic compounds, mainly flavonols and anthocyanins, represented by myricetin and malvidin glycosides, respectively. This effect is mainly found for B. × houghtonii, whose hydroethanolic extracts promoted the highest antioxidant, cytotoxic and anti-inflammatory activities. In the case of cytotoxic activity, Bryophyllum extracts showed an enhanced activity against the MCF-7 human breast carcinoma cell line. Meanwhile, extracts from B. daigremontianum promoted a wide range of effectiveness against different bacterial and fungal strains. This study is committed to shed light about the phytochemical potential associated to this unexplored subgenus, with the aim of considering Bryophyllum spp. as a valuable source of bioactive compounds for their exploitation in food, cosmetic and pharmaceutical industries.en_EN
dc.description.sponsorshipThe authors acknowledge the Spanish Ministry of Education for the FPU grant awarded to Pascual García-Pérez (FPU15/04849) and ADICAM research center for kindly providing the plant material.
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationGarcía-Pérez, Pascual; Ayuso, Manuel; Lozano-Milo, Eva; Pereira, Carla; Dias, Maria Inês; Ivanov, Marija; Calhelha, Ricardo C.; Soković, Marina; Ferreira, Isabel C.F.R.; Barros, Lillian; Gallego, Pedro P. (2021). Phenolic profiling and in vitro bioactivities of three medicinal Bryophyllum plants. Industrial Crops and Products. ISSN 0926-6690. 162, p. 1-9en_EN
dc.identifier.doi10.1016/j.indcrop.2021.113241en_EN
dc.identifier.issn0926-6690
dc.identifier.urihttp://hdl.handle.net/10198/24374
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.subjectAnthocyaninsen_EN
dc.subjectBioactive propertiesen_EN
dc.subjectFlavonoidsen_EN
dc.subjectKalanchoe plant in vitro cultureen_EN
dc.subjectPhytochemical potentialen_EN
dc.titlePhenolic profiling and in vitro bioactivities of three medicinal Bryophyllum plantsen_EN
dc.typejournal article
dspace.entity.typePublication
person.familyNameAyuso
person.familyNamePereira
person.familyNameDias
person.familyNameCalhelha
person.familyNameFerreira
person.familyNameBarros
person.givenNameManuel
person.givenNameCarla
person.givenNameMaria Inês
person.givenNameRicardo C.
person.givenNameIsabel C.F.R.
person.givenNameLillian
person.identifierABC-7764-2020
person.identifier1415151
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person.identifier.ciencia-idF313-E3CE-554E
person.identifier.ciencia-id9418-CF95-9919
person.identifier.ciencia-id9616-35CB-D001
person.identifier.orcid0000-0002-1697-3857
person.identifier.orcid0000-0003-0093-771X
person.identifier.orcid0000-0001-8744-7814
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0003-4910-4882
person.identifier.orcid0000-0002-9050-5189
person.identifier.ridK-1629-2016
person.identifier.ridM-8242-2013
person.identifier.ridJ-2172-2014
person.identifier.ridE-8500-2013
person.identifier.ridJ-3600-2013
person.identifier.scopus-author-id55627876424
person.identifier.scopus-author-id54388787000
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id36868826600
person.identifier.scopus-author-id35236343600
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
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