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In vitro evaluation of portuguese propolis and floral sources for antiprotozoal, antibacterial and antifungal activity

2014Journal article Open access
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dc.contributor.authorFalcão, Soraia
dc.contributor.authorVale, Nuno
dc.contributor.authorCos, Paul
dc.contributor.authorGomes, Paula
dc.contributor.authorFreire, Cristina
dc.contributor.authorMaes, Louis
dc.contributor.authorVilas-Boas, Miguel
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2018-03-08T15:14:53Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2018-03-08T15:14:53Z
dc.date.issued2014
dc.description.abstractPropolis is a beehive product with a very complex chemical composition, used since ancient times in several therapeutic treatments. As a contribution to the improvement of drugs against several tropical diseases caused by protozoa, we screened Portuguese propolis and its potential floral sources Populus x Canadensis and Cistus ladanifer against Plasmodium falciparum, Leishmania infantum, Trypanosoma brucei and Trypanosoma cruzi. The toxicity against MRC-5 fibroblast cells was evaluated to assess selectivity. The in vitro assays were performed following the recommendations of WHO Special Programme for Research and Training in Tropical Diseases (TDR) and revealed moderate activity, with the propolis extracts presenting the relatively highest inhibitory effect against T. brucei. Additionally, the antimicrobial activity against Staphylococcus aureus, Candida albicans, Trichophyton rubrum and Aspergillus fumigatus was also verified with the better results observed against T. rubrum. The quality of the extracts was controlled by evaluating the phenolic content and antioxidant activity. The observed biological activity variations are associated with the variable chemical composition of the propolis and the potential floral sources under study.en_EN
dc.description.sponsorshipSoraia I. Falcão thanks FCT for the PhD grant SFRH/BD/44855/2008. N. Vale thanks FCT for the Post-Doc grant SFRH/BPD/48345/2008. Thanks also to FCT for financial support provided to CIMO (PEst-OE/ AGR/UI0690/2011) and CIQ-UP (PEst-C/QUI/UI0081/2011). Thanks are due to the National Federation of Portuguese Beekeepers, for supplying propolis samples.
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationFalcão, Soraia I.; Vale, Nuno; Cos, Paul; Gomes, Paula; Freire, Cristina; Maes, Louis; Vilas-Boas, Miguel (2014). In vitro evaluation of portuguese propolis and floral sources for antiprotozoal, antibacterial and antifungal activity. Phytotherapy Research. ISSN 0951-418X. 28, p. 437-443en_EN
dc.identifier.doi10.1002/ptr.5013en_EN
dc.identifier.issn0951-418X
dc.identifier.urihttp://hdl.handle.net/10198/16227
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.relationAUTENTICAÇÃO GEOGRÁFICA DO MEL E PROPOLIS PORTUGUÊS PELA CARACTERIZAÇÃO QUÍMICA DO PERFIL FENÓLICO. POTENCIALIDADES ANTIOXIDANTES
dc.relationStrategic Project - UI 690 - 2011-2012
dc.relationStrategic Project - UI 81 - 2011-2012
dc.subjectAntimicrobial activityen_EN
dc.subjectAntioxidant activityen_EN
dc.subjectAntiprotozoal activityen_EN
dc.subjectPhenolic compoundsen_EN
dc.subjectPropolisen_EN
dc.titleIn vitro evaluation of portuguese propolis and floral sources for antiprotozoal, antibacterial and antifungal activityen_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAUTENTICAÇÃO GEOGRÁFICA DO MEL E PROPOLIS PORTUGUÊS PELA CARACTERIZAÇÃO QUÍMICA DO PERFIL FENÓLICO. POTENCIALIDADES ANTIOXIDANTES
oaire.awardTitleStrategic Project - UI 690 - 2011-2012
oaire.awardTitleStrategic Project - UI 81 - 2011-2012
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F44855%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F48345%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FAGR%2FUI0690%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6820 - DCRRNI ID/PEst-C%2FQUI%2FUI0081%2F2011/PT
oaire.fundingStreamSFRH
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6820 - DCRRNI ID
person.familyNameFalcão
person.familyNameVilas-Boas
person.givenNameSoraia
person.givenNameMiguel
person.identifier711432
person.identifier1693134
person.identifier.ciencia-idD41A-6BED-4CBB
person.identifier.ciencia-idA918-C6FF-81A4
person.identifier.orcid0000-0003-3735-6951
person.identifier.orcid0000-0002-8665-5280
person.identifier.ridI-5949-2013
person.identifier.scopus-author-id14832459200
person.identifier.scopus-author-id6602648497
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
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