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The effects of long-term chaetomellic acid a administration on renal function and oxidative stress in a rat model of renal mass reduction

2017Journal article Open access
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dc.contributor.authorNogueira, António José M.
dc.contributor.authorPeixoto, Francisco P.
dc.contributor.authorOliveira, Maria Manuel
dc.contributor.authorPires, Carlos André
dc.contributor.authorColaço, Bruno Jorge
dc.contributor.authorOliveira, Paula A.
dc.contributor.authorPires, Maria João
dc.date.accessioned2018-01-25T10:00:00Z
dc.date.accessioned2018-02-02T10:39:45Z
dc.date.available2018-01-25T10:00:00Z
dc.date.available2018-02-02T10:39:45Z
dc.date.issued2017
dc.description.abstractThis study aimed to evaluate the effect of chronic treatment with chaetomellic acid A (CAA) on oxidative stress and renal function in amodel of renalmass reduction. Methods.MaleWistar ratswere subjected to 5/6 nephrectomy (RMR) or sham-operated (SO). One week after surgery, rats have been divided into four experimental groups: RMR: RMR rats without treatment (n = 14); RMR + CAA: RMR rats treated with CAA (n = 13); SO: SO rats without treatment (n = 13); and SO + CAA: SO rats treated with CAA (n = 13). CAA was intraperitoneally administered in a dose of 0.23 μg/Kg three times a week for six months. Results. RMR was accompanied by a significant reduction in catalase and glutathione reductase (GR) activity (p < 0.05) and a decrease in reduced glutathione (GSH)/oxidized glutathione (GSSG) ratio. CAAadministration significantly increased catalase andGR activity (p < 0.05) and increased GSH/GSSG ratio, but no significant difference between the treated and nontreated groups was found in this ratio.No significant differences were found between theRMRgroups in any of the parameters of renal function.However, CAA administration slightly improves some parameters of renal function. Conclusions. These data suggest that CAA could attenuate 5/6 RMR-induced oxidative stress.en_EN
dc.description.sponsorshipThe authors would like to thank Jos´e Miguel Lopez- Novoa for valuable comments and suggestions. This work is supported by European Investment Funds by FEDER/ COMPETE/POCI, Operational Competitiveness and Internationalization Programme, under Project POCI-01-0145- FEDER-006958, and National Funds by FCT, Portuguese Foundation for Science and Technology, under Project UID/AGR/04033/2013, and by European Investment Funds by FEDER/COMPETE/POCI, Operational Competitiveness and Internationalization Programme, under Project POCI- 01-0145-FEDER-016728, and National Funds by FCT, Portuguese Foundation for Science and Technology, under Project PTDC/DTP-DES/6077/2014.
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationNogueira, António; Peixoto, Francisco; Oliveira, Maria Manuel; Pires, Carlos André; Colaço, Bruno; Oliveira, Paula Alexandra; Pires, Maria João (2017). The effects of long-term chaetomellic acid a administration on renal function and oxidative stress in a rat model of renal mass reduction. BioMed Research International. ISSN 2314-6133. 2017, p.en_EN
dc.identifier.doi10.1155/2017/5125980en_EN
dc.identifier.issn2314-6133
dc.identifier.urihttp://hdl.handle.net/10198/15506
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.relationRUNNING away from prostate cancer: WALKING through the molecular basis of physical activity
dc.titleThe effects of long-term chaetomellic acid a administration on renal function and oxidative stress in a rat model of renal mass reductionen_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleRUNNING away from prostate cancer: WALKING through the molecular basis of physical activity
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FAGR%2F04033%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FDTP-DES%2F6077%2F2014/PT
oaire.fundingStream5876
oaire.fundingStream9471 - RIDTI
person.familyNameNogueira
person.givenNameAntónio José M.
person.identifier.ciencia-id8A11-794E-36BD
person.identifier.orcid0000-0001-8912-7355
person.identifier.scopus-author-id55865568268
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
relation.isAuthorOfPublication648209a2-eec9-4bec-975a-32673e41b95c
relation.isAuthorOfPublication.latestForDiscovery648209a2-eec9-4bec-975a-32673e41b95c
relation.isProjectOfPublication3acb07e1-8183-43b8-8dfc-c0187a8741be
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relation.isProjectOfPublication.latestForDiscovery3acb07e1-8183-43b8-8dfc-c0187a8741be

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