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Bioactive properties of medicinal plants from the Algerian flora: selecting the species with the highest potential in view of application purposes

2015Journal article Open access
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dc.contributor.authorZiani, Borhane E.C.
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorBarreira, João C.M.
dc.contributor.authorBarros, Lillian
dc.contributor.authorHazzit, Mohamed
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2015-12-01T11:03:07Z
dc.date.available2015-12-01T11:03:07Z
dc.date.issued2015
dc.description.abstractThe Algerian flora contains a wide variety of plant species with potential to be used in medicinal applications. Herein, the bioactive properties of medicinal plants from Algeria were evaluated to select the species with highest suitability to be used under specific purposes, while scientifically validating their health claims. The antioxidant activity of the infusions was screened by using several tests and cytotoxic properties were evaluated against human tumor cell lines (as also against non-tumor cells). Different hydrophilic bioactive compounds were also quantified. The results were analyzed considering individual variations in each parameter (ANOVA), but also in an aggregated approach by applying principal component analysis to acquire a comprehensive knowledge regarding the overall bioactive potential of the studied species. Limoniastrum guyonianum and Thymus pallescens showed the highest antioxidant activity (EC50 values ranging from 29 to 229 μg/mL and 54 to 240 μg/mL, respectively), whilst Asteriscus graveolens and L. guyonianum gave the best cytotoxicity against human tumor cell lines (GI50 values ranging from 11 to 29 μg/mL and 22 to 70 μg/mL, respectively). T. pallescens stood out as the species with highest bioactive compounds contents (phenols: 463 mg GAE, flavonoids: 194 mg CE, esters; 186 mg CAE; flavonols: 85 mg QE, considering g of lyophilized infusion basis). From a global point of view, T. pallescens, Saccocalyx satureioides and Ptychotis verticillata proved to be the preferable choices as high potential sources of bioactive compounds, while Haloxylon scoparium, L. guyonianum and A. graveolens would be the most suitable matrices considering the bioactivity (especially cytotoxicity) criterion, as inferred from the PCA outputs.pt_PT
dc.description.sponsorshipThe authors are grateful to the Foundation for Science and Technology (FCT, Portugal) for financial support to CIMO (PEst-OE/AGR/UI0690/2014), R.C. Calhelha (SFRH/BPD/68344/2010), J.C.M. Barreira (SFRH/BPD/72802/2010) and L. Barros (“Compromisso para a Ciência 2008” contract).pt_PT
dc.identifier.citationZiania, Borhane E.C.; Calhelha, Ricardo C.; Barreira, João C.M.; Barros, Lillian; Hazzit, Mohamed; Ferreira, Isabel C.F.R. (2015). Bioactive properties of medicinal plants from the Algerian flora: selecting the species with the highest potential in view of application purposes. Industrial Crops and Products. ISSN 0926-6690. 77, p. 582–589pt_PT
dc.identifier.doi10.1016/j.indcrop.2015.09.034pt_PT
dc.identifier.issn0926-6690
dc.identifier.urihttp://hdl.handle.net/10198/12464
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationBIOACTIVE PROPERTIES & CYTOPROTECTIVE POTENTIAL OF NATURAL EXTRACTS/INDIVIDUAL COMPOUNDS: APPLICATION OF SINGLE CELL GEL ELECTROPHORESIS AND OTHER BIOCHEMICAL, CHEMICAL AND ELECTROCHEMICAL ASSAYS
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAlgerian florapt_PT
dc.subjectHydrophilic extractspt_PT
dc.subjectAntioxidant activitypt_PT
dc.subjectAntitumor activitypt_PT
dc.subjectBioactive compoundspt_PT
dc.titleBioactive properties of medicinal plants from the Algerian flora: selecting the species with the highest potential in view of application purposespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleBIOACTIVE PROPERTIES & CYTOPROTECTIVE POTENTIAL OF NATURAL EXTRACTS/INDIVIDUAL COMPOUNDS: APPLICATION OF SINGLE CELL GEL ELECTROPHORESIS AND OTHER BIOCHEMICAL, CHEMICAL AND ELECTROCHEMICAL ASSAYS
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/PEst-OE%2FAGR%2FUI0690%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F68344%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F72802%2F2010/PT
oaire.citation.endPage589pt_PT
oaire.citation.startPage582pt_PT
oaire.citation.titleIndustrial Crops and Productspt_PT
oaire.citation.volume77pt_PT
oaire.fundingStream5876
oaire.fundingStreamSFRH
person.familyNameCalhelha
person.familyNameBarreira
person.familyNameBarros
person.familyNameFerreira
person.givenNameRicardo C.
person.givenNameJoão C.M.
person.givenNameLillian
person.givenNameIsabel C.F.R.
person.identifier469085
person.identifier144781
person.identifier.ciencia-idF313-E3CE-554E
person.identifier.ciencia-id9616-35CB-D001
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0003-1233-0990
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridJ-2172-2014
person.identifier.ridD-8269-2013
person.identifier.ridJ-3600-2013
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id54895546900
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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