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Bioactive properties and phenolic composition of Cynara cardunculus L. var. altilis: influence of the plant part collected at the same maturity stage

2020Conference object Open access
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dc.contributor.authorMandim, Filipa
dc.contributor.authorPetropoulos, Spyridon Α.
dc.contributor.authorDias, Maria Inês
dc.contributor.authorPinela, José
dc.contributor.authorKostić, Marina
dc.contributor.authorSoković, Marina
dc.contributor.authorBarros, Lillian
dc.contributor.authorSantos-Buelga, Celestino
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2022-01-21T12:16:19Z
dc.date.available2022-01-21T12:16:19Z
dc.date.issued2020
dc.description.abstractThe planet’s resources are increasingly scarce, a reason why their most efficient use is gaining more atten- tion. Several studies have shown the influence of genetic background, environmental conditions, and different plant tissues on the polyphenolic composition and consequently on its bioactive potential, leading to different industrial applications.1 Cynara cardunculus L. (Asteraceae), commonly known as cardoon, is a Mediterranean herbaceous plant with important economic value as a result of its diversified industrial applications (i.e. pro- duction of biomass, bioenergy, paper pulp, pharmaceutics and cosmetics).1,2 The present work aims to valorize underused parts of cardoon by evaluating the phenolic profile and bioactive properties of different plant tissues. Petioles, blades, heads, bracts, and seeds from a Greek cardoon genotype were collected at different growth stages throughout the growing season depending on the plant part, e.g. petioles and blades were col- lected throughout the growing season, heads and bracts during the flowering stage and seeds after seed for- mation and until the seed ripening stage. The phenolic profile was determined by HPLC-DAD-ESI/MS and the antioxidant activity were measured through cell-based assays, namely TBARS and OxHLIA. Cytotoxic effects were screened in four human tumor cell lines and hepatotoxicity in a non-tumor cell line (PLP2) by the sul- forhodamine B assay. Anti-inflammatory potential was tested through the inhibition of NO production. Finally, the antibacterial and antifungal activities were evaluated by the broth microdilution method. The blades of car- doon presented the highest bioactive activity and variety in phenolic compounds. Considering the maturation stage, the bracts stand out at the intermediate stage, showing a higher antioxidant potential for TBARS assay, and the petioles a higher anti-inflammatory activity. In turn, at the most advanced stage of maturity, the seeds presented lower EC50 values in the OxHLIA assay. More immature plant tissues presented a higher content in phenolic compounds, and as expected, higher antioxidant activity in the OxHLIA assay. The most advanced states of maturation also presented highest cytotoxic and anti-inflammatory activity. For the antibacterial and antifungal activities, the results obtained were not affected by different plant parts or by the maturation stages studied. The results obtained in the present work, allows us to choose the best harvesting time of cardoon, allowing achieving a greater variety of phenolic compounds, and consequently, a highest bioactive potential, and ultimately the most appropriate use of their constituents. Nevertheless, further studies are needed to better understand the compounds responsible for the observed activities.pt_PT
dc.description.sponsorshipTo the Foundation for Science and Technology (FCT, Portugal) and FEDER under Programme PT2020 for financial support to CIMO (UID/AGR/00690/2019); PhD grant of Filipa Mandim (SFRH/146614/2019); and M.I. Dias, Â. Fernandes, J. Pinela, and L. Barros contracts. Also, to FEDER-Interreg España-Portugal programme for financial support through the project 0377_Iberphenol_6_E and TRANSCoLAB 0612_TRANS_CO_LAB_2_P.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMandim, Filipa; Petropoulos, Spyridon Α.; Dias, Maria Inês; Pinela, José; Kostić, Marina; Soković, Marina; Barros, Lillian; Santos-Buelga, Celestino; Ferreira, Isabel C.F.R. (2020). Bioactive properties and phenolic composition of Cynara cardunculus L. var. altilis: influence of the plant part collected at the same maturity stage. In IberPhenol international Conference. Coimbra
dc.identifier.urihttp://hdl.handle.net/10198/24823
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationSFRH/146614/2019
dc.relationMountain Research Center
dc.titleBioactive properties and phenolic composition of Cynara cardunculus L. var. altilis: influence of the plant part collected at the same maturity stagept_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleMountain Research Center
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.citation.titleIberphenol International Conferencept_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameMandim
person.familyNameDias
person.familyNamePinela
person.familyNameBarros
person.familyNameFerreira
person.givenNameFilipa
person.givenNameMaria Inês
person.givenNameJosé
person.givenNameLillian
person.givenNameIsabel C.F.R.
person.identifier469085
person.identifier144781
person.identifier.ciencia-idF318-9049-EB99
person.identifier.ciencia-id2A13-4BE6-C7CF
person.identifier.ciencia-id771C-2B43-B108
person.identifier.ciencia-id9616-35CB-D001
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0002-6494-2326
person.identifier.orcid0000-0001-8744-7814
person.identifier.orcid0000-0001-7523-1637
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridM-8242-2013
person.identifier.ridB-4466-2014
person.identifier.ridJ-3600-2013
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id54388787000
person.identifier.scopus-author-id54392272800
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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