Publicação
The diversity of insecticide target site mutations in Apis mellifera
| datacite.subject.fos | Ciências Naturais::Ciências da Terra e do Ambiente | |
| datacite.subject.fos | Ciências Agrárias::Biotecnologia Agrária e Alimentar | |
| datacite.subject.sdg | 04:Educação de Qualidade | |
| datacite.subject.sdg | 02:Erradicar a Fome | |
| datacite.subject.sdg | 13:Ação Climática | |
| datacite.subject.sdg | 15:Proteger a Vida Terrestre | |
| dc.contributor.author | Verbinnen, Gilles | |
| dc.contributor.author | De Smet, Lina | |
| dc.contributor.author | Henriques, Dora | |
| dc.contributor.author | Tytgat, Jan | |
| dc.contributor.author | Pinto, M. Alice | |
| dc.contributor.author | Graaf, Dirk C. de | |
| dc.date.accessioned | 2026-02-12T11:18:53Z | |
| dc.date.available | 2026-02-12T11:18:53Z | |
| dc.date.issued | 2026 | |
| dc.description.abstract | Insecticides are widely used to combat agricultural pest species, such as aphids, caterpillars, planthoppers and locusts, or to limit the spread of disease-carrying mosquitos. However, these insecticides do not only affect their target species but also non-target species such as pollinators which inadvertently encounter them while foraging. Over one hundred different pesticides and pesticide derivatives have been found in honey bee hives. Insecticides are one of the factors behind the decline of pollinator populations. Pest species, such as aphids and Lepidoptera, have developed widespread resistance to a large number of compounds. However, research on insecticide resistance in honey bees is rather limited and focuses on only one type of resistance: metabolic resistance. Therefore, we aim to expand the available data on insecticide resistance in honey bees by studying another type of insecticide resistance: target site resistance. In this study, we screened 4897 publicly available Apis mellifera genomes for mutations in 17 insecticide target site genes covering all commonly used insecticides. These genomes originated from 54 countries and cover more than 20 subspecies and honey bee breeds. A total of 5269 synonymous and 4465 non-synonymous mutations were identified. These mutations show differing geographical and functional patterns of diversity. While the majority of mutations were classified as rare mutations or could not be linked directly to insecticide resistance, several potential insecticide resistance mutations have been identified. Furthermore, mutations potentially associated with previously reported local adaptation to high altitude and Varroa destructor are described. This study serves as a basis for further research on insecticide resistance and local adaptation in pollinators. | eng |
| dc.identifier.citation | Verbinnen, Gilles; De Smet, Lina; Henriques, Dora; Tytgat, Jan; Pinto, M. Alice; Graaf, Dirk C. de (2025). The diversity of insecticide target site mutations in Apis mellifera. Apimondia 2025. p. 369 | |
| dc.identifier.uri | http://hdl.handle.net/10198/35725 | |
| dc.language.iso | eng | |
| dc.peerreviewed | yes | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | Insecticides | |
| dc.subject | Pollinator populations | |
| dc.subject | Apis mellifera | |
| dc.title | The diversity of insecticide target site mutations in Apis mellifera | eng |
| dc.type | conference object | |
| dspace.entity.type | Publication | |
| oaire.citation.conferenceDate | 2025 | |
| oaire.citation.conferencePlace | Copenhagen, Denmark | |
| oaire.citation.startPage | 369 | |
| oaire.citation.title | Apimondia 2025 | |
| oaire.version | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |
| person.familyName | Henriques | |
| person.familyName | Pinto | |
| person.givenName | Dora | |
| person.givenName | M. Alice | |
| person.identifier.ciencia-id | 291F-986F-07DA | |
| person.identifier.ciencia-id | F814-A1D0-8318 | |
| person.identifier.orcid | 0000-0001-7530-682X | |
| person.identifier.orcid | 0000-0001-9663-8399 | |
| person.identifier.scopus-author-id | 55761737300 | |
| person.identifier.scopus-author-id | 8085507800 | |
| relation.isAuthorOfPublication | d2abd09f-a90c-4cfb-9a60-7fc32f56184d | |
| relation.isAuthorOfPublication | 0667fe04-7078-483d-9198-56d167b19bc5 | |
| relation.isAuthorOfPublication.latestForDiscovery | d2abd09f-a90c-4cfb-9a60-7fc32f56184d |