Repository logo
 
Publication

Lutein-loaded nanoparticles reverse oxidative stress, apoptosis, and autism spectrum disorder-like behaviors induced by prenatal valproic acid exposure in female rats

2023Journal article Open access
Simple item page
dc.contributor.authorViana, Cristini Escobar
dc.contributor.authorBortolotto, Vandreza Cardoso
dc.contributor.authorAraujo, Stifani Machado
dc.contributor.authorDahleh, Mustafa Munir
dc.contributor.authorMachado, Franciele Romero
dc.contributor.authorPereira, Adson de Souza
dc.contributor.authorOliveira, Byanca Pereira Moreira de
dc.contributor.authorLeimann, Fernanda Vitória
dc.contributor.authorGonçalves, Odinei Hess
dc.contributor.authorPrigol, Marina
dc.contributor.authorGuerra, Gustavo Petri
dc.date.accessioned2014-09-16T08:28:01Z
dc.date.available2014-09-16T08:28:01Z
dc.date.issued2023
dc.description.abstractAutism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social interaction and repetitive behaviors. In this study, we assessed the effect of lutein-loaded nanoparticles on ASD-like be-haviors induced by prenatal valproic acid (VPA) exposure in female offspring rats and the possible involvement of oxidative stress and apoptosis. Pregnant female Wistar rats received a single intraperitoneal injection of VPA (600 mg/kg), on the gestational day 12.5. The VPA-exposed female offspring rats were divided into two sub-groups and received either lutein-loaded nanoparticles (5 mg/kg) or saline by oral gavage, for 14 days. The animals were submitted to the three-chamber test and open field to evaluate ASD-like behaviors. The hippo -campus was removed for the determination of oxidative stress indicators (ROS; TBARS; SOD and Nrf2) and apoptosis biomarkers (Hsp-70; p38-MAPK; Bax and Bcl-2). The exposure to lutein-loaded nanoparticles reversed sociability deficit, social memory deficit, and anxiety-like and repetitive behaviors induced by VPA, and restored the oxidative stress indicators and apoptosis biomarkers in the hippocampus. This neurochemical effect must be associated with the reversal of ASD-like behaviors. These results provide evidence that lutein-loaded nano -particles are an alternative treatment for VPA-induced behavioral damage in female rats and suggest the involvement of oxidative stress.
dc.identifier.citationViana, Cristini Escobar; Bortolotto, Vandreza Cardoso; Araujo, Stifani Machado; Dahleh, Mustafa Munir; Machado, Franciele Romero; Pereira, Adson de Souza; Oliveira, Byanca Pereira Moreira de; Leimann, Fernanda Vitória; Goncalves, Odinei Hess; Prigol, Marina; Guerra, Gustavo Petri. (2023). Lutein-loaded nanoparticles reverse oxidative stress, apoptosis, and autism spectrum disorder-like behaviors induced by prenatal valproic acid exposure in female rats. Neurotoxicology. eISSN 1872-9711. 94, p. 223-234por
dc.identifier.doi10.1016/j.neuro.2022.12.006
dc.identifier.eissn1872-9711
dc.identifier.issn0161-813X
dc.identifier.urihttp://hdl.handle.net/10198/10450
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevierpor
dc.subjectNeurodevelopmental disorder
dc.subjectCarotenoid
dc.subjectSocial memory
dc.subjectNanoencapsulation
dc.subjectSociability
dc.subjectRepetitive behaviors
dc.titleLutein-loaded nanoparticles reverse oxidative stress, apoptosis, and autism spectrum disorder-like behaviors induced by prenatal valproic acid exposure in female ratspor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleNeurotoxicologypor
person.familyNameLeimann
person.familyNameGonçalves
person.givenNameFernanda Vitória
person.givenNameOdinei Hess
person.identifier.ciencia-id8F10-A04D-FC0D
person.identifier.orcid0000-0001-6230-9597
person.identifier.orcid0000-0002-9528-8187
person.identifier.scopus-author-id9335958400
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublicationb1102a0b-38dc-4caa-baed-ad52ccd9b230
relation.isAuthorOfPublication84c8eea0-77bb-4c18-b9d8-46f865980706
relation.isAuthorOfPublication.latestForDiscoveryb1102a0b-38dc-4caa-baed-ad52ccd9b230

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Lutein-loaded nanoparticles reverse oxidative stress.pdf
Size:
4.61 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.75 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

CIMO - Artigos em Revistas Indexados à WoS/Scopus