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Effects of different culture conditions on biological potential and metabolites production in three Penicillium isolates

2015Journal article Open access
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dc.contributor.authorReis, Filipa S.
dc.contributor.authorĆirić, Ana
dc.contributor.authorStojković, Dejan
dc.contributor.authorBarros, Lillian
dc.contributor.authorLjaljević-Grbić, Milica
dc.contributor.authorSoković, Marina
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2015-10-20T14:44:38Z
dc.date.available2015-10-20T14:44:38Z
dc.date.issued2015
dc.description.abstractThe genus Penicillium is well known for its importance in drug and food production. Certain species are produced on an industrial scale for the production of antibiotics (e.g. penicillin) or for insertion in food (e.g. cheese). In the present work, three Penicillium species, part of the natural mycobiota growing on various food products were selected– P. ochrochloron, P. funiculosum and P. verrucosum var. cyclopium. The objective of our study was to value these species from the point of view of production of bioactive metabolites. The species were obtained after inoculation and growth in Czapek and Malt media. Both mycelia and culture media were analyzed to monitor the production of different metabolites by each fungus and their release to the culture medium. The concentrations of sugars, organic acids, phenolic acids and tocopherols, were determined. Antioxidant activity of the phenolic extracts was evaluated, as also the antimicrobial activity of phenolic acids, organic acids and tocopherols extracts. Rhamnose, xylose, fructose and trehalose were found in all the mycelia and culture media; the prevailing organic acids were oxalic and fumaric acids, and protocatechuic and p-hydroxybenzoic acids were the most common phenolic acids; γ-tocopherol was the most abundant vitamin E isoform. Generally, the phenolic extracts corresponding to the mycelia samples revealed higher antioxidant activity. Concerning the antimicrobial activity there were some fluctuations, however all the studied species revealed activity against the tested strains. Therefore, the in vitro bioprocesses can be an alternative for the production of bioactive metabolites that can be used by pharmaceutical industry.pt_PT
dc.description.sponsorshipThe authors are grateful to Fundação para a Ciência e a Tecnologia (FCT, Portugal), COMPETE/QREN/EU for financial support to this work (bilateral cooperation action Portugal/Serbia 2011), to CIMO (strategic project PEst-OE/AGR/UI0690/2011), and to Serbian Ministry of Education and Science for financial support (grant number 173032). L. Barros also thanks FCT, POPH-QREN and FSE for her grant (SFRH/BPD/4609/2008).pt_PT
dc.identifier10.3109/03639045.2013.858738
dc.identifier.citationReis, Filipa S.; Ćirić, Ana; Stojković, Dejan; Barros, Lillian; Ljaljević-Grbić, Milica; Soković, Marina; Ferreira, Isabel C.F.R. (2015). Effects of different culture conditions on biological potential and metabolites production in three Penicillium isolates. Drug Development and Industrial Pharmacy. ISSN 0363-9045. 41:2, p. 253-262pt_PT
dc.identifier.doi10.3109/03639045.2013.858738
dc.identifier.issn0363-9045
dc.identifier.urihttp://hdl.handle.net/10198/12161
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationSFRH/BPD/4609/2008pt_PT
dc.relationStrategic Project - UI 690 - 2011-2012
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAntimicrobial activitypt_PT
dc.subjectAntioxidantpt_PT
dc.subjectFungi growthpt_PT
dc.subjectMetabolitespt_PT
dc.subjectPenicilliumpt_PT
dc.titleEffects of different culture conditions on biological potential and metabolites production in three Penicillium isolatespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleStrategic Project - UI 690 - 2011-2012
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FAGR%2FUI0690%2F2011/PT
oaire.citation.endPage262pt_PT
oaire.citation.startPage253pt_PT
oaire.citation.titleDrug Development and Industrial Pharmacypt_PT
oaire.citation.volume41pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameReis
person.familyNameBarros
person.familyNameFerreira
person.givenNameFilipa S.
person.givenNameLillian
person.givenNameIsabel C.F.R.
person.identifier469085
person.identifier144781
person.identifier.ciencia-id391F-AFE1-64C7
person.identifier.ciencia-id9616-35CB-D001
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0002-9159-0530
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridI-2093-2013
person.identifier.ridJ-3600-2013
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id36982144400
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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