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The role of phenolic compounds in the fight against cancer – a review

2013Journal article Open access
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dc.contributor.authorCarocho, Márcio
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2014-01-27T12:30:27Z
dc.date.available2014-01-27T12:30:27Z
dc.date.issued2013
dc.description.abstractCancer is a worldwide scourge; it’s the leading cause of death in developed countries and is increasing in developing countries. Mankind has been trying with effort to find better and cheaper treatments with fewer side effects, to reduce the incidence of the disease and its consequent mortality. For many years, phenolic compounds have been intensely studied for their antitumor, proapoptotic and antiangiogenic effects. In recent years, the usage of these compounds has increased considerably. This manuscript intends to structurally characterize the different phenolic compounds (flavonoids, hydroxycinnamates, hydroxybenzoates, coumarins, xanthones, chalcones, stilbenes, lignins and lignans) and their metabolic pathways as well as review the most important results regarding these compounds and their derivatives in cancer treatment and prevention both in tumor cell lines in vitro, in murine models in vivo and finally some results regarding human trials.por
dc.description.sponsorshipFundação para a Ciência e a Tecnologia (FCT, Portugal) and COMPETE/QREN/EU for research project PTDC/AGR-ALI/110062/2009 and to CIMO (strategic project PEst-OE/AGR/UI0690/2011).por
dc.identifier.citationCarocho, Márcio; Ferreira, Isabel C.F.R. (2013). The role of phenolic compounds in the fight against cancer – A review. Anti-Cancer Agents in Medicinal Chemistry. ISSN 1871-5206. 13:8, p. 1236-1258por
dc.identifier.issn1871-5206
dc.identifier.urihttp://hdl.handle.net/10198/9173
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherBentham Sciencepor
dc.relationPortuguese Wild Mushrooms: Chemical characterization and functional study of antiproliferative and proapoptotic properties in cancer cell lines
dc.relationStrategic Project - UI 690 - 2011-2012
dc.subjectAnimal modelspor
dc.subjectAnticancerpor
dc.subjectAntitumoralpor
dc.subjectCell linespor
dc.subjectClinical trialspor
dc.subjectPhenolic compoundspor
dc.titleThe role of phenolic compounds in the fight against cancer – a reviewpor
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitlePortuguese Wild Mushrooms: Chemical characterization and functional study of antiproliferative and proapoptotic properties in cancer cell lines
oaire.awardTitleStrategic Project - UI 690 - 2011-2012
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FAGR-ALI%2F110062%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FAGR%2FUI0690%2F2011/PT
oaire.citation.endPage1258por
oaire.citation.startPage1236por
oaire.citation.titleAnti-Cancer Agents in Medicinal Chemistrypor
oaire.citation.volume13por
oaire.fundingStream5876-PPCDTI
oaire.fundingStream6817 - DCRRNI ID
person.familyNameCarocho
person.familyNameFerreira
person.givenNameMárcio
person.givenNameIsabel C.F.R.
person.identifierawbWiiMAAAAJ&hl
person.identifier144781
person.identifier.ciencia-id5614-005B-5CF1
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0002-8978-4547
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id52463229800
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication46b39e1f-2674-4be1-a96a-c2e5792e6979
relation.isAuthorOfPublicationbd0d1537-2e03-41fb-b27a-140af9c35db8
relation.isAuthorOfPublication.latestForDiscovery46b39e1f-2674-4be1-a96a-c2e5792e6979
relation.isProjectOfPublication59db4b60-8cc2-4f07-a25a-8cfe78f2778f
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