Repository logo
 
Publication

Cytinus hypocistis (L.) L. extract effects in an animal model of papillomavirus-induced neoplasia

2023Journal article Open access
Simple item page
dc.contributor.authorMedeiros, Catarina
dc.contributor.authorSilva, Ana Rita
dc.contributor.authorFerreira, Tiago
dc.contributor.authorBarros, Lillian
dc.contributor.authorNeuparth, Maria João
dc.contributor.authorPeixoto, Francisco P.
dc.contributor.authorBastos, Margarida M.S.M.
dc.contributor.authorMedeiros, Rui
dc.contributor.authorCosta, Rui Miguel Gil
dc.contributor.authorPires, Maria João
dc.contributor.authorFaustino-Rocha, Ana
dc.contributor.authorGama, Adelina
dc.contributor.authorOliveira, Paula A.
dc.date.accessioned2024-01-30T16:44:46Z
dc.date.available2024-01-30T16:44:46Z
dc.date.issued2023
dc.description.abstractInfections with certain types of papillomavirus, such as the human papillomavirus 16 (HPV16), are associated with the development of preneoplastic lesions and cancers of the anogenital, and head and neck regions. Cytinus hypocistis (L.) L. extracts are composed of substances presenting antiproliferative, antioxidant, anti-inflammatory and antibacterial properties, which might be promising as new therapeutic compounds. This study analysed the influence of topical application of an extract obtained from C. hypocistis (CH) on K14-HPV16 and FVB/n mice to evaluate its therapeutic and toxicological properties. To achieve the study goals, 30 female mice, 33–37 weeks old, were divided into six groups (n=5/group): I (HPV+CH3.1); II (HPV+CH6.2); III (HPV+CH12.4); IV (FVB/ n+CH12.4); V (HPV+control) and VI (FVB/n+control). CH was applied topically to both ears for 28 days. After this period, all animals were sacrificed for samples collection. Skin lesions were classified histologically. Toxicological parameters included haematological and biochemical blood markers, and hepatic oxidative stress analysis. Transgenic animals showed a decrease in mean body weight regardless of the concentration of extract applied. The extract had no influence on physiological parameters, organ weight, or biochemical and oxidative stress parameters. Histology demonstrated the presence of proliferative epithelial lesions in the skin and oral mucosa of K14-HPV16 mice, with no association with the application of this extract. Overall, the application of CH extract had no influence on the skin lesions and was well tolerated by the animals in these concentrations.pt_PT
dc.description.sponsorshipThis work was supported by National Funds by Portuguese Foundation for Science and Technology (FCT), under the projects UID/AGR/04033/2020, UIDB/CVT/00772/2020, LA/P/0126/2020, UIDB/CVT/00772/2020 and LA/P/0059/2020, Base Funding - UIDB/00511/2020 of the Laboratory for Process Engineering, Environment, Biotechnology and Energy (LEPABE) funded by national funds through FCT/MCTES (PIDDAC); by the Research Centre of the Portuguese Institute of Oncology of Porto (project number PI86-CIIPOP- 66-2017), Project 2SMART (Engineered Smart materials for Smart citizens), with reference NORTE-01-0145-FEDER-000054, supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF). Thanks are due to CESAM and FCT/MCTES for the financial support to UIDP/50017/2020+UIDB/50017/2020, through national funds. This work was supported by LA/P/0045/2020 (ALiCE), UIDB/00511/2020 and UIDP/00511/2020 (LEPABE), funded by nationals funds through FCT/MCTES (PIDDAC); 2SMART (NORTE-01-0145-FEDER- 000054), supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF). The authors acknowledge the financial support by the FCT through a Doctoral Grant (2020.04789.BD, Tiago Ferreira). The authors are also grateful to FCT for financial support through national funds FCT/MCTES (PIDDAC) to CIMO (UIDB/00690/2020 and UIDP/00690/2020) and SusTEC (LA/P/0007/2020); A. R. Silva Doctoral Grant (SFRH/BD/145834/2019) and L. Barros contract through the institutional scientific employment program.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMedeiros, Catarina; Silva, Ana Rita; Ferreira, Tiago; Barros, Lillian; Neuparth, Maria João; Peixoto, Francisco P. ; Bastos, Margarida M.S.M.; Medeiros, Rui; Costa, Rui Miguel Gil; Pires, Maria João; Faustino-Rocha, Ana; Gama, Adelina; Oliveira, Paula A. (2023). Cytinus hypocistis (L.) L. extract effects in an animal model of papillomavirus-induced neoplasia. Veterinarska stanica. ISSN 0350-7149. 54:6, p. 637-653pt_PT
dc.identifier.doi10.46419/vs.54.6.9pt_PT
dc.identifier.eissn1849-1170
dc.identifier.issn0350-7149
dc.identifier.urihttp://hdl.handle.net/10198/29400
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherCroatian Veterinary Institutept_PT
dc.relationCentre for the Research and Technology of Agro-Environmental and Biological Sciences
dc.relationVeterinary and Animal Science Research Centre
dc.relationInstitute for innovation, capacity building and sustainability of agri-food production
dc.relationAssociate Laboratory for Animal and Veterinary Sciences
dc.relationLaboratory for Process Engineering, Environment, Biotechnology and Energy
dc.relationCentre for Environmental and Marine Studies
dc.relationCentre for Environmental and Marine Studies
dc.relationALICE - Associate Laboratory in Chemical Engineering
dc.relationLaboratory for Process Engineering, Environment, Biotechnology and Energy
dc.relationMountain Research Center
dc.relationMountain Research Center
dc.relationAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
dc.relationCytinus hypocistis L. L.: a case study for the development of an innovative, safe, and effective anti-photoaging cosmeceutical formulation
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAnimal modelpt_PT
dc.subjectMousept_PT
dc.subjectNatural compoundpt_PT
dc.subjectToxicologypt_PT
dc.titleCytinus hypocistis (L.) L. extract effects in an animal model of papillomavirus-induced neoplasiapt_PT
dc.title.alternativeUčinci ekstrakta Cytinus hypocistis (L.) L. u životinjskom modelu neoplazije inducirane papiloma virusompt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre for the Research and Technology of Agro-Environmental and Biological Sciences
oaire.awardTitleVeterinary and Animal Science Research Centre
oaire.awardTitleInstitute for innovation, capacity building and sustainability of agri-food production
oaire.awardTitleAssociate Laboratory for Animal and Veterinary Sciences
oaire.awardTitleLaboratory for Process Engineering, Environment, Biotechnology and Energy
oaire.awardTitleCentre for Environmental and Marine Studies
oaire.awardTitleCentre for Environmental and Marine Studies
oaire.awardTitleALICE - Associate Laboratory in Chemical Engineering
oaire.awardTitleLaboratory for Process Engineering, Environment, Biotechnology and Energy
oaire.awardTitleMountain Research Center
oaire.awardTitleMountain Research Center
oaire.awardTitleAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
oaire.awardTitleCytinus hypocistis L. L.: a case study for the development of an innovative, safe, and effective anti-photoaging cosmeceutical formulation
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04033%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00772%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0126%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0059%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00511%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50017%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50017%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0045%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00511%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0007%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBD%2F145834%2F2019/PT
oaire.citation.endPage653pt_PT
oaire.citation.issue6pt_PT
oaire.citation.startPage637pt_PT
oaire.citation.titleVeterinarska stanicapt_PT
oaire.citation.volume54pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamPOR_NORTE
person.familyNameSilva
person.familyNameBarros
person.givenNameAna Rita
person.givenNameLillian
person.identifierABD-5857-2020
person.identifier469085
person.identifier.ciencia-id0E1A-35C1-C79A
person.identifier.ciencia-id9616-35CB-D001
person.identifier.orcid0000-0001-5819-9065
person.identifier.orcid0000-0002-9050-5189
person.identifier.ridJ-3600-2013
person.identifier.scopus-author-id35236343600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication4b329c1a-e6c5-4e48-aac5-b19a6b91a279
relation.isAuthorOfPublication3af07ffe-f914-48ba-a5d5-efcf70fdce01
relation.isAuthorOfPublication.latestForDiscovery4b329c1a-e6c5-4e48-aac5-b19a6b91a279
relation.isProjectOfPublicationac4fb709-719a-450b-8c96-17592d46f5e9
relation.isProjectOfPublicationf4910f6b-8c6d-4416-bdcb-f1c208046de2
relation.isProjectOfPublication3c81413c-6a3a-453a-bb53-9e883a270537
relation.isProjectOfPublication12150547-7fbb-441e-a163-72c01b084002
relation.isProjectOfPublication3dc964d1-7e48-491e-b143-bf17354161ae
relation.isProjectOfPublicationf485cb82-0f0d-4378-bbd7-3113508539fd
relation.isProjectOfPublication38b82779-9060-417b-85cc-9780fc94d1ff
relation.isProjectOfPublicationc6751eb9-1747-4136-89dc-b13cb8c17810
relation.isProjectOfPublication38e4618f-e4d1-4899-9533-a92d33c6caa9
relation.isProjectOfPublication29718e93-4989-42bb-bcbc-4daff3870b25
relation.isProjectOfPublication0aac8939-28c2-46f4-ab6b-439dba7f9942
relation.isProjectOfPublication6255046e-bc79-4b82-8884-8b52074b4384
relation.isProjectOfPublication450b2571-2537-4f65-b153-86a34e4dc766
relation.isProjectOfPublication.latestForDiscoveryc6751eb9-1747-4136-89dc-b13cb8c17810

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Cytinus-hypocistis-L-L-extract.pdf
Size:
3.35 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.75 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

CIMO - Artigos em Revistas Indexados à WoS/Scopus