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Antimicrobials from medicinal plants: an emergent strategy to control oral biofilms

2021Journal article Open access
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dc.contributor.authorMilho, Catarina
dc.contributor.authorSilva, Jani
dc.contributor.authorGuimarães, Rafaela
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorBarros, Lillian
dc.contributor.authorAlves, Maria José
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2021-12-02T16:31:30Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2021-12-02T16:31:30Z
dc.date.issued2021
dc.description.abstractOral microbial biofilms, directly related to oral diseases, particularly caries and periodontitis, exhibit virulence factors that include acidification of the oral microenvironment and the formation of biofilm enriched with exopolysaccharides, characteristics and common mechanisms that, ultimately, justify the increase in antibiotics resistance. In this line, the search for natural products, mainly obtained through plants, and derived compounds with bioactive potential, endorse unique biological properties in the prevention of colonization, adhesion, and growth of oral bacteria. The present review aims to provide a critical and comprehensive view of the in vitro antibiofilm activity of various medicinal plants, revealing numerous species with antimicrobial properties, among which, twenty-four with biofilm inhibition/reduction percentages greater than 95%. In particular, the essential oils of Cymbopogon citratus (DC.) Stapf and Lippia alba (Mill.) seem to be the most promising in fighting microbial biofilm in Streptococcus mutans, given their high capacity to reduce biofilm at low concentrations.en_EN
dc.description.sponsorshipThe authors wish to acknowledge financial support from the project “AquaValor—Centro de Valorização e Transferência de Tecnologia da Água” (NORTE-01-0246-FEDER-000053), supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF); to the Foundation for Science and Technology (FCT, Portugal) for financial support through national funds FCT/MCTES to CIMO (UIDB/00690/2020); and L. Barros thanks the national funding by FCT, P.I., through the institutional scientific employment program-contract for her contract.
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationMilho, Catarina; Silva, Jani; Guimarães, Rafaela; Ferreira, Isabel C.F.R.; Barros, Lillian; Alves, Maria José (2021). Antimicrobials from medicinal plants: an emergent strategy to control oral biofilms. Applied Sciences. ISSN 2076-3417. 11:9, p. 1-37en_EN
dc.identifier.doi10.3390/app11094020en_EN
dc.identifier.urihttp://hdl.handle.net/10198/24419
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.relationMountain Research Center
dc.subjectAntibiofilm strategiesen_EN
dc.subjectDrug resistanceen_EN
dc.subjectMedicinal plantsen_EN
dc.subjectOral biofilmen_EN
dc.subjectOral diseasesen_EN
dc.titleAntimicrobials from medicinal plants: an emergent strategy to control oral biofilmsen_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMountain Research Center
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameFerreira
person.familyNameBarros
person.familyNameAlves
person.givenNameIsabel C.F.R.
person.givenNameLillian
person.givenNameMaria José
person.identifier144781
person.identifier469085
person.identifier.ciencia-id9418-CF95-9919
person.identifier.ciencia-id9616-35CB-D001
person.identifier.ciencia-idD618-B3A9-D312
person.identifier.orcid0000-0003-4910-4882
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0001-8506-4393
person.identifier.ridE-8500-2013
person.identifier.ridJ-3600-2013
person.identifier.ridM-6624-2016
person.identifier.scopus-author-id36868826600
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id16400584800
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
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relation.isAuthorOfPublication.latestForDiscovery3af07ffe-f914-48ba-a5d5-efcf70fdce01
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