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Virgin olive oil as a source of anti-inflammatory agents

2014Book part Open access
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dc.contributor.authorCardoso, Susana M.
dc.contributor.authorCatarino, Marcelo D.
dc.contributor.authorSemião, Marta S.
dc.contributor.authorPereira, Olívia R.
dc.date.accessioned2014-08-04T10:32:38Z
dc.date.available2014-08-04T10:32:38Z
dc.date.issued2014
dc.description.abstractVirgin olive oil (VOO) has many potential health benefits, including the amelioration of inflammatory processes. In part, this is known to occur through the modification of the endothelial function, leading to a decrease of the levels of cell-adhesion molecules (CAMs), including the inter-cellular adhesion molecule 1 (ICAM-1) and the vascular cell adhesion molecule 1 (VCAM-1). Importantly, virgin olive oil is able to inhibit the tumor necrosis factor-alpha (TNF-α), that is a key cytokine in controlling distinct types of cell functions and a particular therapeutic target for inflammatory diseases. Moreover, in vitro and in vivo assays with virgin olive oil or its main components clearly indicate a marked modulation of signaling pathways regulating the activation of pro-inflammatory mediators, including the nuclear transcriptional factor NF-κβ, the cytokines interleukin-1 (IL-1), and interleukin-6 (IL-6), and the enzymes cyclooxygenase-2 (COX-2), 5-lipoxygenase (5-LOX) and inducible nitric oxide synthase (iNOS). So far, the cellular and molecular anti-inflammatory mechanisms of virgin olive oil have been particular associated with its high amounts of phenolic compounds, as well as to its composition in mono and polyunsaturated fatty acids. Still, the available data is disperse and needs consolidation, in order to allow solid conclusions on this issue. The present chapter summarizes the epidemiological data and intervention trials focusing the effects of virgin olive oil in inflammatory processes and/or inflammatory related-diseases, as well as the main virgin olive oil constituents associated to the protection process and their underlying mechanisms of action.por
dc.identifier.citationCardoso, Susana M.; Catarino, Marcelo D.; Semião, Marta S.; Pereira, Olívia R.(2014) - Virgin olive oil as a source of anti-inflammatory agentes. In Antonella de Leonardis Virgin olive oil, production, composition, uses and benefits for man. New York : Nova Science Publishers. p.187-209. ISBN 978-1-63117-662-3por
dc.identifier.isbn978-1-63117-662-3
dc.identifier.urihttp://hdl.handle.net/10198/10017
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherNova Science Publisherspor
dc.subjectVirgin olive oilpor
dc.subjectIIflammationpor
dc.subjectAtherosclerosispor
dc.subjectBowel diseasespor
dc.subjectCancerpor
dc.titleVirgin olive oil as a source of anti-inflammatory agentspor
dc.typebook part
dspace.entity.typePublication
oaire.citation.conferencePlaceNew Yorkpor
oaire.citation.endPage209por
oaire.citation.startPage187por
oaire.citation.titleVirgin olive oil, production, composition, uses and benefits for manpor
person.familyNamePereira
person.givenNameOlívia R.
person.identifier145216
person.identifier.ciencia-idB312-AF21-D2FA
person.identifier.orcid0000-0002-6275-3134
person.identifier.ridH-1049-2014
person.identifier.scopus-author-id52264387000
rcaap.rightsopenAccesspor
rcaap.typebookPartpor
relation.isAuthorOfPublicatione8fdab9a-3ad6-47e6-b90c-7a37aabcb453
relation.isAuthorOfPublication.latestForDiscoverye8fdab9a-3ad6-47e6-b90c-7a37aabcb453

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