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Preliminary investigation on antioxidant, antibacterial and antiproliferative activities on Pleurotus eryngii var. thapsiae, as potential source of bioactive compounds

2023Conference object Open access
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dc.contributor.authorCirlincione, Fortunato
dc.contributor.authorCardoso, Rossana V.C.
dc.contributor.authorMandim, Filipa
dc.contributor.authorMolina, Adriana K.
dc.contributor.authorPires, Tânia C.S.P.
dc.contributor.authorVenturella, Giuseppe
dc.contributor.authorBarros, Lillian
dc.date.accessioned2023-11-16T16:30:58Z
dc.date.available2023-11-16T16:30:58Z
dc.date.issued2023
dc.description.abstractSince ancient times mushrooms have been appreciated as food, and in more recent years their medicinal properties have been increasingly exploited. Apart from their use as simple foods, mushrooms are being explored as functional ingredients in the development of novel foods, mushroom-based products, and food supplements. Several studies on medicinal mushrooms have highlighted their wide pharmacological activities, including antioxidant, antimicrobial, anti-inflammatory, and antitumor properties. These pharmacological effects can be attributed to the rich bioactive metabolites composition found in fungi, primarily in the mycelium and sporophores (1). The most studied molecules are phenolic compounds, proteins, fatty acids, terpenes, terpenoids, steroids, and vitamins (2). Several reports have also been conducted on polysaccharides, which are the structural components of the mushroom cell wall and exhibited a strong biological activity (3). Heteroglycans, peptidoglycans, and polysaccharide-protein complexes are polysaccharides that contribute to functional properties that mushroom are known to have, but the most abundant and well-known compounds are α- and β-glucans. Pleurotus (Fr.) P. Kumm. is one of the most widely taxonomic group and include different cultivated and economically important mushrooms. These mushrooms are widely used in human nutrition all over the world and are also recognized as medicinal mushrooms. The genus includes facultative saprotrophs or biotrophs which grow in association with plants of the Apiaceae family, the P. eryngii species complex is undoubtedly noteworthy (4). In this study, we focused on the use of P. eryngii var. thapsiae Venturella, Zervakis & Saitta, whose basidiomes grow in association with Thapsia garganica L. and have been currently reported so far only in Sicily (Italy). The basidiomes growing on two different substrates were used, the first based on wheat straw and the second based on a mixture of wheat straw and Aegilops spp., a common wheat weed. Aqueous crude extracts produced by two different techniques, conventional low-temperature, and ultrasound-assisted extraction, were used. These extracts were tested by radical scavenging activity (DPPH), thiobarbituric acid reactive substances (TBARS) formation inhibition, oxidative haemolysis inhibition assay (OxHLIA), antimicrobial (food and clinical bacteria and fungi) and antiproliferative assays on different human tumor cell lines. Preliminary results showed interesting antimicrobial activities against several Gram-positive and Gram-negative bacteria, including multi-resistant strains, as well as antifungal activities against Aspergillus brasiliensis. Regarding antiproliferative potential, very interesting results were observed against gastric (AGS), colorectal (CaCo-2), breast (MCF7), and liver (NCI-H460) cancer cell lines. Further evaluation of the biological activities and chemical characterization of polysaccharides within the extracts is in progress.pt_PT
dc.description.sponsorshipThe authors are also grateful to FCT for financial support through national funds FCT/MCTES (PIDDAC) to CIMO (UIDB/00690/2020 and UIDP/00690/2020) and SusTEC (LA/P/0007/2020). L. Barros thanks the national funding by FCT, through the institutional scientific employment program contract for her contract; and for F. Mandim PhD and A. K. Molina grant (SRFH/BD/146614/2019 and 2020.06231.BD, respectively).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCirlincione, Fortunato; Cardoso, Rossana V.C.; Mandim, Filipa; Molina, Adriana K.; Pires, Tânia C.S.P.; Venturella, Giuseppe; Barros, Lillian (2023). Preliminary investigation on antioxidant, antibacterial and antiproliferative activities on Pleurotus eryngii var. thapsiae, as potential source of bioactive compounds. In XIX Congress of European Mycologists Perugia: Book of Abstracts. Perugiapt_PT
dc.identifier.urihttp://hdl.handle.net/10198/28893
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationSRFH/BD/146614/2019pt_PT
dc.relationMountain Research Center
dc.relationMountain Research Center
dc.relationAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectPleurotus eryngii var.pt_PT
dc.titlePreliminary investigation on antioxidant, antibacterial and antiproliferative activities on Pleurotus eryngii var. thapsiae, as potential source of bioactive compoundspt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleMountain Research Center
oaire.awardTitleMountain Research Center
oaire.awardTitleAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0007%2F2020/PT
oaire.citation.conferencePlacePerugiapt_PT
oaire.citation.endPage64pt_PT
oaire.citation.startPage64pt_PT
oaire.citation.titleXIX Congress of European Mycologists Perugia: Book of Abstractspt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameCardoso
person.familyNameMandim
person.familyNameMolina
person.familyNamePires
person.familyNameBarros
person.givenNameRossana V.C.
person.givenNameFilipa
person.givenNameAdriana K.
person.givenNameTânia C.S.P.
person.givenNameLillian
person.identifier2118829
person.identifier469085
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person.identifier.ciencia-idF318-9049-EB99
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person.identifier.ciencia-id321E-2D96-00CA
person.identifier.ciencia-id9616-35CB-D001
person.identifier.orcid0000-0002-6870-0391
person.identifier.orcid0000-0002-6494-2326
person.identifier.orcid0000-0002-6234-2212
person.identifier.orcid0000-0002-3954-3833
person.identifier.orcid0000-0002-9050-5189
person.identifier.ridQ-2842-2018
person.identifier.ridJ-3600-2013
person.identifier.scopus-author-id57194701579
person.identifier.scopus-author-id57057440000
person.identifier.scopus-author-id35236343600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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