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New trends from fungi secondary metabolism in the pharmaceutical industry

2023Book part Restricted access
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dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorShiraishi, Carlos S.H.
dc.contributor.authorRibeiro, Lúcia Marisa Maia
dc.contributor.authorCarocho, Márcio
dc.contributor.authorAbreu, Rui M.V.
dc.contributor.authorCoutinho, Paula
dc.contributor.authorBarros, Lillian
dc.contributor.authorVaz, Josiana A.
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2024-01-03T10:12:41Z
dc.date.available2024-01-03T10:12:41Z
dc.date.issued2023
dc.description.abstractFungi are eukaryotic organisms that can produce a wide range of secondary metabolites with a significant impact on society. Some metabolites are exploited for their activity as antioxidant, anti-inflammatory, antitumor, and anti-microbial agents, and in the production of cancer vaccines, among other pharmaceutical applications. Since the discovery of penicillin, the pharmaceutical industry has been greatly interested in fungi as sources of natural bioactive compounds, and fungi metabolites have made an indispensable contribution to improving human and animal health throughout the last decades. Starting with the development of antibiotics, the pharmaceutical industry has increasingly turned to these compounds for a variety of applications. The increase in the number of patents registered worldwide is a strong indicator that the market realizes the great potential of fungi secondary metabolites. In general, the pharmaceutical industry trend is centered on adopting different strategies to discover new drugs, and fungi secondary metabolites are viewed as having significant potential. This chapter explores the current pharmaceutical applications of secondary metabolites found in fungi. Initially, the most recent mushroom studies and their commercial pharmaceutical and cosmeceutical applications are explored. An overview of the different classes of fungi secondary metabolites with biologically relevant activities is then presented. Recently marine fungi were found to be a rich source of secondary metabolites. Due to the recent relevancy of marine fungi, an overview of marine fungi secondary metabolites with relevant pharmaceutical-related activities is also presented. Finally, the potential of fungi metabolites as a source of natural pigments and the methodologies used to characterize and explore fungi secondary metabolites are also analyzed.pt_PT
dc.description.sponsorshipThe authors are grateful to the Foundation for Science and Technology (FCT, Portugal) for financial support through national funds FCT/MCTES to CIMO (UIDB/00690/2020). L. Barros and R. Calhelha thank the national funding by FCT through the institutional scientific employment program-contract for their contract, while M. Carocho thank FCT through the individual scientific employment program-contracts (CEECIND/00831/2018).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCalhelha, Ricardo C.; Shiraishi, Carlos Seiti Hurtado; Ribeiro, Lúcia Marisa Maia; Carocho, Márcio; Abreu, Rui M.V.; Coutinho, Paula; Barros, Lillian; Vaz, Josiana A.; Ferreira, Isabel C.F.R. (2023). New trends from fungi secondary metabolism in the pharmaceutical industry. Natural Secondary Metabolites: From Nature, Through Science, to Industry. Cham: Springer Nature. p. 823-850. ISBN 978-3-031-18586-1pt_PT
dc.identifier.doi10.1007/978-3-031-18587-8_26pt_PT
dc.identifier.isbn978-3-031-18586-1
dc.identifier.isbn978-3-031-18587-8 (eBook)
dc.identifier.urihttp://hdl.handle.net/10198/29031
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Naturept_PT
dc.relationMountain Research Center
dc.relationNot Available
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAnti-inflammatorypt_PT
dc.subjectAnti-microbialpt_PT
dc.subjectAnticancerpt_PT
dc.subjectAntioxidantpt_PT
dc.titleNew trends from fungi secondary metabolism in the pharmaceutical industrypt_PT
dc.typebook part
dspace.entity.typePublication
oaire.awardTitleMountain Research Center
oaire.awardTitleNot Available
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND 2018/CEECIND%2F00831%2F2018%2FCP1578%2FCT0001/PT
oaire.citation.endPage850pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage823pt_PT
oaire.citation.titleNatural Secondary Metabolites: From Nature, Through Science, to Industrypt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamCEEC IND 2018
person.familyNameCalhelha
person.familyNameShiraishi
person.familyNameCarocho
person.familyNameAbreu
person.familyNameBarros
person.familyNameVaz
person.familyNameFerreira
person.givenNameRicardo C.
person.givenNameCarlos S.H.
person.givenNameMárcio
person.givenNameRui M.V.
person.givenNameLillian
person.givenNameJosiana A.
person.givenNameIsabel C.F.R.
person.identifierawbWiiMAAAAJ&hl
person.identifier469085
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person.identifier.ciencia-id171B-88BA-64F5
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0002-6801-4578
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person.identifier.orcid0000-0002-8978-4547
person.identifier.orcid0000-0002-7745-8015
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0002-6989-1169
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridJ-2172-2014
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typebookPartpt_PT
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