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Infusion and decoction of wild German chamomile: bioactivity and characterization of organic acids and phenolic compounds.

2013Journal article Open access
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dc.contributor.authorGuimarães, Rafaela
dc.contributor.authorBarros, Lillian
dc.contributor.authorDueñas, Montserrat
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorCarvalho, Ana Maria
dc.contributor.authorSantos-Buelga, Celestino
dc.contributor.authorQueiroz, Maria João R.P.
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2013-07-23T16:11:09Z
dc.date.available2013-07-23T16:11:09Z
dc.date.issued2013
dc.description.abstractNatural products represent a rich source of biologically active compounds and are an example of molecular diversity, with recognized potential in drug discovery. Herein, methanol extract of Matricaria recutita L. (German chamomile) and its decoction and infusion (the most consumed preparations of this herb) were submitted to an analysis of phytochemicals and bioactivity evaluation. The antioxidant activity was determined by free radicals scavenging activity, reducing power and inhibition of lipid peroxidation; the antitumour potential was tested in human tumour cell lines (breast, lung, colon, cervical and hepatocellular carcinomas), and the hepatotoxicity was evaluated using a porcine liver primary cell culture (non-tumour cells). All the samples revealed antioxidant properties. Decoction had no antitumour activity (GI50>400 µg/mL) which could indicate that this bioactivity might be related to compounds (including phenolic compounds) that were not extracted or that were affected by the decoction procedure. Both plant methanol extract and infusion showed inhibitory activity of the growth of HCT-15 (GI50 250.24 and 298.23 µg/mL, respectively) and HeLa (GI50 259.36 and 277.67 µg/mL, respectively) cell lines, without hepatotoxicity (GI50>400 µg/mL). Infusion and decoction gave higher contents of organic acids (24.42 and 23.35 g/100 g dw). Otherwise, the plant methanol extract presented the highest amounts of phenolic acids (3.99 g/100 g dw) and flavonoids (2.59 g/100 g dw). The major compound found in all the preparations was luteolin O-acylhexoside. Overall, German chamomile contains important phytochemicals with bioactive properties (mainly antitumour potential selective to colon and cervical carcinoma cell lines) to be explored in the medicine, food, and cosmetic industries.por
dc.description.sponsorshipproject PEst-OE/AGR/UI0690/2011 for financial support to CIMO. R. Guimarães, L. Barros and R. Calhelha thanks to FCT, POPH-QREN and FSE for their grants (SFRH/BD/78307/2011, SFRH/BPD/4609/2008 and SFRH/BPD/68344/2010). The GIP-USAL is financially supported by the Consolider-Ingenio 2010 Programme (FUN-C-FOOD, CSD2007-00063). M. Dueñas thanks the Spanish “Ramón y Cajal” Programme for a contract.por
dc.identifier.citationGuimarães, Rafaela; Barros, Lillian; Dueñas, Montserrat; Calhelha, Ricardo C.; Carvalho, Ana Maria; Santos-Buelga, Celestino; Queiroz, Maria João R.P.; Ferreira, Isabel C.F.R. (2013). Infusion and decoction of wild German chamomile: bioactivity and characterization of organic acids and phenolic compounds. Food Chemistry. ISSN 0308-8146. 136:2, p. 947-954por
dc.identifier.doi10.1016/j.foodchem.2012.09.007
dc.identifier.issn0308-8146
dc.identifier.urihttp://hdl.handle.net/10198/8533
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevierpor
dc.relationFRH/BD/78307/2011
dc.relationSFRH/BPD/4609/2008
dc.relationNEW ANTITUMOR AND/OR ANTI-ANGIOGENIC HETEROCYCLIC COMPOUNDS: SYNTHESIS, MOLECULAR MODELLING AND INHIBITION ENZYMATIC ASSAYS USING TYROSINE KINASE MEMBRANE GROWTH FACTOR RECEPTORS
dc.subjectMatricaria recutitapor
dc.subjectGerman chamomilepor
dc.subjectAntioxidant activitypor
dc.subjectAntitumour potentialpor
dc.subjectOrganic acidspor
dc.subjectPhenolic compoundspor
dc.titleInfusion and decoction of wild German chamomile: bioactivity and characterization of organic acids and phenolic compounds.por
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleNEW ANTITUMOR AND/OR ANTI-ANGIOGENIC HETEROCYCLIC COMPOUNDS: SYNTHESIS, MOLECULAR MODELLING AND INHIBITION ENZYMATIC ASSAYS USING TYROSINE KINASE MEMBRANE GROWTH FACTOR RECEPTORS
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/FARH/SFRH%2FBPD%2F68344%2F2010/PT
oaire.citation.endPage954por
oaire.citation.startPage947por
oaire.citation.titleFood Chemistrypor
oaire.citation.volume136por
oaire.fundingStreamFARH
person.familyNameBarros
person.familyNameCalhelha
person.familyNameCarvalho
person.familyNameFerreira
person.givenNameLillian
person.givenNameRicardo C.
person.givenNameAna Maria
person.givenNameIsabel C.F.R.
person.identifier469085
person.identifierID G-7399-2011
person.identifier144781
person.identifier.ciencia-id9616-35CB-D001
person.identifier.ciencia-idF313-E3CE-554E
person.identifier.ciencia-idD31A-35AF-E2A9
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0001-5508-5935
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridJ-3600-2013
person.identifier.ridJ-2172-2014
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id20336503900
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspor
rcaap.typearticlepor
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