Repository logo
 
Publication

Cytotoxicity of Coprinopsis atramentaria extract, organic acids and their synthesized methylated and glucuronate derivatives

2014Journal article Open access
Simple item page
dc.contributor.authorHeleno, Sandrina A.
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorEsteves, Ana P.
dc.contributor.authorMartins, Anabela
dc.contributor.authorQueiroz, Maria João R.P.
dc.date.accessioned2014-05-13T10:25:19Z
dc.date.available2014-05-13T10:25:19Z
dc.date.issued2014
dc.description.abstractCoprinopsis atramentaria is a wild edible mushroom whose methanolic extract revealed a marked antioxidant activity; p-hydroxybenzoic (HA), p-coumaric (CoA) and cinnamic (CA) acids were identified in the extract. In the present work, the cytotoxicity of C. atramentaria extract, previously identified organic acids and their synthesized derivatives (methylated compounds and protected glucuronides) was evaluated. Among all the tested cell lines (MCF-7—breast adenocarcinoma, NCI-H460—non-small cell lung carcinoma, HCT15—colon carcinoma, HeLa—cervical carcinoma and HepG2—hepatocellular carcinoma), the extract presented good activity for the first three cell lines mentioned; in most of the cases methylated and glucuronide derivatives showed a higher activity than the corresponding parental compounds. The substitution of the carboxylic group (in parental organic acids) for an ester (in methylated derivatives) increased the cytotoxicity for tumor cell lines. Acetylated glucuronide derivatives showed higher cytotoxicity when compared with the corresponding parental acids.por
dc.identifier.citationHeleno, Sandrina A.; Ferreira, Isabel C.F.R.; Calhelha, Ricardo C.; Esteves, Ana Paula; Martins, Anabela; Queiroz, Maria-João R.P. (2014). Cytotoxicity of Coprinopsis atramentaria extract, organic acids and their synthesized methylated and glucuronate derivatives. Food Research International. ISSN 0963-9969. 55, p. 170-175por
dc.identifier.doi10.1016/j.foodres.2013.11.012
dc.identifier.isbn0963-9969
dc.identifier.urihttp://hdl.handle.net/10198/9501
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevierpor
dc.relationPortuguese Wild Mushrooms: Chemical characterization and functional study of antiproliferative and proapoptotic properties in cancer cell lines
dc.relationStrategic Project - UI 686 - 2011-2012
dc.relationStrategic Project - UI 690 - 2011-2012
dc.relationIMPORTANT HUMAN METABOLITES OF PHENOLIC ACIDS FROM DIET WITH WILD EDIBLE MUSHROOMS: CHEMICAL SYNTHESIS AND STUDIES OF THEIR ANTIOXIDANT AND ANTITUMOR PROPERTIES
dc.subjectCoprinopsis atramentariapor
dc.subjectOrganic acidspor
dc.subjectAcetylated glucuronidespor
dc.subjectMethylated derivativespor
dc.subjectChemical synthesispor
dc.subjectCytotoxicitypor
dc.titleCytotoxicity of Coprinopsis atramentaria extract, organic acids and their synthesized methylated and glucuronate derivativespor
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitlePortuguese Wild Mushrooms: Chemical characterization and functional study of antiproliferative and proapoptotic properties in cancer cell lines
oaire.awardTitleStrategic Project - UI 686 - 2011-2012
oaire.awardTitleStrategic Project - UI 690 - 2011-2012
oaire.awardTitleIMPORTANT HUMAN METABOLITES OF PHENOLIC ACIDS FROM DIET WITH WILD EDIBLE MUSHROOMS: CHEMICAL SYNTHESIS AND STUDIES OF THEIR ANTIOXIDANT AND ANTITUMOR PROPERTIES
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FAGR-ALI%2F110062%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6820 - DCRRNI ID/PEst-C%2FQUI%2FUI0686%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FAGR%2FUI0690%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F70304%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F68344%2F2010/PT
oaire.citation.endPage175por
oaire.citation.startPage170por
oaire.citation.titleFood Research Internationalpor
oaire.citation.volume55por
oaire.fundingStream5876-PPCDTI
oaire.fundingStream6820 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamSFRH
person.familyNameHeleno
person.familyNameFerreira
person.familyNameCalhelha
person.familyNameMartins
person.givenNameSandrina A.
person.givenNameIsabel C.F.R.
person.givenNameRicardo C.
person.givenNameAnabela
person.identifier144781
person.identifier.ciencia-id8B18-3095-6FC9
person.identifier.ciencia-id9418-CF95-9919
person.identifier.ciencia-idF313-E3CE-554E
person.identifier.ciencia-id7B18-A810-6B93
person.identifier.orcid0000-0001-7224-1098
person.identifier.orcid0000-0003-4910-4882
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0001-6218-4413
person.identifier.ridL-5951-2014
person.identifier.ridE-8500-2013
person.identifier.ridJ-2172-2014
person.identifier.ridG-5488-2013
person.identifier.scopus-author-id30067731800
person.identifier.scopus-author-id36868826600
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id7203013518
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublicatione89b5bf5-d315-49b6-871e-fa8eb6030676
relation.isAuthorOfPublicationbd0d1537-2e03-41fb-b27a-140af9c35db8
relation.isAuthorOfPublication2d5d1a41-7561-4a01-871c-b4c97da35053
relation.isAuthorOfPublication383370dd-10e5-40e6-9a15-f2201fe95581
relation.isAuthorOfPublication.latestForDiscoverybd0d1537-2e03-41fb-b27a-140af9c35db8
relation.isProjectOfPublication59db4b60-8cc2-4f07-a25a-8cfe78f2778f
relation.isProjectOfPublicationec5d1315-a47f-4629-907c-e4737edfafac
relation.isProjectOfPublicationc59f09d4-9931-4f2e-babb-ef8bed998be7
relation.isProjectOfPublication81c2dd9c-140a-47d1-b37c-514cb80df3c9
relation.isProjectOfPublication11192b59-0b2d-42b9-bf36-31bc50f8bccc
relation.isProjectOfPublication.latestForDiscoveryc59f09d4-9931-4f2e-babb-ef8bed998be7

Files

Original bundle
Now showing 1 - 2 of 2
No Thumbnail Available
Name:
Antitumor_FRI_Revised.pdf
Size:
569.8 KB
Format:
Adobe Portable Document Format
Download
No Thumbnail Available
Name:
1-s2.0-S096399691300611X-main.pdf
Size:
486.36 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.73 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

CIMO - Artigos em Revistas Indexados à WoS/Scopus