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Evaluation of antioxidant and anticancer activity of mono- and polyfloral moroccan bee pollen by characterizing phenolic and volatile compounds

2023Journal article Open access
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dc.contributor.authorAylanc, Volkan
dc.contributor.authorLarbi, Samar
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorBarros, Lillian
dc.contributor.authorRezouga, Feriel
dc.contributor.authorRodriguez-Flores, Maria Shantal
dc.contributor.authorSeijo-Coello, M. Carmen
dc.contributor.authorEl Ghouizi, Asmae
dc.contributor.authorLyoussi, Badiâa
dc.contributor.authorFalcão, Soraia
dc.contributor.authorVilas-Boas, Miguel
dc.date.accessioned2011-06-02T11:52:20Z
dc.date.available2011-06-02T11:52:20Z
dc.date.issued2023
dc.description.abstractBee pollen is frequently characterized as a natural source of bioactive components, such as phenolic compounds, which are responsible for its pharmaceutical potential and nutritional properties. In this study, we evaluated the bioactive compound contents of mono- and polyfloral bee pollen samples using spectroscopic and chromatographic methods and established links with their antioxidant and antitumor activity. The findings demonstrated that the botanical origin of bee pollen has a remarkable impact on its phenolic (3-17 mg GAE/g) and flavonoid (0.5-3.2 mg QE/g) contents. Liquid chromatography-mass spectrometry analysis revealed the presence of 35 phenolic and 13 phenylamide compounds in bee pollen, while gas chromatography-mass spectrometry showed its richness in volatiles, such as hydrocarbons, fatty acids, alcohols, ketones, etc. The concentration of bioactive compounds in each sample resulted in a substantial distinction in their antioxidant activity, DPPH (EC50: 0.3-0.7 mg/mL), ABTS (0.8-1.3 mM Trolox/mg), and reducing power (0.03-0.05 mg GAE/g), with the most bioactive pollens being the monofloral samples from Olea europaea and Ononis spinosa. Complementarily, some samples revealed a moderate effect on cervical carcinoma (GI(50): 495 mu g/mL) and breast adenocarcinoma (GI(50): 734 mu g/mL) cell lines. This may be associated with compounds such as quercetin-O-diglucoside and kaempferol-3-O-rhamnoside, which are present in pollens from Olea europaea and Coriandrum, respectively. Overall, the results highlighted the potentiality of bee pollen to serve health-promoting formulations in the future.por
dc.identifier.citationAylanc, Volkan; Larbi, Samar; Calhelha, Ricardo C.; Barros, Lillian; Rezouga, Feriel; Rodriguez-Flores, Maria Shantal; Seijo-Coello, M. Carmen; El Ghouizi, Asmae; Lyoussi, Badiâa; Falcão, Soraia; Vilas-Boas, Miguel. (2023). Evaluation of antioxidant and anticancer activity of mono- and polyfloral moroccan bee pollen by characterizing phenolic and volatile compounds. Molecules. eISSN 1420-3049. 28:2, p. 1-20por
dc.identifier.doi10.3390/molecules28020835
dc.identifier.eissn1420-3049
dc.identifier.urihttp://hdl.handle.net/10198/4913
dc.language.isoengpor
dc.publisherMDPIpor
dc.subjectAntiradical capacity
dc.subjectAntitumor activity
dc.subjectBee products
dc.subjectBioactive compounds
dc.subjectPhenolic compounds
dc.subjectPhenylamides
dc.titleEvaluation of antioxidant and anticancer activity of mono- and polyfloral moroccan bee pollen by characterizing phenolic and volatile compoundspor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleMoleculespor
person.familyNameAylanc
person.familyNameCalhelha
person.familyNameBarros
person.familyNameFalcão
person.familyNameVilas-Boas
person.givenNameVolkan
person.givenNameRicardo C.
person.givenNameLillian
person.givenNameSoraia
person.givenNameMiguel
person.identifier469085
person.identifier711432
person.identifier1693134
person.identifier.ciencia-idFB10-056C-9A56
person.identifier.ciencia-idF313-E3CE-554E
person.identifier.ciencia-id9616-35CB-D001
person.identifier.ciencia-idD41A-6BED-4CBB
person.identifier.ciencia-idA918-C6FF-81A4
person.identifier.orcid0000-0003-4060-766X
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0003-3735-6951
person.identifier.orcid0000-0002-8665-5280
person.identifier.ridJ-2172-2014
person.identifier.ridJ-3600-2013
person.identifier.ridI-5949-2013
person.identifier.scopus-author-id57189037561
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id14832459200
person.identifier.scopus-author-id6602648497
rcaap.rightsopenAccesspor
rcaap.typearticle
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