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Preparative separation of nadolol racemates using reversed-phase liquid chromatography

2016Conference object Open access
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dc.contributor.authorArafah, Rami
dc.contributor.authorRibeiro, António E.
dc.contributor.authorRodrigues, Alírio
dc.contributor.authorPais, Luís S.
dc.date.accessioned2018-03-19T15:21:01Z
dc.date.available2018-03-19T15:21:01Z
dc.date.issued2016
dc.description.abstractNadolol is a nonselective beta-adrenergic receptor antagonist ( -blocker) pharmaceutical drug, widely used in the treatment of cardiovascular diseases, such as hypertension, ischemic heart disease (angina pectoris), congestive heart failure, and certain arrhythmias. Its chemical structure has three stereogenic centers which allows for eight possible stereoisomers. However, the two hydroxyl substituents on the cyclohexane ring are fixed in the cis-configuration, which precludes four stereoisomers; in fact, two pairs of enantiomers. Nadolol is presently marketed as an equal mixture of the four stereoisomers, designated as the diastereoisomers, There are still few published works concerning the separation of nadolol stereoisomers. Most of these works refer the resolution at analytical scale and few refer the separation at preparative scale using the simulated moving bed (SMB) technology [2-4]. This technology is generally based on the use of chiral adsorbents which must have enough recognition for all the chiral species.pt_PT
dc.description.sponsorshipThis work was financially supported by Project POCI-01-0145-FEDER-006984 - Associate Laboratory LSRE-LCM - funded by FEDER funds through COMPETE2020 - Programa Operacional Competitividade e Internacionalização (POCI) and by national funds through FCT - Fundação para a Ciência e a Tecnologia. This work was also cofinanced by QREN, ON2 and FEDER through Project NORTE-07-0162-FEDER-000050.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationArafah, Rami; Ribeiro, António E.; Rodrigues, A.E.; Pais, L.S. (2016). Preparative separation of nadolol racemates using reversed-phase liquid chromatography. In XXII Encontro Luso-Galego de Química: livro de resumos. Bragança: Instituto Politécnico. ISBN 978-989-8124-17-3pt_PT
dc.identifier.isbn978-989-8124-17-3
dc.identifier.urihttp://hdl.handle.net/10198/16379
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectnadolol racematespt_PT
dc.subjectreversed-phase liquid chromatographypt_PT
dc.subjectsimulated moving bed (SMB) technologypt_PT
dc.titlePreparative separation of nadolol racemates using reversed-phase liquid chromatographypt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceBragança, Portugalpt_PT
oaire.citation.startPage265pt_PT
oaire.citation.titleXXII Encontro Luso-Galego de Químicapt_PT
person.familyNameArafah
person.familyNameRibeiro
person.familyNamePais
person.givenNameRami
person.givenNameAntónio E.
person.givenNameLuís S.
person.identifier.ciencia-idAB16-ECBF-B886
person.identifier.ciencia-id3211-D5B0-870D
person.identifier.ciencia-id421E-0CCD-A84F
person.identifier.orcid0000-0002-7743-4988
person.identifier.orcid0000-0003-4569-7887
person.identifier.orcid0000-0002-3000-2862
person.identifier.scopus-author-id57151342900
person.identifier.scopus-author-id23390701300
person.identifier.scopus-author-id6603930478
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublication3cd4864a-8aa6-46a2-9415-767a7551ee62
relation.isAuthorOfPublication52666376-f100-4407-87ef-dc5df3613761
relation.isAuthorOfPublicationc6d25534-8487-45b1-90af-d350f4e3ac55
relation.isAuthorOfPublication.latestForDiscovery3cd4864a-8aa6-46a2-9415-767a7551ee62

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