Publication
New cytotoxic neolignans from the cobalt crust fungus
| dc.contributor.author | García, Pablo A. | |
| dc.contributor.author | Maisterra Udi, Maitane | |
| dc.contributor.author | Castro, María Ángeles | |
| dc.contributor.author | Muñoz-Centeno, Luz M. | |
| dc.contributor.author | Calhelha, Ricardo C. | |
| dc.contributor.author | Ferreira, Isabel C.F.R. | |
| dc.date.accessioned | 2018-02-21T12:15:26Z | |
| dc.date.available | 2018-02-21T12:15:26Z | |
| dc.date.issued | 2017 | |
| dc.description.abstract | Terana coerulea (Phanerochaetaceae family) is known as the cobalt crust fungus and it is used for its antibiotic properties at the Irati’s Forest (Navarra, Spain). Previous mycochemical investigations reported the isolation of corticins A-C,[1] p-terphenyl neolignans related to the antitumoural telephoric acid.[2] In this job, from powdered dry fungi, six extracts of increasing polarity were obtained and tested for cytotoxicity against four human tumour cell lines and one non-tumour primary cell culture with the sulforhodamine B assay. From the most cytotoxic one, the EtOAc extract, we isolated and identified three p-terphenyl neolignans. One of them was previously described as corticin A by Briggs et al.,[1] whose earlier structure has been revised in this work using one- and two-dimensional NMR, HRMS, positive and negative MS/MS and its peracetyl derivative in comparison with 4’’-deoxy and 4,5-dimethoxy candidusines A.[3] The other two neolignans are new natural products, named corticins D and E. These neolignans were less cytotoxic than the EtOAc extract itself, maybe due to an aerial oxidation and degradation produced when these neolignans, with catechol moieties, are definitively purified. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | García, Pablo A.; Maisterra Udi, Maitane; Castro, María Ángeles; Muñoz-Centeno, Luz M.; Calhelha, Ricardo; Ferreira, Isabel C.F.R. (2017). New cytotoxic neolignans from the cobalt crust fungus. In XXXVI Reunión Bienal de la Real Sociedad Española de Química. Barcelona | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10198/15880 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
| dc.subject | Terana coerulea | pt_PT |
| dc.subject | Neolignans | pt_PT |
| dc.subject | Terphenyls | pt_PT |
| dc.subject | Corticin | pt_PT |
| dc.subject | Cytotoxicity | pt_PT |
| dc.title | New cytotoxic neolignans from the cobalt crust fungus | pt_PT |
| dc.type | conference object | |
| dspace.entity.type | Publication | |
| oaire.citation.conferencePlace | Barcelona | pt_PT |
| oaire.citation.title | XXXVI Reunión Bienal de la Real Sociedad Española de Química | pt_PT |
| person.familyName | Calhelha | |
| person.familyName | Ferreira | |
| person.givenName | Ricardo C. | |
| person.givenName | Isabel C.F.R. | |
| person.identifier | 144781 | |
| person.identifier.ciencia-id | F313-E3CE-554E | |
| person.identifier.ciencia-id | 9418-CF95-9919 | |
| person.identifier.orcid | 0000-0002-6801-4578 | |
| person.identifier.orcid | 0000-0003-4910-4882 | |
| person.identifier.rid | J-2172-2014 | |
| person.identifier.rid | E-8500-2013 | |
| person.identifier.scopus-author-id | 6507978333 | |
| person.identifier.scopus-author-id | 36868826600 | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | conferenceObject | pt_PT |
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| relation.isAuthorOfPublication | bd0d1537-2e03-41fb-b27a-140af9c35db8 | |
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