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Perennial spotted rockrose as a source of Ellagitannins with therapeutic interest: influence of drying and extraction conditions

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dc.contributor.authorPinela, José
dc.contributor.authorBarreira, João C.M.
dc.contributor.authorBarros, Lillian
dc.contributor.authorOliveira, Beatriz
dc.contributor.authorCarvalho, Ana Maria
dc.contributor.authorSantos-Buelga, Celestino
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2015-11-16T16:22:44Z
dc.date.available2015-11-16T16:22:44Z
dc.date.issued2015
dc.description.abstractThe ellagitannins are a diverse class of hydrolysable tannins, a type of polyphenols present in some fruits, medicinal plants, nuts and seeds. They are complex derivatives of ellagic acid characterized by one or more hexahydroxydiphenoyl moieties esterified to a sugar, usually glucose [1]. These compounds play an important role in human nutrition and are endowed with numerous biological properties, including antioxidant, anti-inflammatory, anticancer, antiatherosclerotic, antihepatotoxic, antibacterial and anti-HIV replication activities [1-3], being therefore interesting molecules for medicinal and therapeutic applications. A previous work of our research team highlighted the perennial spotted rockrose (Tuberaria lignosa (Sweet) Samp.) as a rich source of ellagitannins, namely punicalagin [2]. In this study, the influence of drying and extraction conditions on the ellagitannins content from perennial spotted rockrose flowering aerial parts was evaluated. Wild specimens were gathered in the Northeast region of Portugal and then freeze-dried immediately after gathering or shade-dried in a dark and dry place at room temperature for 30 days. Subsequently, dried samples were extracted adding them to boiling water and left to stand at room temperature for 5 min, or boiling them for 5 min plus 5 min at room temperature. The ellagitannins analysis was performed by HPLC-DAD-ESI/MS. The effects of drying and extraction conditions were evaluated by analysis of variance (ANOVA) using the General Linear Model procedure. The most abundant ellagitannins were punicalagin isomers and punicalagin gallate isomers, being the highest levels detected in freeze-dried samples. Additionally, higher amounts of these compounds were achieved with longer extraction time (5 min + 5 min), in both shade- and freeze-dried samples. Thus, from the obtained results, it might be concluded that freeze-drying and longer extraction time are the preferable conditions to obtain high levels of ellagitannins with therapeutic interest from perennial spotted rockrose samples.pt_PT
dc.identifier.citationPinela, José; Barreira, João C.M.; Barros, Lillian; Oliveira, M.B.P.P.; Carvalho, Ana Maria; Santos-Buelga, Celestino; Ferreira, Isabel C.F.R. (2015). Perennial spotted rockrose as a source of Ellagitannins with therapeutic interest: influence of drying and extraction conditions. In 2nd Symposium on Medicinal Chemistry of University of Minhopt_PT
dc.identifier.urihttp://hdl.handle.net/10198/12341
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationPRODER 53514 - AROMAPpt_PT
dc.relationBIOACTIVE PROPERTIES & CYTOPROTECTIVE POTENTIAL OF NATURAL EXTRACTS/INDIVIDUAL COMPOUNDS: APPLICATION OF SINGLE CELL GEL ELECTROPHORESIS AND OTHER BIOCHEMICAL, CHEMICAL AND ELECTROCHEMICAL ASSAYS
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titlePerennial spotted rockrose as a source of Ellagitannins with therapeutic interest: influence of drying and extraction conditionspt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleBIOACTIVE PROPERTIES & CYTOPROTECTIVE POTENTIAL OF NATURAL EXTRACTS/INDIVIDUAL COMPOUNDS: APPLICATION OF SINGLE CELL GEL ELECTROPHORESIS AND OTHER BIOCHEMICAL, CHEMICAL AND ELECTROCHEMICAL ASSAYS
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/PEst-OE%2FAGR%2FUI0690%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/Incentivo%2FEQB%2FLA0006%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F72802%2F2010/PT
oaire.citation.title2nd Symposium on Medicinal Chemistry of University of Minhopt_PT
oaire.fundingStream5876
oaire.fundingStream3599-PPCDT
person.familyNamePinela
person.familyNameBarreira
person.familyNameBarros
person.familyNameCarvalho
person.familyNameFerreira
person.givenNameJosé
person.givenNameJoão C.M.
person.givenNameLillian
person.givenNameAna Maria
person.givenNameIsabel C.F.R.
person.identifier469085
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person.identifier.orcid0000-0001-7523-1637
person.identifier.orcid0000-0003-1233-0990
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0001-5508-5935
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridB-4466-2014
person.identifier.ridD-8269-2013
person.identifier.ridJ-3600-2013
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person.identifier.scopus-author-id54392272800
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person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id20336503900
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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