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Tailloring deep eutectic solvents for the extraction of valuable compounds from natural sources using choline chloride and carboxylic acids mixtures: optimization of the extraction of phenolic compounds from Juglans regia L. leaves

2017Conference object Open access
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dc.contributor.authorVieira, Vanessa
dc.contributor.authorPrieto Lage, Miguel A.
dc.contributor.authorBarros, Lillian
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorFerreira, Olga
dc.contributor.authorCoutinho, João A.P.
dc.date.accessioned2018-03-05T11:23:29Z
dc.date.available2018-03-05T11:23:29Z
dc.date.issued2017
dc.description.abstractPhenolic compounds are a wide group of plant secondary metabolites with increasing interest due to their antioxidant ability and marked effects on oxidative processes related to several chronic diseases. Nowadays, they find applications in pharmaceutical products, functional foods and natural-based cosmetics. Therefore, the extraction and identification of these valuable compounds from different plants have become a major research area. Nevertheless, conventional solid-liquid extraction of phenolics usually involves the use of flammable, toxic and volatile organic solvents. Deep eutectic solvents (DES) are gaining much interest as alternative solvents to extract valuable compounds from natural matrices. DES can be considered “designer solvents” due to the possibility of combining different HBA (hydrogen bond acceptor) and HBD (hydrogen bond donor) to obtain solvents with specific properties to the target application. In this study, DES composed of choline chloride (CC) and different groups of organic acids were prepared, in order to extract phenolic compounds from leaves of Juglans regia L. (walnut leaves). The initial screening involved monocarboxylic (acetic, propionic, butyric, valeric, lactic and glycolic acids), dicarboxylic (malonic, glutaric and malic acids), tricarboxylic (citric) and aromatic acids (phenylacetic acid, 3-phenylpropanoic acid). The initial extraction conditions were: 50 ºC, 60 min extraction time and 20% water content. The main phenolic compounds (neochlorogenic acid, quercetin 3-O-glucoside and quercetin O-pentoside) were quantified by high performance liquid chromatography coupled to a diode de array detector (HPLC-DAD at 280 and 370 nm). Higher extraction yields were obtained using CC:butyric acid and CC:3-phenylpropanoic acid. For these systems, the stoichiometric ratio of HBA and HBD as well as the water content in the DES solutions were further evaluated. Better results were obtained using DES compared to the conventional water + ethanol mixed solvent. The present work contributes to the valorization of walnut leaves extracts using alternative solvents that could be tailored for potential applications in the food and pharmaceutical areas.pt_PT
dc.description.sponsorshipThe authors thank the Foundation for Science and Technology (FCT, Portugal) and FEDER under Programme PT2020 for financial support to CIMO (UID/AGR/00690/2013), L. Barros (SFRH/BPD/107855/2015) and V. Vieira (SFRH/BD/108487/2015) grants. To POCI-01-0145-FEDER-006984 (LA LSRE-LCM), funded by ERDF, through POCI-COMPETE2020 and FCT. To Xunta de Galicia for financial support for the post-doctoral researcher of M.A. Prieto.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationVieira, Vanessa; Prieto, Miguel; Barros, Lillian; Ferreira, Isabel C.F.R.; Ferreira, Olga; Coutinho, João A.P. (2017). Tailloring deep eutectic solvents for the extraction of valuable compounds from natural sources using choline chloride and carboxylic acids mixtures: optimization of the extraction of phenolic compounds from Juglans regia L. Leaves. In São Paulo School of advanced sciences on reverse engineering of processed food: book of abstracts. São Paulopt_PT
dc.identifier.urihttp://hdl.handle.net/10198/16166
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationProviding industry and consumers with new alternative sources of natural additives from plant origin in the classes of preservatives and colouring agents: extraction, purification, stabilization and product development
dc.relationUsing natural deep eutectic solvents for the extraction of bioactive compounds from plant material: valorizing walnut residues through the development of bio-based semi-solid formulas for topical use
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleTailloring deep eutectic solvents for the extraction of valuable compounds from natural sources using choline chloride and carboxylic acids mixtures: optimization of the extraction of phenolic compounds from Juglans regia L. leavespt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleProviding industry and consumers with new alternative sources of natural additives from plant origin in the classes of preservatives and colouring agents: extraction, purification, stabilization and product development
oaire.awardTitleUsing natural deep eutectic solvents for the extraction of bioactive compounds from plant material: valorizing walnut residues through the development of bio-based semi-solid formulas for topical use
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FAGR%2F00690%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F107855%2F2015/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F108487%2F2015/PT
oaire.citation.conferencePlaceSão Paulo, Brasilpt_PT
oaire.citation.titleSão Paulo School of advanced sciences on reverse engineering of processed foodpt_PT
oaire.fundingStream5876
person.familyNamePrieto Lage
person.familyNameBarros
person.familyNameFerreira
person.familyNameFerreira
person.givenNameMiguel A.
person.givenNameLillian
person.givenNameIsabel C.F.R.
person.givenNameOlga
person.identifier107688
person.identifier469085
person.identifier144781
person.identifier.ciencia-id221E-1E00-AB74
person.identifier.ciencia-id9616-35CB-D001
person.identifier.ciencia-id9418-CF95-9919
person.identifier.ciencia-id9F1D-C75A-4A54
person.identifier.orcid0000-0002-3513-0054
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0003-4910-4882
person.identifier.orcid0000-0001-8414-3479
person.identifier.ridG-4516-2011
person.identifier.ridJ-3600-2013
person.identifier.ridE-8500-2013
person.identifier.ridM-4567-2013
person.identifier.scopus-author-id35937495700
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id36868826600
person.identifier.scopus-author-id57203083219
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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