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Juglans regia L. leaves as a source of bioactive phenolic compounds

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dc.contributor.authorSantos, André
dc.contributor.authorBarros, Lillian
dc.contributor.authorDueñas, Montserrat
dc.contributor.authorCarvalho, Ana Maria
dc.contributor.authorSantos-Buelga, Celestino
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2013-09-09T13:55:23Z
dc.date.available2013-09-09T13:55:23Z
dc.date.issued2013
dc.description.abstractWalnut (Juglans regia L.) leaves are considered a source of healthcare compounds, and have been widely used in traditional medicine for treatment of skin inflammations, hyperhidrosis and ulcers and for its antidiarrheic, anti-helmintic, antiseptic and astringent properties [1]. Furthermore, they have been reported as a source of phenolic compounds [2,3].The beneficial effects derived from those compounds with interesting properties, such as anticarcinogenic, antimutagenic and cardioprotective activities, have been attributed to their antioxidant activity [3]. In the present study, the phenolic composition of walnut leaves was determined and compared with previous reports. The analysis was carried out by reversed-phase high performance liquid chromatography coupled to diode array detection and mass spectrometry with electron spray ionization (HPLC-DAD-ESI/MS),after extraction with methanol:water (80:20 v/v). Twenty five compounds were identified and quantified:seven phenolic acid derivatives (caffeicacid and p-coumaric acid derivatives), two dimers and one trimer ofprocyanidins, tenflavonols (quercetin, myricetin and kaempferol derivatives), and fivetaxifolin O-pentosides. 3-0- Caffeoylquinic acids and a quercetinO-pentosidewere the most abundant phenolic compounds in the studied sample. This study provides a more complete characterization of phenolic compounds of walnut leaves, as previous reports only described eight[2] and ten [3] compounds.As far as we know, this is the first time that the presence of procyanidins and taxifolinderivatives was reported in walnut leaves. Moreover, it highlights the use of the mentioned species as a source of bioactive compounds.por
dc.identifier.citationSantos, André; Barros, Lillian; Dueñas, Montserrat; Carvalho, Ana Maria; Santos-Buelga, Celestino; Ferreira, Isabel C.F.R. (2013). Juglans regia L. leaves as a source of bioactive phenolic compounds. In 1st Symposium on Medicinal Chemistry. Bragapor
dc.identifier.urihttp://hdl.handle.net/10198/8679
dc.language.isoengpor
dc.peerreviewedyespor
dc.relationSFRH/BPD/4609/2008
dc.relationStrategic Project - UI 690 - 2011-2012
dc.titleJuglans regia L. leaves as a source of bioactive phenolic compoundspor
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleStrategic Project - UI 690 - 2011-2012
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FAGR%2FUI0690%2F2011/PT
oaire.citation.conferencePlaceBraga, Portugalpor
oaire.citation.title1st Symposium on Medicinal Chemistry of University of Minhopor
oaire.fundingStream6817 - DCRRNI ID
person.familyNameBarros
person.familyNameCarvalho
person.familyNameFerreira
person.givenNameLillian
person.givenNameAna Maria
person.givenNameIsabel C.F.R.
person.identifier469085
person.identifierID G-7399-2011
person.identifier144781
person.identifier.ciencia-id9616-35CB-D001
person.identifier.ciencia-idD31A-35AF-E2A9
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0001-5508-5935
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridJ-3600-2013
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id20336503900
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspor
rcaap.typeconferenceObjectpor
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