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Bioactivity of different enriched phenolic extracts of wild fruits from Northeastern Portugal: a comparative study

2014Journal article Open access
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dc.contributor.authorGuimarães, Rafaela
dc.contributor.authorBarros, Lillian
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorCarvalho, Ana Maria
dc.contributor.authorQueiroz, Maria João R.P.
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2014-08-13T16:44:29Z
dc.date.available2014-08-13T16:44:29Z
dc.date.issued2014
dc.description.abstractArbutus unedo, Prunus spinosa, Rosa micrantha and Rosa canina are good sources of phenolic compounds, including anthocyanins. These compounds have potent antioxidant properties, which have been related to anticancer activity. Herein, the in vitro antioxidant and antitumor properties of enriched phenolic extracts (non-anthocyanin phenolic compounds enriched extract- PE and anthocyanins enriched extract- AE) of the mentioned wild fruits were evaluated and compared. PE gave higher bioactive properties than the corresponding AE. It was observed a high capacity of A. unedo phenolic extract to inhibit lipid peroxidation in animal brain homogenates (EC50 = 7.21 µg/mL), as also a high antitumor potential against NCI-H460 human cell line (non-small lung cancer; GI50 = 37.68 µg/mL), which could be related to the presence of galloyl derivatives (exclusively found in this species). The bioactivity of the studied wild fruits proved to be more related to the phenolic compounds profile than to the amounts present in each extract, and could be considered in the design of new formulations of dietary supplements or functional foods.por
dc.description.sponsorshipFoundation for Science and Technology (FCT, Portugal) for PEst-OE/AGR/UI0690/2011, PEst-C/QUI/UI0686/2011, BD/78307/2011 (R. Guimarães), BPD/68344/2010 (R. Calhelha) and researcher contract of L. Barros.por
dc.identifier.citationGuimarães, Rafaela; Barros, Lillian; Calhelha, Ricardo C.; Carvalho, Ana Maria; Queiroz, Maria João R.P.; Ferreira, Isabel C.F.R. (2014). Bioactivity of different enriched phenolic extracts of wild fruits from Northeastern Portugal: a comparative study. Plant Foods for Human Nutrition. ISSN 0921-9668. 69:1, p. 37-42por
dc.identifier.doi10.1007/s11130-013-0394-5
dc.identifier.issn0921-9668
dc.identifier.urihttp://hdl.handle.net/10198/10150
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherSpringerpor
dc.relationBD/78307/2011
dc.relationStrategic Project - UI 690 - 2011-2012
dc.relationStrategic Project - UI 686 - 2011-2012
dc.subjectWild fruitspor
dc.subjectNortheastern Portugalpor
dc.subjectPhenolic compoundspor
dc.subjectAnthocyaninspor
dc.subjectAntioxidant activitypor
dc.subjectAntitumor effectspor
dc.titleBioactivity of different enriched phenolic extracts of wild fruits from Northeastern Portugal: a comparative studypor
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleStrategic Project - UI 690 - 2011-2012
oaire.awardTitleStrategic Project - UI 686 - 2011-2012
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FAGR%2FUI0690%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6820 - DCRRNI ID/PEst-C%2FQUI%2FUI0686%2F2011/PT
oaire.citation.endPage42por
oaire.citation.startPage37por
oaire.citation.titlePlant Foods for Human Nutritionpor
oaire.citation.volume69por
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6820 - DCRRNI ID
person.familyNameBarros
person.familyNameCalhelha
person.familyNameCarvalho
person.familyNameFerreira
person.givenNameLillian
person.givenNameRicardo C.
person.givenNameAna Maria
person.givenNameIsabel C.F.R.
person.identifier469085
person.identifierID G-7399-2011
person.identifier144781
person.identifier.ciencia-id9616-35CB-D001
person.identifier.ciencia-idF313-E3CE-554E
person.identifier.ciencia-idD31A-35AF-E2A9
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0001-5508-5935
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridJ-3600-2013
person.identifier.ridJ-2172-2014
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id20336503900
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspor
rcaap.typearticlepor
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