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Persistence of antioxidant, antimutagenic, and antigenotoxic properties of Polygonum maritimum L. extract after in vitro digestion supports its high potential as a functional food ingredient

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datacite.subject.fosCiências Agrárias::Biotecnologia Agrária e Alimentar
datacite.subject.fosEngenharia e Tecnologia::Engenharia Química
datacite.subject.sdg04:Educação de Qualidade
datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg09:Indústria, Inovação e Infraestruturas
dc.contributor.authorOliveira, Daniela
dc.contributor.authorHayrapetyan, Ruzanna
dc.contributor.authorDias, Maria Inês
dc.contributor.authorRodrigues, Maria João
dc.contributor.authorCorrea, Vanesa Gesser
dc.contributor.authorCarvalho, António Paulo
dc.contributor.authorCorre, Ludovic Le
dc.contributor.authorSéverin, Isabelle
dc.contributor.authorPeralta, Rosane Marina
dc.contributor.authorSantos, Miguel Machado
dc.contributor.authorCustódio, Luísa
dc.contributor.authorChagnon, Marie-Christine
dc.contributor.authorOliveira, Rui
dc.date.accessioned2026-06-02T17:54:58Z
dc.date.available2026-06-02T17:54:58Z
dc.date.issued2026
dc.description.abstractContinuous exposure to xenobiotic-contaminated food causes adverse effects that may lead to health complications, including cancer. Halophytes are rich in polyphenols that exhibit notable biological properties and may contribute to cancer prevention. However, digestion can modify the chemical structure of polyphenols, potentially reducing their biological properties. This study investigated the protective effects of a polyphenol-rich extract from the halophyte Polygonum maritimum L. (PME) against contaminants-induced toxicity and assessed the persistence of these properties following in vitro digestion. LC-DAD-ESI/MSn analysis revealed that the phenolic composition of PME decreased considerably after digestion. Nevertheless, the antioxidant activity of PME, measured as a decrease in reactive oxygen species levels in H2O2-challenged HepG2 cells, persisted post-digestion. The extract showed enhanced anti-inflammatory activity after digestion, as shown by the ability to reduce (NO)-N-center dot production in lipopolysaccharide-stimulated RAW 264.7 cells. The antigenotoxicity of PME against the contaminant benzo[a]pyrene (BaP) in Caco-2 and HepG2 cells remained significant following upper gastrointestinal tract digestion (DPME), whereas the antigenotoxicity against H2O2 only persisted in Caco-2 cells. After colonic fermentation (FPME), antigenotoxicity was observed against H2O2 in HepG2 cells. PME also displayed antimutagenicity towards BaP in Salmonella typhimurium TA98 and TA100 strains, which remained relevant in DPME, but was drastically reduced in FPME. Furthermore, Danio rerio fed with PME and BaP showed reduced negative effects in terms of size and lipid peroxidation. These results suggest that PME can protect against contaminants-induced toxicity along the gastrointestinal tract, maintaining bioactivity until colonic fermentation. Thus, PME can be a promising functional food ingredient for health improvement.eng
dc.description.sponsorshipD. Oliveira acknowledges the financial support provided by national funds through FCT – Portuguese Foundation for Science and Technology (PD/BD/135329/2017), under the PhD AgriChains (PD/00122/2012) and from the European Social Funds and the Regional Operational Programme Norte 2020. This study was also supported by the research units CITAB (UIDB/04033/2020); CBMA, Contrato-Programa UID/04050/2025 (funded by FCT I.P. https://doi.org/10.54499/UID/04050/2025); and CIIMAR (UIDB/04423/2020). This study had the support of FCT through the project LA/P/0069/2020 granted to the Associate Laboratory ARNET (https://doi.org/10.54499/LA/P/0069/2020). This study received Portuguese national funds from FCT through projects UIDB/04326/2020 (DOI:https://doi.org/10.54499/UIDB/04326/2020), UIDP/04326/2020 (DOI:https://doi.org/10.54499/UIDP/04326/2020), LA/P/0101/2020 (DOI:https://doi.org/10.54499/LA/P/0101/2020) and PTDC/BAA-AGR/1391/2020 (DOI https://doi.org/10.54499/PTDC/BAA-AGR/1391/2020) projects. L. Custódio acknowledges FCT for the Scientific Employment Stimulus (CEECIND/00425/2017, DOI: https://doi.org/10.54499/CEECIND/00425/2017/CP1391/CT0001), and Maria João Rodrigues for the FCT program contract (UIDP/04326/2020). The authors are also grateful to FCT for financial support through national funds FCT/MCTES (PIDDAC): UIDB/00690/2020 (DOI:https://doi.org/10.54499/UIDB/00690/2020) e UIDP/00690/2020 (DOI: https://doi.org/10.54499/UIDP/00690/2020); and SusTEC, LA/P/0007/2020 (DOI: https://doi.org/10.54499/LA/P/0007/2020). National funding by FCT, P.I., through the individual scientific employment program-contract for M.I.D. contract (CEECINST/00016/2018). This work was also supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, 304406/2019-8) and Fundação Araucária (160/2022).
dc.identifier.citationOliveira, Daniela; Hayrapetyan, Ruzanna; Dias, Maria Inês; Rodrigues, Maria João; Correa, Vanesa Gesser; Carvalho, António Paulo; Corre, Ludovic Le; Séverin, Isabelle; Peralta, Rosane Marina; Santos, Miguel Machado; Custódio, Luísa; Chagnon, Marie-Christine; Oliveira, Rui (2026). Persistence of antioxidant, antimutagenic, and antigenotoxic properties of Polygonum maritimum L. extract after in vitro digestion supports its high potential as a functional food ingredient. European Food Research and Technology. ISSN 1438-2377. 252:4, p. 1-20
dc.identifier.doi10.1007/s00217-026-05103-x
dc.identifier.issn1438-2377
dc.identifier.issn1438-2385
dc.identifier.urihttp://hdl.handle.net/10198/36830
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSpringer Nature
dc.relationValorisation of halophyte plants present in Portuguese territory through the investigation of their protective effects against food toxicants - Study of bioactivities of plant-based products to attenuate the effects of food toxicants
dc.relationCentre for the Research and Technology of Agro-Environmental and Biological Sciences
dc.relationInterdisciplinary Centre of Marine and Environmental Research
dc.relationAquatic Research Infrastructure Network
dc.relationAlgarve Centre for Marine Sciences
dc.relationAlgarve Centre for Marine Sciences
dc.relationCentre for Marine and Environmental Research
dc.relationExploring salt tolerant plants as sources of innovative food additives
dc.relationXtremebiotech - Unlocking the potential of extremophile marine halophytes as sources of innovative products with multiple biotechnological applications - CEECIND/00425/2017/CP1391/CT0001
dc.relationMountain Research Center - UIDP/00690/2020
dc.relationMountain Research Center - UIDB/00690/2020
dc.relationAssociate Laboratory for Sustainability and Tecnology in Mountain Regions - LA/P/0007/2020
dc.relationDeficiência de vitamina D2: estratégias integradas de eficiência de recursos para sua produção e incorporação em bebidas
dc.relationCentro de Biologia Molecular e Ambiental - UID/04050/2025
dc.relation.ispartofEuropean Food Research and Technology
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectAntioxidant
dc.subjectAntimutagenic
dc.subjectAntigenotoxic
dc.subjectPhenolics
dc.subjectSea knotgrass
dc.subjectSimulated digestion
dc.titlePersistence of antioxidant, antimutagenic, and antigenotoxic properties of Polygonum maritimum L. extract after in vitro digestion supports its high potential as a functional food ingredienteng
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