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Hydrophilic and lipophilic compounds in Arenaria montana L. and Chenopodium ambrosioides L. and bioactivity of their infusions and methanolic extracts

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dc.contributor.authorPereira, Eliana
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorBarros, Lillian
dc.contributor.authorCarvalho, Ana Maria
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2014-03-27T16:00:32Z
dc.date.available2014-03-27T16:00:32Z
dc.date.issued2013
dc.description.abstractSome plants traditionally used have medicinal properties with great potential for therapeutic applications in the treatment of some diseases since they are a natural source of bioactive compounds [1]. Arenaria Montana L. and Chenopodium ambrosioides L., commonly used in Portuguese folk medicine, are examples of those plants acting in the gastrointestinal tract, stomach, indigestion, respiratory system, flu, cold, vomiting, anthelmintics and in the healing of skin ulcers caused by Leishmania species; furthermore, they revealed anti-inflammatory and antitumor properties [2,3]. In this work, the chemical composition of the mentioned plants in hydrophilic (sugars and organic acids) and lipophilic (fatty acids and tocopherols) compounds was determined by chromatographic techniques. Furthermore, the bioactive properties (antioxidant and antitumour activities, and hepatotoxicity) of their infusions and methanolic extracts were evaluated and compared. Radical scavenging activity, reducing power and inhibition of lipid peroxidation in brain homogenates were used to evaluate antioxidant activity, while antitumor potential was screened in different human tumour cell lines: MCF-7 (breast carcinoma), NCI-H460 (lung carcinoma), HCT-15 (colon carcinoma), HeLa (cervical carcinoma) and HepG2 (hepatocellular carcinoma). Hepatotoxicity in nontumour liver cells was also accessed using a primary culture established by us (PLP2). C. ambrosioides was the most active regarding antioxidant activity (EC50 values 0.47-2.53 and 0.25-2.32 mg/mL for methanolic extract and infusion, respectively). A. montana infusion showed the highest antitumour activity in all the tested cell lines (GI50 values 58.67-231.08 μg/mL). This plant also gave the highest levels of saturated (43.16%) and monounsaturated (10.16%) fatty acids and sugars (10.15 g/100 g dw), particularly fructose (5.46 g/100 g dw). C. ambrosioides showed the highest content of α-linolenic acid (48.54%), tocopherols (202.34 mg/100 g dw), particularly α-tocopherol (199.37 mg/100 g dw) and organic acids (7.58 g/100 g dw), mainly oxalic acid (5.64 g/100 g dw). Overall, the studied plants proved to be good sources of natural bioactive compounds which may have industrial uses.por
dc.description.sponsorshipFundação para a Ciência e a Tecnologia (FCT, Portugal) for financial support to CIMO (strategic project PEst-OE/AGR/UI0690/2011). R.C. Calhelha and L. Barros also thank to FCT, POPHQREN and FSE for their grants (SFRH/BPD/ BPD/68344/2010 and SFRH/BPD/4609/2008, respectively).por
dc.identifier.citationPereira, Eliana; Calhelha, Ricardo C.; Barros, Lillian; Carvalho, Ana Maria; Ferreira, Isabel C.F.R. (2013). Hydrophilic and lipophilic compounds in Arenaria montana L. and Chenopodium ambrosioides L. and bioactivity of their infusions and methanolic extracts. In 1st International Symposium on Profiling. Almada. ISBN 978-989-98415-5-0por
dc.identifier.isbn978-989-98415-5-0
dc.identifier.urihttp://hdl.handle.net/10198/9391
dc.language.isoengpor
dc.peerreviewedyespor
dc.relationSFRH/BPD/4609/2008
dc.relationStrategic Project - UI 690 - 2011-2012
dc.titleHydrophilic and lipophilic compounds in Arenaria montana L. and Chenopodium ambrosioides L. and bioactivity of their infusions and methanolic extractspor
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleStrategic Project - UI 690 - 2011-2012
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FAGR%2FUI0690%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F68344%2F2010/PT
oaire.citation.conferencePlaceCaparica – Portugalpor
oaire.citation.titleInternational Symposium on Profilingpor
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamSFRH
person.familyNamePereira
person.familyNameCalhelha
person.familyNameBarros
person.familyNameCarvalho
person.familyNameFerreira
person.givenNameEliana
person.givenNameRicardo C.
person.givenNameLillian
person.givenNameAna Maria
person.givenNameIsabel C.F.R.
person.identifier469085
person.identifierID G-7399-2011
person.identifier144781
person.identifier.ciencia-idBE17-462D-9A75
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person.identifier.orcid0000-0003-2854-6745
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0001-5508-5935
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridQ-8017-2018
person.identifier.ridJ-2172-2014
person.identifier.ridJ-3600-2013
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id55938912300
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id20336503900
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspor
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